298 | Jeff Lichtman on the Wiring Diagram of the Brain

298 | Jeff Lichtman on the Wiring Diagram of the Brain

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome: the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/

Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences.

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Avsnitt(427)

80 | Jenann Ismael on Connecting Physics to the World of Experience

80 | Jenann Ismael on Connecting Physics to the World of Experience

Physics is simple; people are complicated. But even people are ultimately physical systems, made of particles and forces that follow the rules of the Core Theory. How do we bridge the gap from one kin...

20 Jan 20201h 26min

79 | Sara Imari Walker on Information and the Origin of Life

79 | Sara Imari Walker on Information and the Origin of Life

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13 Jan 20201h 23min

78 | Daniel Dennett on Minds, Patterns, and the Scientific Image

78 | Daniel Dennett on Minds, Patterns, and the Scientific Image

Wilfrid Sellars described the task of philosophy as explaining how things, in the broadest sense of term, hang together, in the broadest sense of the term. (Substitute "exploring" for "explaining" and...

6 Jan 20202h 1min

Holiday Message 2019: On Publishing Books

Holiday Message 2019: On Publishing Books

Welcome to the second annual Mindscape Holiday Message! No substantive content or deep ideas, just me talking a bit about the state of the podcast and what's on my mind. Since the big event for me in ...

22 Dec 20191h 6min

77 | Azra Raza on The Way We Should Fight Cancer

77 | Azra Raza on The Way We Should Fight Cancer

In the United States, more than one in five deaths is caused by cancer. The medical community has put enormous resources into fighting this disease, yet its causes and best treatments continue to be a...

16 Dec 20191h 22min

76 | Ned Hall on Possible Worlds and the Laws of Nature

76 | Ned Hall on Possible Worlds and the Laws of Nature

It's too easy to take laws of nature for granted. Sure, gravity is pulling us toward Earth today; but how do we know it won't be pushing us away tomorrow? We extrapolate from past experience to future...

9 Dec 20191h 25min

75 | Max Tegmark on Reality, Simulation, and the Multiverse

75 | Max Tegmark on Reality, Simulation, and the Multiverse

We've talked a lot recently about the Many Worlds of quantum mechanics. That's one kind of multiverse that physicists often contemplate. There is also the cosmological multiverse, which we talked abou...

2 Dec 20191h 11min

74 | Stephen Greenblatt on Stories, History, and Cultural Poetics

74 | Stephen Greenblatt on Stories, History, and Cultural Poetics

An infinite number of things happen; we bring structure and meaning to the world by making art and telling stories about it. Every work of literature created by human beings comes out of an historical...

25 Nov 20191h 6min

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