Hormonstörande kemikalier

Vi är omgivna av kemikalier som kan påverka vårt hormonsystem. Vilka risker innebär det för vår hälsa, vår reproduktion och vår framtid?

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Varningsropen duggar tätt. Luften vi andas, vattnet vi dricker, maten vi äter och produkter vi använder i vår vardag innehåller ämnen som kan orsaka allvarliga störningar av kroppens kemiska signalsystem. Men vad vet vi egentligen om riskerna? Hur fungerar hormonsystemet? Vad händer om det störs? Och går det att skydda sig mot något som finns överallt?

Producent och programledare: Viktor Hariz
Programledare: Anna Davour

Medverkande

• Shanna Swan - professor i miljömedicin och folkhälsovetenskap vid Icahn School of Medicine i New York

• Carl-Gustaf Bornehag - professor i folkhälsovetenskap vid Karlstads universitet

• Andreas Kortenkamp - professor i toxikologi vid Brunel University i London

• Anna Beronius - doktor i medicinsk vetenskap på institutet för miljömedicin vid Karolinska Institutet

• Leonardo Trasande - barnläkare och chef för Center for the Investigation of Environmental Hazards vid New York University

Vi har också pratat med Stéphane Horel, journalist på Le Monde

Artiklar

• Endocrine Disruptors: from Scientific Evidence to Human Health Protection (Europaparlamentet, 2019)

• State of the Science of Endocrine Disrupting Chemicals (WHO, 2012)

• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals (Gore et. al. 2015)

• Conceiving the Future - Anna Louie Sussman (NYROB, 2021)

• Why sounding the alarm on chemical contamination is not necessarily alarmist - Anthony Giddens (LRB, 1996)

• Internal emails reveal how the chemical lobby fights regulation - Emily Holden (The Guardian, 2019)

• A TOXIC AFFAIR - HOW THE CHEMICAL LOBBY BLOCKED ACTION ON HORMONE DISRUPTING CHEMICALS - Stephane Horel (CEO, 2015)

• Hormone disrupting chemicals: slow progress to regulation - Barbara Casassus (BMJ, 2018)

• Why endocrine disrupting chemicals (EDCs) challenge traditional risk assessment and how to respond - Fuhrman et. al (Journal of Hazardous Materials, 2015)

• EDCs: regulation still lagging behind evidence (Editorial, The Lancet Diabetes & Endocrinology 2019)

• Human exposure to synthetic endocrine disrupting chemicals (S‑EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S‑EDCs? - Autrup et. al (Archives of Toxicology, 2020)

• Human infertility: are endocrine disruptors to blame? - Marques-Pinto et. al. (Endocrine Connections, 2013)

• Soy, phytoestrogens and their impact on reproductive health Cederroth et. al. (Molecular and Cellular Endocrinology, 2012)

• Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification - La Merrill et. al. (Nature Reviews Endocrinology, 2020)

• Chemical Exposure Linked to Billions in Health Care Costs - Elisabeth Grossman (National Geographic, 2015)

• Substances identified as endocrine disruptors at EU level

• Endocrine disruptors in Europe: Nineteen ”experts” are polluting the debate - Stephane Horel et. al. (Le Monde, 2020)

• Whither the impending european regulation of presumed endocrine disruptors? Autrup et. al. (Regulatory Toxicology and Pharmacology, 2016)

• Endocrine disruption: Fact or urban legend? - Nohynek et. al. (Toxicology Letters, 2013)

• Non-linear endocrine no-dose effects—towards a new paradigm in toxicology (Satirartikel, Archives of Toxicology 2019)

• ‘Suppressed’ EU report could have banned pesticides worth billions - Arthur Neslen (EURACTIV, 2015)

• A path forward in the debate over health impacts of endocrine disrupting chemicals - Zoeller et. al. (Environmental Health, 2014)

• Paracetamol-induced endocrine disruption in human fetal testes - Bernard Jégou (Nature Reviews Endocrinology, 2015)

• Understanding conflicting views of endocrine disruptor experts: a pilot study using argumentation analysis - Clahsen et. al. (Journal of Risk Research, 2020)

• Vegetarian diet linked to genital defects - Matthew Hill (BBC, 1999)

• A maternal vegetarian diet in pregnancy is associated with hypospadias. The ALSPAC Study Team - North et. al. (BJU International, 2000)

• Testicular cancer incidence to rise by 25% by 2025 in Europe? Model-based predictions in 40 countries using population-based registry data (WHO, 2014)

• The pros and cons of phytoestrogens - Patisaul et. al. (Front Neuroendocrinol, 2010)

• Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data - Messina et. al. (Critical Reviews in Food Science and Nutrition, 2021)

• Lasting Impact of an Ephemeral Organ: The Role of the Placenta in Fetal Programming - Lindsey Konkel (Environmental Health Perspectives, 2016)

• Effects of the Endocrine-Disrupting Chemical DDT on Self-Renewal and Differentiation of Human Mesenchymal Stem Cells - Strong et. al. (Environmental Health Perspectives, 2015)

• Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort - Cirillo et. al. (Cancer Epidemiol Biomarkers, 2021)

• Long-Lasting Health Impacts of DDT Highlighted in New Study - Carey Gillam (Sierra, 2021)

• The Man Who Warned the World About Lead - CARRIE ARNOLD (PBS, 2017)

• EU puts 200 PFAS out of business – but thousands remain (CHEMSEC, 2021)

• Global breast cancer incidence and mortality trends by region, age-groups, and fertility patterns - Lima et. al. (The Lancet, 2021)

• Recent global trends in testicular cancer incidence and mortality - Park et. al. (Medicine, 2018)

• Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer - Milligan et. al. (J Clin Endocrinol Metab. 1999)

• The future of sperm: a biovariability framework for understanding global sperm count trends - Boulicault et. al. (Human Fertility, 2020)

• Estimating burden and disease costs of exposure to endocrine-disrupting chemicals in the European union - Trasande et. al. (J Clin Endocrinol Metab., 2015)

• Temporal trends in sperm count: a systematic review and meta-regression analysis - Levine et. al. (Human Reproduction Update, 2017)

• Paracetamol use during pregnancy — a call for precautionary action - Bauer et. al. (Nature Reviews Endocrinology, 2021)

• Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes - Repouskou et. al. (Scientific Reports, 2019)

• Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys - Bornehag et. al. (Environ Health Perspect. 2015)

Klipp och andra ljud

• EDCs and the EU (Endocrine Society, 2019)

• BPA and Circadian Rhythms (Endocrine Society, 2019)

• Endocrine Disruptors (Chemical Industries Association, 2015)

• Developmental Endocrine Disruption and Neurotoxicity - Marissa Sobolewski (Collaborative on Health and the Environment, 2021)

• Wold och Bornehag i debatt om plast (P4 Värmland, 2016)

• The Global Spermageddon (National Geographic, 2019)

• Endocrine System, Part 1 - Glands & Hormones: Crash Course A&P #23 (2015)

• Robert Sapolsky on Why We Behave the Way We Do (Sean Carroll's Mindscape, 2021)

• Doomsday for Pests (1946)

• Doomsday for Pests 2 (1946)

• Rachel Carson | American Experience | PBS (2017)

• Rare cancer traced to synthetic estrogen: Commemorating Arthur Herbst's breakthrough, DES Daughters (University of Chicago, 2011)

• Rätt att banta bort plast i hemmet? (Plånboken i P1, 2016)

Musik

• Podington Bear - Vibe Drive

• Martin D Fowler - Delaying the inevitable

• Kid Loco - Theme from the graffiti artist

• Cliff Martinez - Will she come back?

• Kronos Quartet - Galaxies

• Marcus Bagala - Untitledthingthing

• Paul Leonard Morgan - Odd

• Cliff Martinez - Not leaving this circus

• Cliff Martinez - Speight lived here

• Marcus Bagala - Boxes: Autumnal moping

• Cliff Martinez - I can't dig her our

• Ben Salisbury - Plainsong

• Cristobal Tapia De Veer - The Public

• Bela Bartok - Music for Strings, Percussion and Celesta, Sz. 106: 3. Adagio

• Marcus Bagala - Wires: Tangerines

• Trent Reznor & Atticus Ross - Clue One

• WOW MOM WOW - Tryptoreal

• Cliff Martinez - Dearest John

• Cliff Martinez - There's nothing here

• Vince Pope - A new home

• Marcus Bagala - Belle Ones

• Marcus Bagala - Cascading Bells

• Cliff Martinez - I got time

• Vince Pope - Fake

• Calexico - Untitled III (remix by Two Lone Swordsmen)

• Lorn - Unraveled

• Paul Leonard Morgan - Anderson's Theme

• Wojciech Golczewski - Setting up

• Michael McCann - The Mole

• Marcus Bagala - Frets: Problem after problem

• Vince Pope - Touching

• Viagra Boys - Research Chemicals