Your Brain on Cocaine - The SHOCKING Truth About Dopamine!

Your Brain on Cocaine - The SHOCKING Truth About Dopamine!

In this video, I uncover the secrets behind cocaine's manipulation of our dopamine system, which plays a pivotal role in reward, motivation, and addiction. Whether you're curious about the science or looking to understand the mechanics behind addiction, this video is your starting point.We'll explore how cocaine, in its many forms like cocaine hydrochloride, freebase, and crack, disrupts your brain's delicate balance. By blocking the dopamine transporter, cocaine creates a dopamine overload, leading to euphoria and stimulation. However, this seemingly pleasant effect harbors a darker consequence. Our deep dive doesn't stop at dopamine.We'll traverse various brain regions influenced by cocaine, witnessing its impact on the meso limbic system responsible for reward and reinforcement, and the mesocortical system overseeing decision making and impulse control. The stakes are high as we venture into the realms of stress and arousal, exploring how cocaine tips the balance and intensifies norepinephrine release, contributing to increased heart rates and blood pressure and significantly elevating the risks of heart attacks or strokes.Chapters00:00:00 Introduction and Overview 00:00:44 Cocaine and the Dopamine System 00:01:25 Mechanism of Action: Dopamine Transporter (DAT) Blockage00:02:24 Neurotransmitter Spillover: Serotonin and Norepinephrine 00:03:33 Cocaine's Effects on Reward Pathway 00:04:16 Role of the Nucleus Accumbens and Amygdala00:05:21 Hippocampus and Memory Formation 00:06:17 Decision Making and Impulse Control: Mesocortical System00:07:02 Motor System and Nigrostriatal Pathway 00:07:54 Stress and Arousal: Hypothalamus 00:08:00 Conclusion

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Special circumstances in OST Part 2

Special circumstances in OST Part 2

In episode 34 of Cracking Addiction we discuss how to manage some of the special circumstances in opioid substation therapy including OST in renal and hepatic impairment, managing polypharmacy complications with OST and managing acute pain whilst a patient is on OST.Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

6 Apr 202218min

Special circumstances in OST Part 1

Special circumstances in OST Part 1

In episode 33 of Cracking Addiction we discuss how to manage some of the special circumstances in opioid substation therapy including vomiting of doses of OST, dealing with intoxicated patients, overdoses of OST and transitioning between Methadone and Suboxone and vice versa.Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

30 Mars 202224min

Naloxone

Naloxone

In episode 32 of Cracking Addiction we discuss the harm reduction intervention of Naloxone and when to consider prescribing this medication, the benefits of take home naloxone and how it saves lives!Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

23 Mars 202221min

Harm Reduction

Harm Reduction

In episode 31 of Cracking Addiction we discuss the harm reduction interventions that we can implement for people who inject drugs to decrease the risks of morbidity and mortality.Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

16 Mars 202226min

Suboxone Part 2

Suboxone Part 2

In episode 30 of Cracking Addiction we discuss the different opioid receptors buprenorphine acts upon and the nature of these effects, the difference between agonists and antagonists, how to start a patient on Suboxone and how to monitor patients on Suboxone and adjust doses.Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

9 Mars 202222min

Suboxone Part 1

Suboxone Part 1

In episode 29 of Cracking Addiction we discuss Suboxone and talk about the components of Suboxone as well as the pharmacology and pharmacokinetics of Suboxone.Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

2 Mars 202218min

LAIB - Top Tips

LAIB - Top Tips

In episode 28 of Cracking Addiction we discuss our practical tips, advice and experience in managing patients on LAIB and share what we have learned.Discussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

23 Feb 202219min

LAIB The Patient Arc

LAIB The Patient Arc

Episode 27 of Cracking Addiction discusses the patient journey on LAIB and how to adequately deal with and manage adjusting doses of LAIB, commencing and ceasing LAIB and ensuring that patients are maintained on LAIB therapyDiscussions and comments in our videos are for informational purposes only and should not replace the advice of your medical professional. Please consult with your doctor before making any changes to your medical treatment or lifestyle.Latest Blogshttps://www.meducate.com.au/blogAbout Meducate ®Meducate provides online education for doctors, clinicians, health professionals and the public.See the website to browse the many different talks and courses available https://www.meducate.com.au

16 Feb 202215min

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