Episode 271: 270. Aprocitentan, How Well Does it Work for Resistant Hypertension?
730 Patients were randomized to receive daily oral aprocitentan or placebo, plus a fixed-dose combination of amlodipine, valsartan, and hydrochlorothiazide.After 4 weeks, mean change in office systoli...
16 Apr 20246min
Episode 270: 269. What is the Harm in Aspirin?
The trial was terminated after 1015 patients with atrial cardiopathy had been randomized to receive either apixaban or aspirin for a mean follow-up of 1.8 years, recurrent stroke rates were identical...
15 Apr 20244min
Episode 268: 268. New Guidelines For Total Hip and Knee Joint Replacement
TJA should not be delayed for trials of physical therapy, anti-inflammatory drug use, bracing, intra-articular steroid injections, or hyaluronic acid injections. For patients with obesity, proceed to...
12 Apr 20247min
Episode 269: 267. Beta Blockers DON'T Help Post-MI
randomized trial comparingbeta-blocker therapy (metoprolol or bisoprolol) with no beta-blocker in 5020 patients who had a normal left-ventricular ejection fraction (LVEF) after AMI median follow-up of...
11 Apr 20246min
Episode 267: 266. How Many Years Of Smoking Cessation Do You Need?
During a mean 11 years of follow-up, current smokers' risks for cardiovascular-, cancer-, and respiratory-related deaths were 2, 3, and 13 times higher, respectively, than never smokers' risks. Former...
10 Apr 20245min
Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL
The primary cardiovascular end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke in a time-to-first-event analysis.Improvement innonfatal st...
9 Apr 20248min
Episode 265: 264. Does a Lidocaine Patch Work for Neck Pain?
Bottom line(ZTLido 1.8%) is a brand name lidocaine patch currently approced for postherpetic neuralgia and will stay that why for now as it did not beat placebo for the treatment of patients with chro...
5 Apr 20245min
Episode 264: 263. Rates of Atrial Fibrillation 12 months After Onset of Hospitalized Transient AF
patients who have new-onset transient AF detected during a hospitalization for noncardiac surgery or medical illness and are discharged in sinus rhythm, approximately 1 in 3 have AF detected in the ye...
4 Apr 20247min
