Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial
A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are desig...
1 Juli 202414min
Episode 310: 309. Hospital-Associated Venous Thromboembolism Prophylaxis Use by Risk Assessment
https://shmpublications.onlinelibrary.wiley.com/doi/abs/10.1002/jhm.13350Xu J et al. Hospital-associated venous thromboembolism prophylaxis use by risk assessment at a large integrated health care net...
28 Juni 20248min
Episode 309: 308. Mailed feedback to Primary Care Physicians on Antibiotic Prescribing
https://www.bmj.com/content/385/bmj-2024-079329Overprescription of antibiotics by primary care clinicians is a major modifiable driver of antibiotic resistance. Evidence suggests that peer-comparison ...
27 Juni 20247min
Episode 308: 307. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES)
Kityo C et al. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): Week 48 results from a randomised, multicentre, open-label, non-inferio...
25 Juni 20245min
Episode 307: 306. METHODS MONDAY! What is the 95% Confidence Interval?
95% CI does NOT mean there is a 95% chance the true value is in the interval. It means that if you continually resample, 95% of your confidence intervals (which will vary every time you resample), wil...
24 Juni 20248min
Episode 306: 305. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline
https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae290/7685305?login=trueChildren aged 1-18 years to prevent rickets and to potentially lower the risk for respiratory tract infection...
21 Juni 202414min
Episode 305: 304. METHODS MONDAY- What is Power?
What is the power of a study—what is the power calculation? Often say it is the number of people in a study. Power is the probably to correctly reject the null hypothesis. Said differently power is th...
17 Juni 202415min
Episode 304: 303. Associations Between Surrogate Markers and Clinical Outcomes
Question What is the strength of association between surrogate markers used as primary end points in clinical trials to support Food and Drug Administration (FDA) approval of drugs treating nononcolo...
14 Juni 20245min
