175 | William Ratcliff on Multicellularity, Physics, and Evolution

175 | William Ratcliff on Multicellularity, Physics, and Evolution

We've talked about the very origin of life, but certain transitions along its subsequent history were incredibly important. Perhaps none more so than the transition from unicellular to multicellular organisms, which made possible an incredible diversity of organisms and structures. Will Ratcliff studies the physics that constrains multicellular structures, examines the minute changes in certain yeast cells that allows them to become multicellular, and does long-term evolution experiments in which multicellularity spontaneously evolves and grows. We can't yet create life from non-life, but we can reproduce critical evolutionary steps in the lab.

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William Ratcliff received his Ph.D. in Ecology, Evolution, and Behavior at the University of Minnesota. He is currently Associate Professor in the School of Biological Sciences at Georgia Tech. Among his awards are a Packard Fellowship and being named in Popular Science's "Brilliant 10" of 2016.


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AMA | June 2025

AMA | June 2025

Welcome to the June 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreo...

2 Juni 20253h 23min

316 | Niayesh Afshordi and Phil Halper

316 | Niayesh Afshordi and Phil Halper

Einstein's general theory of relativity, plus some reasonable assumptions about the universe and what it's made of, has a remarkable implication: that as we trace cosmic evolution into the far past, w...

26 Maj 20251h 28min

315 | Branden Fitelson on the Logic and Use of Probability

315 | Branden Fitelson on the Logic and Use of Probability

Every time you see an apple spontaneously break away from a tree, it falls downward. You therefore claim that there is a law of physics: apples fall downward from trees. But how can you really know? A...

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314 | Karen Lloyd on the Deep Underground Biosphere

314 | Karen Lloyd on the Deep Underground Biosphere

There are living creatures dwelling deep below the surface of the Earth, as deep as we are able to drill. These hearty microorganisms are related to more familiar life forms on land and under water, b...

12 Maj 20251h 9min

313 | Eric Topol on the Changing Face of Medicine and Aging

313 | Eric Topol on the Changing Face of Medicine and Aging

Medical science is advancing at an astonishing rate. Today we talk with leading expert Eric Topol about two aspects of this story. First, the use of artificial intelligence in medicine, especially in ...

5 Maj 20251h 12min

AMA | May 2025

AMA | May 2025

Welcome to the May 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreon...

28 Apr 20253h 38min

312 | Thomas Levenson on the Mutual History of Humans and Germs

312 | Thomas Levenson on the Mutual History of Humans and Germs

The germ theory of disease is a crowning achievement of science, up there with modern physics, continental drift, and evolution via natural selection. (Even if there will always be cranky skeptics.) B...

21 Apr 20251h 31min

311 | Annaka Harris on Whether Consciousness is Fundamental

311 | Annaka Harris on Whether Consciousness is Fundamental

Questions about consciousness range from the precise and empirical -- what neurons fire when I have some particular experience -- to the deeply profound -- does consciousness emerge from matter, or do...

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