
#610: The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More
The Life-Extension Episode — Dr. Matt Kaeberlein on The Dog Aging Project, Rapamycin, Metformin, Spermidine, NAD+ Precursors, Urolithin A, Acarbose, and Much More | Brought to you by Levels real-time feedback on how diet impacts your health, Athletic Greens all-in-one nutritional supplement, and LMNT electrolyte supplement. More on all three below.Dr. Matt Kaeberlein (@mkaeberlein) is a professor of Laboratory Medicine and Pathology at the University of Washington School of Medicine, with adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on understanding biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life for people and companion animals.Dr. Kaeberlein is the founding director of the University of Washington Healthy Aging and Longevity Research Institute, the director of the NIH Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington, director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-director of the Dog Aging Project.Please enjoy!This episode is brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by LMNT! What is LMNT? It’s a delicious, sugar-free electrolyte drink mix. I’ve stocked up on boxes and boxes of this and usually use it 1–2 times per day. LMNT is formulated to help anyone with their electrolyte needs and perfectly suited to folks following a keto, low-carb, or Paleo diet. If you are on a low-carb diet or fasting, electrolytes play a key role in relieving hunger, cramps, headaches, tiredness, and dizziness.LMNT came up with a very special offer for you, my dear listeners. For a limited time, you can get a free LMNT Sample Pack with any purchase. This special offer is available here: DrinkLMNT.com/Tim.*This episode is also brought to you by Levels! I wrote about the health benefits of using continuous glucose monitors (CGMs) more than ten years ago in The 4-Hour Body. At the time, CGMs were primitive and hard to use. Levels has now made this technology, and the unique insights that come from it, easy and available to everyone. Levels is making glucose monitoring simple, helping you see how food affects your health through real-time feedback. I started tracking my glucose years ago to learn more about what I should and shouldn’t be eating (including quantities, time of day, etc.), based on objective data from my own, unique physiology. Keeping my blood sugar stable is critical to my daily and long-term health and performance goals. Furthermore, poor glucose control is associated with a number of chronic conditions like diabetes, Alzheimer’s disease, heart disease, and obesity. It’s important.If you’re interested in learning more about Levels and trying a CGM yourself, go to Levels.link/Tim.*[06:44] What is aging biology?[08:43] How Matt pivoted from mathematics to biology.[11:46] What is the Dog Aging Project?[13:42] Understanding healthspan through Matt’s frozen shoulder ordeal.[20:23] Rapamycin vs. sterile inflammation.[23:07] Current thoughts about how the immune system changes as we age.[29:11] Anti-aging uses for rapamycin (and potential risks/side effects).[42:20] Rapamycin and the Dog Aging Project.[45:30] Rapamycin vs. neurodegeneration.[48:21] What studies tell us about rapamycin’s potential to increase lifespan.[51:30] Rapamycin alternatives considered for the Dog Aging Project.[57:05] Urolithin A and spermidine.[59:45] 17 alpha estradiol.[1:01:47] Deprenyl.[1:03:54] NAD precursors.[1:05:52] What is Matt doing to increase his own lifespan/healthspan?[1:09:00] Is time-restricted feeding beneficial for dogs?[1:17:08] Currently, how well (or poorly) funded is longevity research?[1:22:02] Where additional funding in this field would be best leveraged.[1:35:19] Cutting through the hype and snake oil.[1:42:26] Metformin.[1:45:24] NAD infusion vs. natural NAD replenishment.[1:48:16] Sirtuins.[1:52:30] Resveratrol.[2:08:58] Is there a fix to liability in defensive medicine?[2:10:48] Finding better motivations for scientific pursuit.[2:15:48] Longevity scientists worth checking out.[2:17:39] Getting involved with the Dog Aging Project / parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
27 Juli 20222h 27min

#609: In Case You Missed It: June 2022 Recap of “The Tim Ferriss Show”
Welcome to another episode of The Tim Ferriss Show, where it is my job to deconstruct world-class performers to tease out the routines, habits, et cetera that you can apply to your own life. This is a special inbetweenisode, which serves as a recap of the episodes from last month. It features a short clip from each conversation in one place so you can easily jump around to get a feel for the episode and guest.Based on your feedback, this format has been tweaked and improved since the first recap episode. For instance, @hypersundays on Twitter suggested that the bios for each guest can slow the momentum, so we moved all the bios to the end. See it as a teaser. Something to whet your appetite. If you like what you hear, you can of course find the full episodes at tim.blog/podcast. Please enjoy! ***Timestamps:Jack Kornfield: 00:03:28Bill Burr: 00:09:43Edward Thorp: 00:14:53Jason Portnoy: 00:20:22Isabel Behncke: 00:26:36Sam Harris: 00:31:36***This episode is brought to you by 5-Bullet Friday, my very own email newsletter that every Friday features five bullet points highlighting cool things I’ve found that week, including apps, books, documentaries, gadgets, albums, articles, TV shows, new hacks or tricks, and—of course—all sorts of weird stuff I’ve dug up from around the world.It’s free, it’s always going to be free, and you can subscribe now at tim.blog/friday.***Full episode titles:Jack Kornfield — How to Overcome Apathy and Find Beautiful Purpose (#601)Legendary Comedian Bill Burr — Fear{less} with Tim Ferriss (#602)Master Investor Ed Thorp on How to Think for Yourself, Mental Models for the Second Half of Life, How to Be Inner-Directed, How Basic Numeracy Is a Superpower, and The Dangers of Investing Fads (#604)Jason Portnoy of PayPal, Palantir, and More — Porn Addiction, The Corrosiveness of Secrets, Healing Wounds, Escaping Shame Cycles, and Books to Change Your Life (#600)Primatologist Isabel Behncke on Play, Sexual Selection, and Lessons from Following Bonobos for 3,000 Kilometers in the Jungles of Congo (#598)New Insights from Sam Harris, Dr. Peter Attia, Ramit Sethi, and Elizabeth Gilbert (#599)***For show notes and past guests, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Balaji Srinivasan, Sarah Silverman, Dr. Andrew Huberman, Dr. Michio Kaku, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
24 Juli 202246min

#608: Signal Over Noise with Noah Feldman — The War in Ukraine (Recap and Predictions), The Machiavelli of Maryland, Best Books to Understand Geopolitics, The Battles for Free Speech on Social Media, Metaverse Challenges, and More
Tim Ferriss and Noah Feldman on The War in Ukraine (Recap and Predictions), The Machiavelli of Maryland, Best Books to Understand Geopolitics, The Battles for Free Speech on Social Media, Metaverse Challenges, and More | Brought to you by MANSCAPED premium grooming products, Athletic Greens all-in-one nutritional supplement, and Allform premium, modular furniture. More on all three below. I rarely cover current events on this podcast, but this is a new experiment.To avoid overwhelm, I do not track the news 24/7 with doom scrolling. Rather, I depend on conversations with my smartest friends to find the signal in the noise. The following conversation with Noah Feldman (@NoahRFeldman) is an example of such a conversation, very similar to what we would have offline, and I wanted to share it with you. I learned a ton and changed my thinking a lot, which I always do.Noah Feldman is a Harvard professor, ethical philosopher and advisor, public intellectual, religious scholar and historian, and author of 10 books, including his latest, The Broken Constitution: Lincoln, Slavery, and the Refounding of America. You can find my interview with him at tim.blog/noah.Noah is the founder of Ethical Compass, which helps clients like Facebook and eBay improve ethical decision-making by creating and implementing new governance solutions. Noah conceived and designed the Facebook Oversight Board and continues to advise Facebook on ethics and governance issues.Feldman is host of the Deep Background podcast, a policy and public affairs columnist for Bloomberg Opinion, and a former contributing writer for The New York Times. He served as senior constitutional advisor to the Coalition Provisional Authority in Iraq and subsequently advised members of the Iraqi Governing Council on the drafting of Iraq’s interim constitution.He earned his A.B. summa cum laude from Harvard, finishing first in his class. Selected as a Rhodes Scholar, he earned a DPhil from Oxford University, writing his dissertation on Aristotle’s Ethics. He received his JD from Yale Law School and clerked for Justice David Souter of the US Supreme Court.He is the author of 10 books, including Divided by God: America’s Church-State Problem — and What We Should Do About It; What We Owe Iraq: War and the Ethics of Nation Building; Cool War: The United States, China, and the Future of Global Competition; Scorpions: The Battles and Triumphs of FDR’s Great Supreme Court Justices; and The Three Lives of James Madison: Genius, Partisan, President.Please let me know what you think of this experimental format by sending me feedback on Twitter @tferriss. Do you love it? Do you hate it? Have suggestions for improvement? The usual long-form interviews with evergreen questions will still be the default and bread and butter of this podcast, but if you like this, I could see doing more of them, perhaps once a month or once every two months. It’s just an easy way to get caught up without drowning in news.Please enjoy!NOTE: This episode was recorded on June 22nd.*This episode is brought to you by MANSCAPED! MANSCAPED is bringing you the total package to ensure your package is the perfect package. No, I didn’t come up with that line… but I tested and loved their products, so I can vouch that I’m still intact and ready for my centerfold shoot. Was it scary? Yes. Was it worth it? Also yes. My girlfriend makes the effort, so I figured it was only fair. MANSCAPED is the most effective way to keep clean, pristine, and looking like a dream through the sweatiest summer months.The Perfect Package 4.0 is the ultimate grooming kit that includes everything you need for optimal below-the waist hygiene. Use their precision-engineered Lawn Mower 4.0—yes, “Lawn Mower”—electric trimmer to remove excess and avoid the dreaded swamp crotch. Feel confident in trimming hard-to-reach areas with MANSCAPED’s SkinSafe technology, which helps reduce the risk of nicks and snags. It’s time to take care of yourself; time for some basic landscaping. Get 20% off and free shipping with the code TIMTIM at Manscaped.com. *This episode is also brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by Allform! If you’ve been listening to the podcast for a while, you’ve probably heard me talk about Helix Sleep mattresses, which I’ve been using since 2017. They also launched a company called Allform that makes premium, customizable sofas and chairs shipped right to your door—at a fraction of the cost of traditional stores. You can pick your fabric (and they’re all spill, stain, and scratch resistant), the sofa color, the color of the legs, and the sofa size and shape to make sure it’s perfect for you and your home.Allform arrives in just 3–7 days, and you can assemble it yourself in a few minutes—no tools needed. To find your perfect sofa and receive 20% off all orders, check out Allform.com/Tim.*[08:40] Russia vs. Ukraine: why?[17:31] The first Web3 war?[25:24] Will punishing Russian oligarchs make Putin blink?[29:06] Did Putin miscalculate, or is he just playing a longer game?[38:19] Could this conflict affect the US dollar’s status as a reserve currency?[42:11] Exploring base/best/worst possible outcomes of the conflict.[47:56] Recommended reading.[58:15] Free speech in the age of social media.[1:14:07] What’s at stake as free speech is legally reevaluated?[1:23:18] Enforcement, decentralization, and free market considerations.[1:31:09] Where Noah sees the free speech conversation in three years.[1:35:50] Will the future be colored predominantly in AR or VR?[1:39:45] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
21 Juli 20221h 48min

#607: Luis von Ahn, Co-Founder and CEO of Duolingo — How to Be (Truly) Mission-Driven, Monetization Experiments, 10x Growth, Org Chart Iterations for Impacting Metrics, The Intricate Path to an IPO, Best Hiring Practices, Catching Exam Cheaters, The Allure of Toto Toilets, The Future of Duolingo, and How to Stand Out in Your Career
Brought to you by Athletic Greens all-in-one nutritional supplement, Helix Sleep premium mattresses, and LinkedIn Jobs recruitment platform with 800M+ users. Luis von Ahn (@LuisvonAhn) is an entrepreneur and consulting professor at Carnegie Mellon University, who is considered one of the pioneers of crowdsourcing. He is known for co-inventing CAPTCHAs, being a MacArthur fellow, and selling two companies to Google in his twenties.He is currently the co-founder and CEO of Duolingo, a language-learning platform created to bring free language education to the world. With more than 500 million users, it is now the most popular language-learning platform and the most downloaded education app in the world.Luis has been named one of the Brilliant 10 by Popular Science, one of the 50 Best Brains in Science by Discover, one of the Innovators Under 35 by MIT Technology Review, and one of the 100 Most Creative People in Business by Fast Company. Luis also won the 2018 Lemelson-MIT prize, the largest cash prize for invention in the U.S.This episode is brought to you by LinkedIn Jobs. Whether you are looking to hire now for a critical role or thinking about needs that you may have in the future, LinkedIn Jobs can help. LinkedIn screens candidates for the hard and soft skills you’re looking for and puts your job in front of candidates looking for job opportunities that match what you have to offer.Using LinkedIn’s active community of more than 800 million professionals worldwide, LinkedIn Jobs can help you find and hire the right person faster. When your business is ready to make that next hire, find the right person with LinkedIn Jobs. And now, you can post a job for free. Just visit LinkedIn.com/Tim.*This episode is also brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by Helix Sleep! Helix was selected as the #1 overall mattress of 2020 by GQ magazine, Wired, Apartment Therapy, and many others. With Helix, there’s a specific mattress to meet each and every body’s unique comfort needs. Just take their quiz—only two minutes to complete—that matches your body type and sleep preferences to the perfect mattress for you. They have a 10-year warranty, and you get to try it out for a hundred nights, risk-free. They’ll even pick it up from you if you don’t love it. And now, Helix is offering up to 200 dollars off all mattress orders plus two free pillows at HelixSleep.com/Tim.*[05:03] Why the Duolingo owl is green[06:47] The core cause behind Duolingo’s creation, and how Duolingo has evolved over the years[12:48] Duolingo’s monetization efforts that didn’t quite pan out[21:06] After initial reluctance, how was the Duolingo workforce convinced monetization needed to happen?[25:06] As machine-driven translation services get more sophisticated, will human beings still seek to learn other languages via Duolingo?[29:31] The most pursued/influential languages in the Duolingo system currently[39:14] The development of Duolingo’s org chart[45:40] Why Duolingo uses a daily metric[48:33] Book recommendations[50:26] Luis’ most worthwhile investments[52:20] New beliefs, behaviors, or habits[55:20] Recent life-changing purchases[1:02:39] What Luis’ updated 2022 billboard might say[1:06:14] What Luis means when he refers to Duolingo’s “mission,” and how the company’s long view affects decision making[1:12:34] How Duolingo hires good candidates for the long haul[1:18:50] Why and how Duolingo went public[1:25:42] The biggest challenges Luis faces as CEO of a public company[1:30:50] Duolingo is expanding to teach more than languages[1:36:18] The Duolingo English Test: proficiency testing from home accepted by 4,200 academic programs across the world[1:39:51] How Luis’ expertise at catching cheaters during his time as a professor at Carnegie Mellon makes Duolingo products more trustworthy as accredited sources[1:43:39] The brief conversation with Luis’ personal trainer that changed his routine breakfast — to a different routine breakfast[1:44:38] Advice to young, driven people entering the working world[1:48:07] How Luis has become better at saying “No.”[1:49:56] Luis’ request of the audience and parting thoughts*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
13 Juli 20222h

#606: Balaji S. Srinivasan — 5-10-Year Predictions, How to Start a New Country, Society-as-a-Service (SaaS), Bitcoin Maximalism, Memetic Warfare, How Prices Are Born, Moral Flippenings, The One Commandment, and The Power of Missionary over Mercenary
Brought to you by Eight Sleep’s Pod Pro Cover sleeping solution for dynamic cooling and heating, Athletic Greens all-in-one nutritional supplement, and Shopify global commerce platform providing tools to start, grow, market, and manage a retail business. Balaji S. Srinivasan (@balajis) is an angel investor and entrepreneur. Formerly the CTO of Coinbase and general partner at Andreessen Horowitz, he was also the co-founder of Earn.com (acquired by Coinbase), Counsyl (acquired by Myriad), Teleport (acquired by Topia), and Coin Center.He was named to the MIT Technology Review’s “Innovators Under 35,” won a Wall Street Journal Innovation Award, and holds a BS/MS/PhD in Electrical Engineering and an MS in Chemical Engineering, all from Stanford University. Balaji also teaches the occasional class at Stanford, including an online MOOC in 2013, which reached 250,000+ students worldwide.His new book is The Network State: How To Start a New Country. You can also read it for free at 1729.com.Please enjoy!This episode is brought to you by Shopify! Shopify is one of my favorite platforms and one of my favorite companies. Shopify is designed for anyone to sell anywhere, giving entrepreneurs the resources once reserved for big business. In no time flat, you can have a great looking online store that brings your ideas to life, and you can have the tools to manage your day-to-day and drive sales. No coding or design experience required.More than a store, Shopify grows with you, and they never stop innovating, providing more and more tools to make your business better and your life easier. Go to Shopify.com/Tim for a FREE 14-day trial and get full access to Shopify’s entire suite of features.*This episode is also brought to you by Eight Sleep! Eight Sleep’s Pod Pro Cover is the easiest and fastest way to sleep at the perfect temperature. It pairs dynamic cooling and heating with biometric tracking to offer the most advanced (and user-friendly) solution on the market. Simply add the Pod Pro Cover to your current mattress and start sleeping as cool as 55°F or as hot as 110°F. It also splits your bed in half, so your partner can choose a totally different temperature.And now, my dear listeners—that’s you—can get $250 off the Pod Pro Cover. Simply go to EightSleep.com/Tim or use code TIM at checkout. *This episode is also brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*[06:39] The current state of crypto and overall markets[14:41] Market depth and the Overton window[20:54] The challenges of identifying possible trends[24:25] Does transhumanism need rebranding?[27:13] Augmented reality glasses: the next big thing?[38:10] Rethinking Icarus from a transhumanist, pro-innovation perspective[59:20] DALL-E 2 as a compact programming language[1:02:03] Peter Turchin and cliodynamics[1:03:30] What is a network state?[1:17:49] Humans like to fight over borders—even when they're invisible[1:26:04] American anarchy[1:46:55] Bitcoin vs. gold as an inflation hedge[1:52:59] What needs to happen for Bitcoin to behave in the way Bitcoin holders would like it to behave?[2:24:29] Society as a service: how the establishment of a network state could succeed—without devolving into a cult[2:49:25] Chinese control; missionary over mercenary; innovation over top-down control[3:00:57] India's upward trends[3:05:57] Establishment disdain for tech interlopers (the feeling is mutual)[3:11:40] Parting thoughts*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
4 Juli 20223h 24min

#605: Hamilton Morris and Dr. Mark Plotkin — Exploring the History of Psychoactive Substances, Synthetic vs. Natural Options, Microdosing, 5-MeO-DMT, The “Drunken Monkey” Hypothesis, Timothy Leary’s Legacy, and More
Hamilton Morris and Dr. Mark Plotkin — Exploring the History of Psychoactive Substances, Synthetic vs. Natural Options, Microdosing, 5-MeO-DMT, The “Drunken Monkey” Hypothesis, Timothy Leary’s Legacy, and More | Brought to you by Athletic Greens all-in-one nutritional supplement and 5-Bullet Friday, my very own email newsletter. More on both below.Welcome to The Tim Ferriss Show, where it is usually my job to deconstruct world-class performers, to tease out their routines, habits, et cetera that you can apply to your own life. This time around, we have a very special edition featuring two of your favorite guests: Dr. Mark Plotkin and Hamilton Morris. Mark takes over my duties as host and interviews Hamilton for an episode of the Plants of the Gods podcast. You, my dear listeners, are hearing the audio before anyone else, so this is a Tim Ferriss Show exclusive. I’ve previously featured some of my favorite episodes from that show at tim.blog/plantsofthegods. These episodes cover a lot of fascinating ground.Who is Mark? Mark (@DocMarkPlotkin) is an ethnobotanist who serves as president of the Amazon Conservation Team, which has partnered with ~80 tribes to map and improve management and protection of ~100 million acres of ancestral rainforests. He is best known to the general public as the author of the book Tales of a Shaman’s Apprentice, one of the most popular books ever written about the rainforest. His most recent book is The Amazon: What Everyone Needs to Know. You can find my interview with Mark at tim.blog/markplotkin. And the guest today is Hamilton Morris. Hamilton (@HamiltonMorris) is a chemist, filmmaker, and science journalist. A graduate of The New School, he conducts chemistry research at Saint Joseph’s University. Hamilton is the writer and director of the documentary series Hamilton’s Pharmacopeia, in which he explores the chemistry and traditions surrounding psychoactive drugs. You can find my most recent interview with him at tim.blog/hamilton. This is a tightly packed 60-minute interview. Mark and Hamilton cover the history of different psychoactive substances, Timothy Leary’s legacy, the “drunken monkey” hypothesis, conservation, microdosing, the differences between 5-MeO-DMT and DMT, a disease that afflicts people who smoke enormous quantities of cannabis, causing them to vomit continuously and only find relief from their nausea by taking a hot shower (yes, really), the impact of the placebo effect, a synthetic vs. a natural product, the role of ritual, and much, much more. Please enjoy!*This episode is brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by 5-Bullet Friday, my very own email newsletter that every Friday features five bullet points highlighting cool things I’ve found that week, including apps, books, documentaries, gadgets, albums, articles, TV shows, new hacks or tricks, and—of course—all sorts of weird stuff I’ve dug up from around the world.It’s free, it’s always going to be free, and you can subscribe now at tim.blog/friday.*[06:22] The Sonoran desert toad's celebrity star is rising[08:18] The role of the chemist in preserving plants, animals, and fungi from which compounds are traditionally derived[11:18] Who is Howard Lotsof?[14:02] Microdosing[16:39] Ken Nelson and the celebrated Bufo Alvarius: The Psychedelic Toad of the Sonoran Desert pamphlet[20:11] God molecule vs. just plain old DMT[22:25] There are potential downsides to these compounds (even cannabis)[27:58] Undiscovered compounds[30:15] Lessons learned and questions pondered from Alexander Shulgin's thumb surgery[34:05] Synthetic vs. natural[37:21] The role of ritual[39:49] Combining traditions[42:27] Mark's account of Huautla in the early 2000s.[42:58] Downsides of psychedelic tourism[47:46] Effectiveness of fungi vs. frogs[49:52] Where do we go in search of new substances?[53:11] How far back do shamanic traditions go?[54:40] Poisons as medicines and vice versa[56:34] Salvia, and stoned vs. drunk apes[1:04:20] Nicolas Langlitz and the primatology of primatologists[1:06:03] Timothy Leary's legacy*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
1 Juli 20221h 11min

#604: Master Investor Ed Thorp on How to Think for Yourself, Mental Models for the Second Half of Life, How to Be Inner-Directed, How Basic Numeracy Is a Superpower, and The Dangers of Investing Fads
Brought to you by Wealthfront automated investing, Vuori comfortable and durable performance apparel, and Eight Sleep’s Pod Pro Cover sleeping solution for dynamic cooling and heating. Edward O. Thorp (@edwardothorp) is the author of the bestseller Beat the Dealer, which transformed the game of blackjack. His subsequent book, Beat the Market, coauthored with Sheen T. Kassouf, influenced securities markets around the globe. He is also the author of A Man for All Markets: From Las Vegas to Wall Street, How I Beat the Dealer and the Market.Edward was one of the world’s best blackjack players and investors, and his hedge funds were profitable every year for 29 years. He lives in Newport Beach, California.You can find our first conversation here.Please enjoy!This episode is brought to you by Wealthfront! Wealthfront pioneered the automated investing movement, sometimes referred to as ‘robo-advising,’ and they currently oversee $28 billion of assets for their clients. It takes about three minutes to sign up, and then Wealthfront will build you a globally diversified portfolio of ETFs based on your risk appetite and manage it for you at an incredibly low cost. Smart investing should not feel like a rollercoaster ride. Let the professionals do the work for you. Go to Wealthfront.com/Tim and open a Wealthfront account today, and you’ll get your first $5,000 managed for free, for life. Wealthfront will automate your investments for the long term. Get started today at Wealthfront.com/Tim.*This episode is also brought to you by Eight Sleep! Eight Sleep’s Pod Pro Cover is the easiest and fastest way to sleep at the perfect temperature. It pairs dynamic cooling and heating with biometric tracking to offer the most advanced (and user-friendly) solution on the market. Simply add the Pod Pro Cover to your current mattress and start sleeping as cool as 55°F or as hot as 110°F. It also splits your bed in half, so your partner can choose a totally different temperature.And now, my dear listeners—that’s you—can get $250 off the Pod Pro Cover. Simply go to EightSleep.com/Tim or use code TIM at checkout. *This episode is also brought to you by Vuori clothing! Vuori is a new and fresh perspective on performance apparel, perfect if you are sick and tired of traditional, old workout gear. Everything is designed for maximum comfort and versatility so that you look and feel as good in everyday life as you do working out.Get yourself some of the most comfortable and versatile clothing on the planet at VuoriClothing.com/Tim. Not only will you receive 20% off your first purchase, but you’ll also enjoy free shipping on any US orders over $75 and free returns.*[06:39] The value of long-term thinking and the price of short-term thinking[07:57] What is a common stock warrant?[09:52] Why are people generally poor at taking longer term (or alternative) perspectives?[11:08] Conversing about numeracy and common misunderstandings[15:00] How to become more numeracy literate[20:18] It’s Raining Man[22:31] The Rule of 72[26:14] Making the best financial decisions with unknown variables[35:57] How to have fun learning about probability and statistics[37:47] How to get an edge in hedge fund investing (with book recommendations)[46:23] Ed’s methods for losing (or maintaining) weight and looking 60 in spite of being almost 90 years old[53:38] Favorite beer[55:03] Music as stress reduction[56:02] Avoiding unnecessary risks[1:04:12] The age-guessing experiment[1:06:17] Other-directed vs. inner-directed and takeaways from The Lonely Crowd by David Riesman[1:14:35] How an 89-year-old maintains hair growth[1:17:20] Using scrap time[1:19:45] A big change in Ed’s later life that increased its quality[1:22:16] New reflections, future hopes, and parting thoughts*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
28 Juni 20221h 33min

#603: In Case You Missed It: May 2022 Recap of "The Tim Ferriss Show"
Welcome to another episode of The Tim Ferriss Show, where it is my job to deconstruct world-class performers to tease out the routines, habits, et cetera that you can apply to your own life. This is a special inbetweenisode, which serves as a recap of the episodes from last month. It features a short clip from each conversation in one place so you can easily jump around to get a feel for the episode and guest.Based on your feedback, this format has been tweaked and improved since the first recap episode. For instance, @hypersundays on Twitter suggested that the bios for each guest can slow the momentum, so we moved all the bios to the end. See it as a teaser. Something to whet your appetite. If you like what you hear, you can of course find the full episodes at tim.blog/podcast. Please enjoy! ***Timestamps:EDWARD O. THORP: 00:01:42MORGAN FALLON: 00:10:14RICHARD WISEMAN: 00:19:11DENNIS MCKENNA: 00:31:16CAL NEWPORT: 00:39:28***Full episode titles: Edward O. Thorp, A Man for All Markets — Beating Blackjack and Roulette, Beating the Stock Market, Spotting Bernie Madoff Early, and Knowing When Enough Is Enough (#596)Morgan Fallon — 10 Years on the Road with Anthony Bourdain, 9 Emmy Nominations, Lessons from Michael Mann, Adventures with Steven Rinella, High Standards, Wisdom from West Virginia, and More (#597)Richard Wiseman on Lessons from Dale Carnegie, How to Keep a Luck Diary, Mentalism, The Psychology of the Paranormal, Mass Participation Experiments, NLP, Remote Viewing, and Attempting the Impossible (#593)Dennis McKenna — An Ethnopharmacologist on Hallucinogens, Sex-Crazed Cicadas, The Mushrooms of Language, BioGnosis, and Illuminating Obscure Corners (#592)Cal Newport and Tim Ferriss Revisit “The 4-Hour Workweek” (Plus: The Allure and The Void of Remote Work, Unsustainable Behaviors, Burning Out, The Cult of Productivity, and More) (#594)***For show notes and past guests, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Balaji Srinivasan, Sarah Silverman, Dr. Andrew Huberman, Dr. Michio Kaku, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
24 Juni 202252min