Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Avsnitt(387)

Episode 345: 244. CORRECTED ACOI question and answer

Episode 345: 244. CORRECTED ACOI question and answer

The full podcast -- not sure why the last one cut off early. Question and answer from ACOI

15 Nov 202416min

Episode 344: 343. Arm position and blood pressure readings: The ARMS crossover randomized clinical trial

Episode 344: 343. Arm position and blood pressure readings: The ARMS crossover randomized clinical trial

Liu H et al. Arm position and blood pressure readings: The ARMS crossover randomized clinical trial. JAMA Intern Med 2024 Oct 7; [e-pub]. (https://doi.org/10.1001/jamainternmed.2024.5213)   study repl...

8 Nov 20245min

Episode 342: 341.  Methods Monday! What is the problem with stopping a trial EARLY?

Episode 342: 341. Methods Monday! What is the problem with stopping a trial EARLY?

Stopping Trials Early for Benefit: Insights From Recent Pivotal Trials in Chronic Kidney Disease - ScienceDirect   There are 4 major reasons why trials might be stopped early: 1) unequivocal benefit; ...

4 Nov 20248min

Episode 341: 340. ACOI -- Vitamin D and Calcium Made Easy

Episode 341: 340. ACOI -- Vitamin D and Calcium Made Easy

You get the CME knowledge without the CME payment!

30 Okt 202438min

Episode 340: 339. Reaction Risk to Direct Penicillin Challenges

Episode 340: 339. Reaction Risk to Direct Penicillin Challenges

10% of hospitalized patients have penicillin allergy listed in their records, fewer than 1% of patients have true allergies. Use of more-expensive and broader-spectrum antibiotics is associated with l...

29 Okt 20245min

Episode 339: 338. Hypertension Treatment With New Triple Single Pill Combination

Episode 339: 338. Hypertension Treatment With New Triple Single Pill Combination

Efficacy and Safety of a Novel Low-Dose Triple Single-Pill Combination Compared With Placebo for Initial Treatment of HypertensionJ Am Coll Cardiol 2024 Aug 30;[EPub Ahead of Print], A Rodgers, A Sala...

25 Okt 20249min

Episode 338: 337. What is the ideal Vitamin D Level to target?

Episode 338: 337. What is the ideal Vitamin D Level to target?

In 2011, the Endocrine Society published a guideline on “Evaluation, Treatment, and Prevention of Vitamin D Deficiency”   Now, the Society has issued an updated guideline, Demay MB et al. Vitamin D fo...

22 Okt 20245min

Episode 337: 336. 24 Hours After a Stroke for EVT- 2 yr Follow-Up

Episode 337: 336. 24 Hours After a Stroke for EVT- 2 yr Follow-Up

Huijberts I et al. Collateral-based selection for endovascular treatment of acute ischaemic stroke in the late window (MR CLEAN-LATE): 2-year follow-up of a phase 3, multicentre, open-label, randomise...

18 Okt 20246min

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