303 | James P. Allison on Fighting Cancer with the Immune System

303 | James P. Allison on Fighting Cancer with the Immune System

A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - to fight cancer? This is the hope of Nobel Laureate James Allison, who works on studying the structure and behavior of immune cells, and ways to coax them into fighting cancer. This approach offers hope of a way to combat cancer effectively, lastingly, and in a relatively gentle way.

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/

James P. Allison received his Ph.D. in biology from the University of Texas at Austin. He is currently Regental Professor and Chair of the Department of Immunology, the Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, and Director of the James P. Allison Institute at MD Anderson Cancer Center. He is the subject of the documentary film Jim Allison: Breakthrough. Among his numerous awards are the Breakthrough Prize in Life Sciences and the Nobel Prize in Physiology or Medicine.

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Avsnitt(437)

362 | Luis Bettencourt on the Universal Properties of Self-Organizing Cities

362 | Luis Bettencourt on the Universal Properties of Self-Organizing Cities

People who live in large cities produce more patents per person than those who live in small towns. They also walk faster down the street, and use less infrastructure per person. Indeed, the relations...

27 Juli 1h 20min

361 | Bonnie Bassler on How Bacteria Talk and Work Together

361 | Bonnie Bassler on How Bacteria Talk and Work Together

One of the characteristics of life is that living organisms gather information and put it to use. Even one of the simplest lifeforms, bacteria, are able to sense features of their surroundings and alt...

20 Juli 1h 15min

Mindscape Ask Me Anything, Sean Carroll | July 2026

Mindscape Ask Me Anything, Sean Carroll | July 2026

Welcome to the July 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreo...

13 Juli 4h 3min

360 | Marc Berman on the Science of Touching Grass

360 | Marc Berman on the Science of Touching Grass

Modern life has, in many ways, removed us from the environments in which our ancestors lived and adapted. Not only do we spend time looking at screens, but we spend time indoors, or outdoors but in ur...

6 Juli 1h 29min

359 | Solo: Theories of Dark Energy

359 | Solo: Theories of Dark Energy

The cosmological constant, as discussed last episode, provides a perfectly good (thus far) explanation for why we observe the universe to be accelerating. But it might not be the right explanation, an...

29 Juni 1h 56min

358 | Solo: Vacuum Energy and the Cosmological Constant

358 | Solo: Vacuum Energy and the Cosmological Constant

The most surprising discovery in fundamental physics during my career as a scientist was undoubtedly the acceleration of the universe, announced in 1998. The most straightforward explanation for these...

22 Juni 1h 59min

357 | Jeff Coller on mRNA, Vaccines, and Bespoke Therapeutics

357 | Jeff Coller on mRNA, Vaccines, and Bespoke Therapeutics

Messenger RNA (mRNA) plays a literally central role in the functioning of life as we know it, shuttling information back and forth between the DNA where it is stored to the ribosome where it is used t...

15 Juni 1h 19min

356 | Andrea Wulf on Enlightenment, Nature, Romanticism, and Modernity

356 | Andrea Wulf on Enlightenment, Nature, Romanticism, and Modernity

All ideas have a history, no matter how inevitable and well-entrenched they may seem to us today. The later Enlightenment was a heady time when people were exploring new conceptions of nature, humanit...

8 Juni 1h 17min

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