Episode 330: 328. Methods Monday, Composite Endpoints

Episode 330: 328. Methods Monday, Composite Endpoints

Composite outcomes

You add multiple outcomes together… this is great because you can increase the event rate.. if you are just looking at death lots of people might now die but if you look at death and hospitalizations well then it is easier to get to your expected event rate because its much easier to be hospitalized. This make it so you can have smaller sample sizes and it wont be nearly as expensive.

The problem is all the events are given the same importance and we know they are not the same importance to patients

Death and hospitalizations NOT THE SAME

PE and death—not the same

3 questions to asked.

Part of the endpoints of similar importance to patient's?

Due to the more or less significant endpoints occur with the same frequency?

Due to the endpoints share similar relative risk reductions?

Avsnitt(387)

Episode 401: 409. The Effects of Upper Extremity and Lower Extremity Aerobic Exercise Training in Patients with Peripheral Arterial Disease:

Episode 401: 409. The Effects of Upper Extremity and Lower Extremity Aerobic Exercise Training in Patients with Peripheral Arterial Disease:

Practice Pearls: “Skip Leg Day” (Sometimes)For PAD patients who can’t tolerate leg workouts, upper body aerobic training is a strong, evidence-backed alternative. It’s not just a workaround—it’s a wor...

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Episode 400: 408. CME Obesity and MASH

Episode 400: 408. CME Obesity and MASH

GLP1 drugs work but they likely need lifestyle modificationsNo convincing evidence GLP1 cause thyroid cancer in humans BUT contraindication if family history existStopping therapy usually results in w...

27 Sep 20251h 2min

Episode 399: 407. OMED COPD CME

Episode 399: 407. OMED COPD CME

OMED COPD CME

22 Sep 202539min

Episode 398: 406. Update of Medical Articles

Episode 398: 406. Update of Medical Articles

All of these articles have been talked about on questioning medicine social media on tik tok and instagram but here is an update of my recent reading

27 Aug 202529min

Episode 397: 405. 4 New Medical Articles That Are Deceiving

Episode 397: 405. 4 New Medical Articles That Are Deceiving

Buelt, Andrew | 2:13 PM (1 hour ago) |  | to mehttps://jamanetwork.com/journals/jama/fullarticle/2833338 Conclusions and Relevance  These results support use of metformin for treatment of symptomatic ...

1 Aug 202519min

Episode 396: 404. albuterol/budesonide, DOAC in 4 Days, Statins for AAA

Episode 396: 404. albuterol/budesonide, DOAC in 4 Days, Statins for AAA

https://www.nejm.org/doi/10.1056/NEJMoa2504544  During follow-up ranging from 12 to 52 weeks, fewer patients had severe exacerbations in the albuterol/budesonide group than in the albuterol group (5% ...

24 Juli 202512min

Episode 395: 403. COVID Maternal Booster And Cervical Self Swabs

Episode 395: 403. COVID Maternal Booster And Cervical Self Swabs

https://publications.aap.org/pediatrics/article/156/1/e2024070175/202234/Infant-Antibodies-After-Maternal-COVID-19?autologincheck=redirected  Objective:The study aimed to evaluate the kinetics and du...

22 Juli 202510min

Episode 394: 402. Cardiovascular Risk Factors, Zilebesiran, Shared Decision Making

Episode 394: 402. Cardiovascular Risk Factors, Zilebesiran, Shared Decision Making

https://www.nejm.org/doi/10.1056/NEJMoa2415879?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Key Findings: Classic Risk Factors: The five risk factors examined were hype...

18 Juli 202515min

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