Real-World Impact: How Targeted Therapy is Changing Cholangiocarcinoma Treatment
SciPod18 Dec 2024

Real-World Impact: How Targeted Therapy is Changing Cholangiocarcinoma Treatment

Cholangiocarcinoma is an aggressive cancer that begins in the bile ducts. While the cancer is relatively rare, affecting approximately 8,000 people in the United States each year, unfortunately, it is often undiagnosed until an advanced stage. This late diagnosis makes cholangiocarcinoma very challenging to treat, and less than 10% of patients survive for five years after diagnosis. Traditional anti-cancer treatments, such as chemotherapy, have only limited effectiveness in cholangiocarcinoma, and can cause serious side effects. Recently developed immunotherapy and targeted therapies have provided promising options for this difficult-to-treat disease. Dr. Kim Saverno of the Incyte Corporation, a biopharmaceutical company headquartered in the U.S., and the study’s co-authors, have been studying the real-world use of an FDA-approved targeted drug for cholangiocarcinoma called pemigatinib. Pemigatinib was approved by the FDA in 2020. It can be specifically used for cholangiocarcinoma patients who have genetic changes in a protein known as fibroblast growth factor receptor 2, or FGFR2 for short. Their study, to the best of our knowledge, is the first to examine pemigatinib's use in real-world settings, and reveals information about treatment patterns, FGFR2 testing patterns, and effectiveness of pemigatinib for cholangiocarcinoma when used in everyday practice.

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(639)

Reading Ancient Pollen to Reconstruct a Lost World in Java

Reading Ancient Pollen to Reconstruct a Lost World in Java

More than a million years ago, the island of Java looked very different from the busy, densely populated place we know today. Vast mangrove forests spread along muddy coastlines. Freshwater swamps str...

24 Juni 12min

Balancing Safety: Rethinking Prevention and Mitigation in a Complex World

Balancing Safety: Rethinking Prevention and Mitigation in a Complex World

In the world of nuclear energy, safety is not a single switch that can be turned on or off. It is a layered, evolving philosophy shaped by decades of engineering, research, and experience. At the hear...

18 Juni 9min

Seeing the Invisible: How Polarized Light Contributes to Our Understanding and Detection of Cancer

Seeing the Invisible: How Polarized Light Contributes to Our Understanding and Detection of Cancer

Light is something we encounter every day, so familiar that it rarely inspires a second thought. Yet beneath its apparent simplicity lies a remarkable complexity. Light can carry information in its br...

11 Juni 15min

When Standing Up Knocks You Down: Why Postural Hypotension Goes Unnoticed

When Standing Up Knocks You Down: Why Postural Hypotension Goes Unnoticed

Imagine standing up from a chair and feeling a sudden wave of dizziness, as though the floor beneath you has shifted. For many older adults, this is more than just an occasional inconvenience, it’s a ...

10 Juni 10min

The Secret Life of the Margay in Peru’s Rainforest

The Secret Life of the Margay in Peru’s Rainforest

Deep in the Amazon rainforest of southeastern Peru, one of the world's most elusive wild cats slips silently through the trees. Smaller than a jaguar and far less famous than a tiger, the margay is a ...

9 Juni 11min

On the Front Lines of a Pandemic: Sierra Leone’s Field Epidemiology Training Program Success Story

On the Front Lines of a Pandemic: Sierra Leone’s Field Epidemiology Training Program Success Story

In early 2020, as headlines around the world warned of a fast-spreading new virus, Sierra Leone watched with a mixture of concern and determination. The country had not forgotten the devastating Ebola...

3 Juni 14min

Quand la chaleur rencontre la route: comment la hausse des températures modifie la sécurité routière en milieu urbain

Quand la chaleur rencontre la route: comment la hausse des températures modifie la sécurité routière en milieu urbain

Lors d’une journée d’été étouffante, la plupart d’entre nous remarquent les effets évidents de la chaleur. Nous nous sentons plus lents, plus irritables et impatients d’échapper au soleil. Ce qui est ...

1 Juni 10min

From Silence to Survival: 150 Years of Laryngectomy and the Future of Voice

From Silence to Survival: 150 Years of Laryngectomy and the Future of Voice

In the late nineteenth century, medicine stood at a threshold between desperation and discovery. Cancer of the larynx, the structure that gives us voice and guards our airway, was almost always fatal....

31 Maj 8min

Populärt inom Vetenskap

p3-dystopia
dumma-manniskor
allt-du-velat-veta
kapitalet-en-podd-om-ekonomi
medicinvetarna
doden-hjarnan-kemisten
svd-nyhetsartiklar
rss-kriminologerna
bildningspodden
ufo-sverige
sexet
dumforklarat
rss-spraket
rss-vetenskapsradion
rss-arkeologi-historia-podden-som-graver-i-vart-kulturlandskap
4health-med-anna-sparre
rss-ufobortom-rimligt-tvivel
vetenskapsradion
rss-tidslinjen-podcast
hacka-livet