148: All Disease Begins In Your Gut: How to Stop Diseases in Their Tracks and Heal Yourself From Anything

Almost 2400 years ago, Hippocrates said "All disease begins in the gut"; and he was right. With modern scientific methods and studies to prove it, we can see exactly how and why all dieases begin in your gut, and what you can do to stop them.

93% od the leading causes of death are connected to your gut, and this episode is going to explain why that it, how it happens and to give you the tools you need to not only protect yourself and your loved ones, but even to reverse almost any diease.

TOPICS DISCUSSED:

• Reversing 93% of the leading causes of death
• The machanisms of how all diease begins in your gut
• How endotoxins (gut toxins) circulate around your body
• What they do to your organ systems and your body
• How to heal and seal your gut
• Reverse chronic inflammatory diseases
• How to heal from almost anything

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STUDIES FOR REFERENCE:

1. LPS and Liver Disease:

· Key Study: Lipopolysaccharides promote hepatic steatosis by activating the TLR4-NF-κB pathway in hepatocytes (Cai et al., 2012, Hepatology).

• Link: https://pubmed.ncbi.nlm.nih.gov/22025365/

2. LPS and Kidney Disease:

· Key Study: Role of lipopolysaccharide in the pathogenesis of kidney injury in sepsis (Matsushita et al., 2021, Nephrology).

• Link: https://pubmed.ncbi.nlm.nih.gov/33460487/

3. LPS and Diabetes:

· Key Study: Gut-derived endotoxin and metabolic inflammation in type 2 diabetes (Cani et al., 2007, Diabetologia).

• Link: https://pubmed.ncbi.nlm.nih.gov/17471239/

4. LPS and Cancer:

· Key Study: Gut microbiota-mediated inflammation in obesity: A link with gastrointestinal cancer (Cani et al., 2018, Nature Reviews Gastroenterology & Hepatology).

• Link: https://pubmed.ncbi.nlm.nih.gov/29348450/

5. LPS and Cerebrovascular Disease:

· Key Study: LPS-induced systemic inflammation exacerbates brain damage in ischemic stroke (Chen et al., 2016, Stroke).

• Link: https://pubmed.ncbi.nlm.nih.gov/26846899/

6. LPS and Parkinson's Disease:

· Key Study: Lipopolysaccharide induces neuroinflammation and dopaminergic neuron loss in Parkinson's disease models (Qin et al., 2007, Journal of Neuroscience).

• Link: https://pubmed.ncbi.nlm.nih.gov/17360907/

7. LPS and Hypertension:

· Key Study: Role of gut-derived endotoxemia in systemic inflammation and hypertension (Tang et al., 2017, Hypertension).

• Link: https://pubmed.ncbi.nlm.nih.gov/28209750/

8. LPS and Colon/Gut Diseases:

· Key Study: Lipopolysaccharides promote intestinal inflammation by disrupting the epithelial barrier (Schmidt et al., 2015, Gut).

• Link: https://pubmed.ncbi.nlm.nih.gov/25691570/

9. Studies Supporting LPS's Role in Alzheimer's:

· Study 1: Microbiome-derived lipopolysaccharide enriched in the perinuclear region of Alzheimer's disease brain (Zhao et al., 2017, Frontiers in Immunology).

• Link: https://pubmed.ncbi.nlm.nih.gov/28928740/

· Study 2: Lipopolysaccharides cause neuronal death and cognitive decline (Molecules, 2022).

• Link: https://pubmed.ncbi.nlm.nih.gov/35011994/

· Study 3: Neuroinflammation and Alzheimer's disease: Mechanisms of action (Nature Neuroscience, 2019).

• Link: https://pubmed.ncbi.nlm.nih.gov/30842661/