298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

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262 | Eric Schwitzgebel on the Weirdness of the World

262 | Eric Schwitzgebel on the Weirdness of the World

Scientists and philosophers sometimes advocate pretty outrageous-sounding ideas about the fundamental nature of reality. (Arguably I have been guilty of this.) It shouldn't be surprising that reality,...

15 Jan 20241h 20min

261 | Sanjana Curtis on the Origins of the Elements

261 | Sanjana Curtis on the Origins of the Elements

In mid-20th-century cosmology, there was a debate over the origin of the chemical elements. Some thought that they could be produced in the Big Bang, while others argued that they were made inside sta...

8 Jan 20241h 7min

260 | Ricard Solé on the Space of Cognitions

260 | Ricard Solé on the Space of Cognitions

Octopuses, artificial intelligence, and advanced alien civilizations: for many reasons, it's interesting to contemplate ways of thinking other than whatever it is we humans do. How should we think abo...

1 Jan 20241h 10min

Holiday Message: Reflections on Immortality

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The final Mindscape podcast of each year is devoted to a short, reflective Holiday Message. This year the theme is Immortality: whether it's an attractive idea, and whether the laws of physics and cos...

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259 | Adam Frank on What Aliens Might Be Like

259 | Adam Frank on What Aliens Might Be Like

It wasn't that long ago that topics like the nature of consciousness, or the foundations of quantum mechanics, or prospects for extraterrestrial life were considered fringey and disreputable by much o...

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AMA | December 2023

AMA | December 2023

Welcome to the December 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Pa...

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258 | Solo: AI Thinks Different

258 | Solo: AI Thinks Different

The Artificial Intelligence landscape is changing with remarkable speed these days, and the capability of Large Language Models in particular has led to speculation (and hope, and fear) that we could ...

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257 | Derek Guy on the Theory and Practice of Dressing Well

257 | Derek Guy on the Theory and Practice of Dressing Well

Putting on clothes is one of the most universal human experiences. Inevitably, this involves choices; maybe you just grab the cheapest and most convenient clothing available, or maybe you want to fit ...

20 Nov 20231h 20min

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