Episode 171: 171.  Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

Episode 171: 171. Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

SGLT2 inhibitors and GLP1 agonists administered without metformin compared to other glucose‐lowering drugs in patients with type 2 diabetes mellitus to prevent cardiovascular events: A systematic review - Escobar - 2021 - Diabetic Medicine - Wiley Online Library

Yes these fancy new drugs work with and without metformin but that does not mean these drugs should be first line!!


Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA | JAMA Network


Yep even 200,000IU of vit D does nothing except raise your vit d level.

Diet and acne: review of the evidence from 2009 to 2020 - Dall’Oglio - - International Journal of Dermatology - Wiley Online Library


What you eat does mess with your acne, or at least says this large observational trial.


Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials | The BMJ

The muscle aches with statins is a common event that it occurs as frequently with the active drug as it does with placebo

Avsnitt(386)

Episode 344: 343. Arm position and blood pressure readings: The ARMS crossover randomized clinical trial

Episode 344: 343. Arm position and blood pressure readings: The ARMS crossover randomized clinical trial

Liu H et al. Arm position and blood pressure readings: The ARMS crossover randomized clinical trial. JAMA Intern Med 2024 Oct 7; [e-pub]. (https://doi.org/10.1001/jamainternmed.2024.5213)   study repl...

8 Nov 20245min

Episode 342: 341.  Methods Monday! What is the problem with stopping a trial EARLY?

Episode 342: 341. Methods Monday! What is the problem with stopping a trial EARLY?

Stopping Trials Early for Benefit: Insights From Recent Pivotal Trials in Chronic Kidney Disease - ScienceDirect   There are 4 major reasons why trials might be stopped early: 1) unequivocal benefit; ...

4 Nov 20248min

Episode 341: 340. ACOI -- Vitamin D and Calcium Made Easy

Episode 341: 340. ACOI -- Vitamin D and Calcium Made Easy

You get the CME knowledge without the CME payment!

30 Okt 202438min

Episode 340: 339. Reaction Risk to Direct Penicillin Challenges

Episode 340: 339. Reaction Risk to Direct Penicillin Challenges

10% of hospitalized patients have penicillin allergy listed in their records, fewer than 1% of patients have true allergies. Use of more-expensive and broader-spectrum antibiotics is associated with l...

29 Okt 20245min

Episode 339: 338. Hypertension Treatment With New Triple Single Pill Combination

Episode 339: 338. Hypertension Treatment With New Triple Single Pill Combination

Efficacy and Safety of a Novel Low-Dose Triple Single-Pill Combination Compared With Placebo for Initial Treatment of HypertensionJ Am Coll Cardiol 2024 Aug 30;[EPub Ahead of Print], A Rodgers, A Sala...

25 Okt 20249min

Episode 338: 337. What is the ideal Vitamin D Level to target?

Episode 338: 337. What is the ideal Vitamin D Level to target?

In 2011, the Endocrine Society published a guideline on “Evaluation, Treatment, and Prevention of Vitamin D Deficiency”   Now, the Society has issued an updated guideline, Demay MB et al. Vitamin D fo...

22 Okt 20245min

Episode 337: 336. 24 Hours After a Stroke for EVT- 2 yr Follow-Up

Episode 337: 336. 24 Hours After a Stroke for EVT- 2 yr Follow-Up

Huijberts I et al. Collateral-based selection for endovascular treatment of acute ischaemic stroke in the late window (MR CLEAN-LATE): 2-year follow-up of a phase 3, multicentre, open-label, randomise...

18 Okt 20246min

Episode 336: 335. Do GLP-1 Cause Residual Gastric Contents

Episode 336: 335. Do GLP-1 Cause Residual Gastric Contents

Because glucagon-like peptide-1 (GLP-1) receptor agonists can slow gastric emptying, they might confer risk for residual gastric contents — and possibly aspiration!!!! Should we stop the glp-1 Should ...

10 Okt 20245min

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