2025 Biohacking State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann : 1243

2025 Biohacking State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann : 1243

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?

Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.

From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.

What You’ll Learn:

• The Seven Tenets of Aging and how they’ll change your approach to health

• Why indulging in “bad” habits doesn’t have to sabotage your longevity

• Biochemical secrets to combat oxidative stress, glycation, and cellular junk

• The real story behind NAD, circadian rhythms, and the tools for better sleep

• How to create a personalized health plan that’s sustainable, effective—and fun


Resources:

Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en

2025 Biohacking Conference: https://biohackingconference.com/2025

Kaufmann Protocol Website: https://kaufmannprotocol.com

Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047

Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en

Danger Coffee: https://dangercoffee.com

Dave Asprey’s Website: https://daveasprey.com

Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books

Dave Asprey’s Linktree: https://linktr.ee/daveasprey

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

Own an Upgrade Labs: https://ownanupgradelabs.com

Upgrade Labs: https://upgradelabs.com

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com


SPONSORS:

Leela Quantum | Head to https://leelaq.com/DAVE for 10% off.

Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.


Timestamps:

00:00 Trailer

00:45 Guest Introduction

02:30 Longevity Insights

04:22 Personal Stories

08:00 Pharmaceuticals

12:26 Diet and Lifestyle

18:19 Seven Tenets

22:04 Sleep and Circadian Rhythms

26:41 NAD and Supplements

37:46 Blood Sugar and AGEs

47:09 Microcirculation

49:08 NRS and Imports

49:18 Celebrex Medication

50:03 Celebrex Benefits

50:41 Alzheimer’s and Celebrex

51:28 Antioxidants

54:26 Stem Cells and Exosomes

58:03 Laser Skin Treatments

01:07:34 Hormones and Longevity

01:20:03 Lithium for Mood

01:27:45 Gender and Longevity

01:32:39 Final Thoughts

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Podcast #30: Sweet Potato Power with Ashley Tudor

Podcast #30: Sweet Potato Power with Ashley Tudor

Ashley Tudor is a Design Strategist with the Spruce Street Institute where she works to create innovations in healthcare for doctors, patients and kids. She has worked with a wide range of Fortune 500 companies on a variety of projects including envisioning the future of cars, finding new ways for people to invest their money, designing ways to help food companies fight obesity, and coming up with new medical devices for primary care physicians. Ashley was named one of San Francisco’s Top Innovators in Health in 2010.Aside from her business exploits, Ashley is the author of Sweet Potato Power, a book aimed at promoting what she believes to be one of the healthiest and most high performance foods you can eat.  Ashley comes on Upgraded Self Radio to talk about how you can use the power of sweet potatoes to look, feel, and perform better. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Aug 20121h 12min

Podcast #29: How Real Food Improves Your Performance with Joel Salatin

Podcast #29: How Real Food Improves Your Performance with Joel Salatin

Joel F. Salatin is an American farmer, lecturer, and author whose books include Folks, This Ain't Normal, You Can Farm, and Salad Bar Beef. Salatin raises livestock using holistic methods of animal husbandry, free from harmful chemicals, on his Polyface Farm in Swoope, Virginia, in the Shenandoah Valley. Joel joins us today to talk about his unique farming methods, and why they improve both your health, and the health of the animals. Click here to subscribe to the podcast in iTunes. Click here to read the free transcript of this episode (coming soon). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Juni 20121h 20min

Podcast #28: Monitoring Your Brain with Chris Berka

Podcast #28: Monitoring Your Brain with Chris Berka

Chris Berka is the CEO and Co-Founder at Advanced Brain Monitoring (ABM). She has over 25 years experience managing clinical research and developing and commercializing new technologies. Co-inventor of nine patented and 11 patent-pending technologies, Ms. Berka is the principal investigator or co-investigator for grants & contracts awarded by the National Institutes of Health, DARPA, ONR and NSF that provided more than $22 million of research funds to ABM. Chris Berka comes on Upgraded Self Radio to talk about how you can use advanced brain monitoring technology to improve your mental and physical performance. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Maj 20121h 18min

Podcast #27: Minding My Mitochondria with Dr. Terry Wahls, MD

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Podcast #26: Body By Science with Dr. Doug McGuff, MD

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Podcast #25: Wheat Belly with Dr. William Davis, MD

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Podcast #24: Becoming Awesome with Julien Smith

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Podcast #23: The Art of Less Doing with Ari Meisel

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