298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

Support Mindscape on Patreon.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

Avsnitt(416)

193 | Daniels on Everything, Everywhere, All at Once

193 | Daniels on Everything, Everywhere, All at Once

Every time we make an important decision, it's hard not to wonder how things would have turned out had we chosen differently. The set of all those hypothetical lives is a kind of "multiverse" — not on...

18 Apr 20221h 8min

AMA | April 2022

AMA | April 2022

Welcome to the April 2022 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of quest...

14 Apr 20223h 27min

192 | Nicole Yunger Halpern on Quantum Steampunk Thermodynamics

192 | Nicole Yunger Halpern on Quantum Steampunk Thermodynamics

Randomness and probability are central to modern physics. In statistical mechanics this is because we don't know everything about the distribution of atoms and molecules in a fluid, so we consider a p...

11 Apr 20221h 17min

191 | Jane McGonigal on How to Imagine the Future

191 | Jane McGonigal on How to Imagine the Future

The future grows out of the present, but it manages to consistently surprise us. How can we get better at anticipating and preparing for what the future can be like? Jane McGonigal started out as a ga...

4 Apr 20221h 21min

190 | Lea Goentoro on Regrowing Limbs

190 | Lea Goentoro on Regrowing Limbs

Biological organisms are pretty good at healing themselves, but their abilities fall short in crucial ways. Planaria can be cut into pieces, and each piece will regrow into an entire organism; but for...

28 Mars 20221h 3min

189 | Brian Klaas on Power and the Temptation of Corruption

189 | Brian Klaas on Power and the Temptation of Corruption

All societies grant more power to some citizens, and there is always a temptation to use that power for the benefit of themselves rather than for the greater good. Power corrupts, we are told — but to...

21 Mars 20221h 22min

AMA | March 2022

AMA | March 2022

Welcome to the March 2022 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of quest...

17 Mars 20223h 18min

188 | Arik Kershenbaum on What Aliens Will Be Like

188 | Arik Kershenbaum on What Aliens Will Be Like

If extraterrestrial life is out there — not just microbial slime, but big, complex, macroscopic organisms — what will they be like? Movies have trained us to think that they won't be that different at...

14 Mars 20221h 21min

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