Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Avsnitt(386)

Episode 287: 286. Does Hypokalemia cause Heart Badness?

Episode 287: 286. Does Hypokalemia cause Heart Badness?

https://onlinelibrary.wiley.com/doi/10.1111/joim.13757ECG abnormalities were present in 40% of hypokalemic patients and included t-wave flattening/inversion, ST-segment depression, QTc prolongation, l...

15 Maj 20245min

Episode 286: 285. Does Exercise Improve Hip OA?

Episode 286: 285. Does Exercise Improve Hip OA?

https://www.acpjournals.org/doi/10.7326/M23-3225researchers randomized 160 patients with mostly unilateral hip OA to two 60-minute sessions weekly for 12 weeks,you were randomized to receive either ne...

14 Maj 20245min

Episode 285: 284. Do Electronic Cigarettes Increase Smoking Cessation?

Episode 285: 284. Do Electronic Cigarettes Increase Smoking Cessation?

adult smokers who are given e-cigarettes are significantly more likely to be abstinent at 6 months from a target quit date with a  (NNT = 8) but those individuals were not more likely to be abstinent ...

13 Maj 20247min

Episode 284: 283. New Guidelines from American College of Cardiology on Atrial Fibrillation

Episode 284: 283. New Guidelines from American College of Cardiology on Atrial Fibrillation

However, screening is not recommended because it has not been shown to improve patient outcomes.. Lifestyle recommendations include moderating alcohol use, quitting smoking, exercising, and losing wei...

9 Maj 20248min

Episode 283: 282. New Guidelines For Management of Acute Pancreatitis

Episode 283: 282. New Guidelines For Management of Acute Pancreatitis

https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx2 of the 3 following criteria: (i) abdominal pain consistent with the disease, (ii) serum amyla...

3 Maj 20247min

Episode 282: 281. What Do You Do With Elevated Childhood Cholesterol?

Episode 282: 281. What Do You Do With Elevated Childhood Cholesterol?

Bottom line-Elevated cholesterol as a child into an adult is bad but we still don’t know if treating children with medication improves this badness but we can say if you have elevated cholesterol as a...

2 Maj 20246min

Episode 281: 280. How Much Weight Does an Obese Mother Need to Gain?

Episode 281: 280. How Much Weight Does an Obese Mother Need to Gain?

Weight gain <5 kg was not associated with risk for the composite outcome among women with class 1 and 2 obesity (BMIs, ≥30–39.9 kg/m2). Weight gain <5 kg and weight loss were associated with lower ris...

1 Maj 20245min

Episode 280: 279. Does Sitting In a Chair Improve Patient Stay in the Hospital?

Episode 280: 279. Does Sitting In a Chair Improve Patient Stay in the Hospital?

Chair placement was not associated with a difference in patients’ ability to name their physician (P=1.0), ability to successfully identify their reason for hospital admission (P=0.82), or perceptions...

29 Apr 20247min

Populärt inom Hälsa

somna-med-henrik
rss-jossan-nina
rss-bara-en-till-om-missbruk-medberoende-2
inga-beiga-morsor
alska-oss
johannes-hansen-podcast
not-fanny-anymore
rss-vuxna-pa-latsas
rss-viktmedicinpodden
sexnoveller-deluxe
angestpodden
sova-med-dan-horning
sa-in-i-sjalen
rss-psykoterapipodden
brottarbroder
giggles-med-wiggles
rss-aldrig-lagom
rss-basta-livet
rss-sjalsligt-avkladd
smartare-fitness-podden