Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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167. ADHD mothers, COVID and ACEI, Near Sighted Children

167. ADHD mothers, COVID and ACEI, Near Sighted Children

Autoimmune mothers likely don't actually have more ADHD kids. If you patient is in the hospital we now have a RCT to answer the question about ACEI starting or stopping. Finally, there are problems ar...

1 Feb 202119min

Episode 166: 166. Buprenorphine for Opioid Use Disorder

Episode 166: 166. Buprenorphine for Opioid Use Disorder

HHS Expands Access to Treatment for Opioid Use Disorder | HHS.govU.S. Department of Health and Human Services Announcement of practice guidelines for the administration of Buprenorphine for treating o...

27 Jan 202127min

165. Pulse Ox, Benzodiazepine, Unhealthy Lifestyle

165. Pulse Ox, Benzodiazepine, Unhealthy Lifestyle

They say every dog has its day and IT think every drug has its place Anyone who says ‘that drug is bad’ or that test is bad or that anything is bad is just being closed minded or not aware of the evid...

17 Jan 202121min

164. Listener Emails on Vit. D and COVID19

164. Listener Emails on Vit. D and COVID19

Dr sprouse-- Endo saying that Vit D below 30 leads to 2nd hyperparathyroidism due to calcium absorption deficiency and downstream consequences of that condition leads to poor bone health. He agreed al...

10 Jan 202123min

163. COVID19 Vaccine and Pregnancy

163. COVID19 Vaccine and Pregnancy

NEW covid19 vaccine I am sure many of you have heard it is the first of its kind. It uses mRNA technology. I am not going to discuss what that means ebcasue so many people already have on other podcas...

25 Dec 202017min

162. Movies, Pregnancy Pills, 2020 National Asthma Education

162. Movies, Pregnancy Pills, 2020 National Asthma Education

What you see is what you get- no more clearly seen then inThis paper titled Nutritional Analysis of Foods and Beverages Depicted in Top-Grossing US Movies, 1994-2018 In JAMA internal medicine which lo...

21 Dec 202024min

161. Hygia Chronotherapy and COVID-19 with Vitamin D

161. Hygia Chronotherapy and COVID-19 with Vitamin D

Get the best evidence because you want to know what they are looking at and occasionally people send me articles I was not aware of. Plus I ate spending my time sending them all the information then p...

16 Dec 202036min

160. 2020 Update to The Top Articles of 2019

160. 2020 Update to The Top Articles of 2019

2020 Update to The Top Articles of 2019

9 Dec 202024min

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