298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

Support Mindscape on Patreon.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Avsnitt(412)

288 | Max Richter on the Meaning of Classical Music Today

288 | Max Richter on the Meaning of Classical Music Today

It wasn't that long ago, historically speaking, that you might put on your tuxedo or floor-length evening gown to go out and hear a live opera or symphony. But today's world is faster, more technologi...

9 Sep 20241h 6min

AMA | September 2024

AMA | September 2024

Welcome to the September 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by P...

2 Sep 20243h 50min

287 | Jean-Paul Faguet on Institutions and the Legacy of History

287 | Jean-Paul Faguet on Institutions and the Legacy of History

One common feature of complex systems is sensitive dependence on initial conditions: a small change in how systems begin evolving can lead to large differences in their later behavior. In the social s...

26 Aug 20241h 32min

286 | Blaise Agüera y Arcas on the Emergence of Replication and Computation

286 | Blaise Agüera y Arcas on the Emergence of Replication and Computation

Understanding how life began on Earth involves questions of chemistry, geology, planetary science, physics, and more. But the question of how random processes lead to organized, self-replicating, info...

19 Aug 20241h 20min

285 | Nate Silver on Prediction, Risk, and Rationality

285 | Nate Silver on Prediction, Risk, and Rationality

Being rational necessarily involves engagement with probability. Given two possible courses of action, it can be rational to prefer the one that could possibly result in a worse outcome, if there's al...

12 Aug 20241h 11min

AMA | August 2024

AMA | August 2024

Welcome to the August 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patr...

5 Aug 20243h 37min

284 | Doris Tsao on How the Brain Turns Vision Into the World

284 | Doris Tsao on How the Brain Turns Vision Into the World

The human brain does a pretty amazing job of taking in a huge amount of data from multiple sensory modalities -- vision, hearing, smell, etc. -- and constructing a coherent picture of the world, const...

29 Juli 20241h 2min

283 | Daron Acemoglu on Technology, Inequality, and Power

283 | Daron Acemoglu on Technology, Inequality, and Power

Change is scary. But sometimes it can all work out for the best. There's no guarantee of that, however, even when the change in question involves the introduction of a powerful new technology. Today's...

22 Juli 20241h 17min

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