Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Avsnitt(386)

Episode 327: 326. Should We Prescribe Inhaled Insulin? INHALE-3 TRIAL

Episode 327: 326. Should We Prescribe Inhaled Insulin? INHALE-3 TRIAL

INHALE-3, a randomized trial, 123patients with type 1 dm that compared the efficacy of an inhaled insulin regimen (Afrezza) plus degludec insulin (Tresiba®) against usual care over 17 weeks The study'...

1 Aug 20247min

Episode 326: 325. The Mysterious NNT

Episode 326: 325. The Mysterious NNT

What is a quick and easy way to calculate the NNT

30 Juli 20247min

Episode 325: 324. METHODS MONDAY

Episode 325: 324. METHODS MONDAY

What is the different between Absolute and Relative risk reduction

29 Juli 20248min

Episode 324: 323. Is Calcium Bad For You? Calcium Supplementation? Eating Calcium?

Episode 324: 323. Is Calcium Bad For You? Calcium Supplementation? Eating Calcium?

https://heart.bmj.com/content/108/12/964https://www.ahajournals.org/doi/10.1161/JAHA.116.003815We have a study that says leads to increase all cause death with calcium supplementsWe have a study that ...

26 Juli 202413min

Episode 323: 322. Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention

Episode 323: 322. Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention

https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300311Peanut consumption, starting in infancy and continuing to age 5 years, provided lasting tolerance to peanut into adolescence irrespective of sub...

24 Juli 20245min

Episode 322: 321. Long-Term Outcomes in Patients with Low Risk Prostate Cancer

Episode 322: 321. Long-Term Outcomes in Patients with Low Risk Prostate Cancer

https://jamanetwork.com/journals/jama/article-abstract/2819352Conclusions and Relevance  In this study, 10 years after diagnosis, 49% of men remained free of progression or treatment, less than 2% dev...

23 Juli 20246min

Episode 321: 320. What is the Association of Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease

Episode 321: 320. What is the Association of Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179824/This study did something smart in that they broke it down by white black Chinese and then also had 36 lab test they were looking at and they then ...

19 Juli 20248min

Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?

Episode 320: 319. President Biden has COVID, Should the First Lady Take Paxlovid?

https://www.nejm.org/doi/full/10.1056/NEJMoa2309002In this placebo-controlled trial, postexposure prophylaxis with nirmatrelvir–ritonavir for 5 or 10 days did not significantly reduce the risk of symp...

18 Juli 20248min

Populärt inom Hälsa

somna-med-henrik
rss-jossan-nina
rss-bara-en-till-om-missbruk-medberoende-2
inga-beiga-morsor
alska-oss
johannes-hansen-podcast
not-fanny-anymore
rss-vuxna-pa-latsas
rss-viktmedicinpodden
sexnoveller-deluxe
angestpodden
sova-med-dan-horning
sa-in-i-sjalen
rss-psykoterapipodden
brottarbroder
giggles-med-wiggles
rss-aldrig-lagom
rss-basta-livet
rss-sjalsligt-avkladd
smartare-fitness-podden