Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes

Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes


Question What is the strength of association between surrogate markers used as primary end points in clinical trials to support Food and Drug Administration (FDA) approval of drugs treating nononcologic chronic diseases and clinical outcomes?

often surrogate markers are used as primary end points in clinical trials to support FDA approval of drugs

I get it

Surrogate markers offer the advantage of reducing the duration, size, and total cost of trials

n 2018, the Food and Drug Administration (FDA) publicly released an Adult Surrogate Endpoint Table of more than 100 surrogate markers that may be used as primary end points in clinical trials that form the basis of traditional or accelerated approval of new drugs or biologics.

The authors evaluated Thirty-seven surrogate markers listed in FDA’s table of markers that can be used as primary end points in clinical trials across 32 unique nononcologic chronic diseases.


Most surrogate markers used as primary end points in clinical trials to support FDA approval of drugs treating nononcologic chronic diseases lacked high-strength evidence of associations with clinical outcomes from published meta-analyses.


https://jamanetwork.com/journals/jama/article-abstract/2817850

Avsnitt(386)

75. Sun Protection, Prostate and Atrial Fib Screening?

75. Sun Protection, Prostate and Atrial Fib Screening?

Another episode with lots of articles- What is the UVB protection on SPF. Atrial fib screening, should we do it? What IUD makes you not gain weight? One article on Fake news on babies sleeping and a n...

12 Aug 201826min

74. Lots of articles and 2 that will change guidelines

74. Lots of articles and 2 that will change guidelines

Joe Namath is famous for guaranteeing victory in Super Bowl III. Mark your calendars for 7/24/2018 where I guarantee that two of the articles in this episode will change guidelines. This episode is fu...

25 Juli 201826min

73. Compressing evidence on bones, colon cancer, pregnancy loss and listen questions

73. Compressing evidence on bones, colon cancer, pregnancy loss and listen questions

So much goodness in one podcast it would be a shame to list it all here. So stop reading and just hit play already.

12 Juli 201835min

72. Swelling Over ACEI and Seizing On 3 Articles

72. Swelling Over ACEI and Seizing On 3 Articles

In this episode we cover what I think it game time ready about our beloved ACEI and then Joe and I talk about 3 articles that you need to know including the new seizure medication just approved by the...

27 Juni 201828min

71. Breaking Bones and A1C Levels Should Put You into A.fib

71. Breaking Bones and A1C Levels Should Put You into A.fib

In this 'royal' episode I cover new papers on diabetes type 2, osteoporosis and A.fib. As always you can reach me on twitter @andrewbuelt or email me andrewbuelt@gmail.com

19 Maj 201823min

70. More Articles and a Vegan Study To Make a T-Rex Eat a Salad

70. More Articles and a Vegan Study To Make a T-Rex Eat a Salad

So many article so little time AND in this episode Joe stops in to talk about a study that would make ever T-Rex eat a salad

10 Maj 201819min

 69. NBA playoffs w/ Coronary Calcium, VEST, and Dialysis O, MY

69. NBA playoffs w/ Coronary Calcium, VEST, and Dialysis O, MY

It is NBA playoff season and this podcast starts with a fast break into coronary calcium testing, Slams into John Mandrola review https://www.medscape.com/viewarticle/893756 with transition into CKD +...

28 Apr 201820min

68. Anti-biotics Still Have Harm and 2 Guidelines to Know About

68. Anti-biotics Still Have Harm and 2 Guidelines to Know About

If you were wondering antibiotics, yes, still have harm and should still be used with caution. Medical students are in a panic since there is a new answer to the c. diff board question and FINALLY a g...

14 Apr 201818min

Populärt inom Hälsa

somna-med-henrik
rss-bara-en-till-om-missbruk-medberoende-2
rss-jossan-nina
inga-beiga-morsor
alska-oss
not-fanny-anymore
johannes-hansen-podcast
rss-vuxna-pa-latsas
angestpodden
rss-viktmedicinpodden
sa-in-i-sjalen
sova-med-dan-horning
sexnoveller-deluxe
rss-psykoterapipodden
brottarbroder
rss-aldrig-lagom
rss-basta-livet
rss-sjalsligt-avkladd
giggles-med-wiggles
rss-the-house-podcast-3