#93 - Sleeping Pills and their Alternatives with Dr. Ranji Varghese

#93 - Sleeping Pills and their Alternatives with Dr. Ranji Varghese

Matt Walker welcomes Dr. Ranji Varghese back to the podcast today to complete the whole sleeping pill story by discussing newer sleeping pills, beyond benzos and Z-drugs. Together, they explore Melatonin receptor agonists (like Ramelteon) that signal sleep preparation, unlike sedating GABAergics. They also detail how DORAs inhibit the wakefulness-promoting orexin, how off-label options (ex. trazodone, low-dose doxepin) affect histamine, the risks and benefits of each. Dr. Varghese goes ...

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#23: Dreams – Part 6

#23: Dreams – Part 6

In this episode, Matt goes deeper into his exploration of lucid dreaming. He tells us all about studies demonstrating that lucid dreamers can wake from dream sleep on command, demonstrating control over intention in their dreams, and even bring themselves to orgasm in dream sleep! Matt tells us about two leading methods for developing the skill of lucid dreaming. The first is Mnemonic Induction of Lucid Dreams, which involves the creation of a conscious, deliberate intention to remember...

6 Juni 202216min

#22: Dreams - Part 5

#22: Dreams - Part 5

In part five of his series on dreams, Matt discusses what lucid dreaming is and how it was scientifically proven to be real. We define lucid dreaming as the moment when an individual becomes aware they are dreaming. Historically, the concept of lucid dreaming was considered a scientific scam. First, to claim that people can gain conscious control over a normally unconscious process injects a heavy dose of ludicrous into the already preposterous experience we call dreaming. Second, how could a...

23 Maj 202213min

#21: Dreams - Part 4

#21: Dreams - Part 4

Today’s episode focuses on a second but very different function of dreaming: the ingenious processing and interconnection of memories that inspires creativity and even problem-solving ability. Matt describes how we can think of REM sleep dreaming as a form of informational alchemy, in which we build new connections. As a consequence, we wake the next morning with a mind-wide web of associations capable of divining solutions to previously impenetrable problems. A great illustration of dream-in...

9 Maj 202215min

#20: Dreams - Part 3

#20: Dreams - Part 3

Matt’s back with part three of his series on the science of dreaming! In this episode, he discusses how he and other scientists have discovered that dreams are not simply an unintended by-product of REM sleep. Instead, dreams provide at least two essential benefits for human beings. The first of these functions involves nursing our emotional and mental health and is the focus of this episode. Matt helps us understand that what makes a memory emotional is that, at the time of the experie...

25 Apr 202213min

#19: Dreams - Part 2

#19: Dreams - Part 2

In the second episode of this series about REM sleep dreaming, Matt explores what the science has to say not only about how we dream at the brain level, but what it is that we dream about. Traditionally, civilizations such as those in ancient Egypt, believed that dreams were a form of divine intervention--a message from the heavens. Thereafter, Matt discusses Sigmund Freud, who introduced the notion of dreams originating from within the brain, not the heavens, and thus could be conside...

11 Apr 202216min

#18: Dreams - Part 1

#18: Dreams - Part 1

This week’s episode is the first in a new multi-part series all about dreams! Today, Matt focuses on the question of how your brain generates these things called dreams. Matt starts with an unexpected statement: last night, when you were dreaming, you became psychotic. 5 things happen when you dream that justify his diagnosis: 1) you see things that aren’t there, 2) you believe things that could not be true, 3) you become confused about time, place, and person, 4) you have wildly fluctu...

28 Mars 202215min

#17: Sleep is Bloody Remarkable #1

#17: Sleep is Bloody Remarkable #1

Matt has a special announcement this week: a new recurring type of episode called, ‘Sleep is Bloody Remarkable’. This series of episodes will share fascinating facts about sleep that will blow your mind! In the premier episode, Matt focuses on something truly (bloody) remarkable: half-brain sleep, or unihemispheric sleep. Unihemispheric sleep is the phenomenon of when one hemisphere of the brain is awake, while the other sleeps. Matt goes on to discuss how the two sides of the b...

14 Mars 202213min

#16: Sleep & Weight Gain – Part 2

#16: Sleep & Weight Gain – Part 2

Matt returns with Part 2 of his series on sleep and weight gain. This time around, he teaches us how a lack of sleep not only makes you eat more food, but changes what types of food you want to eat, and eat to excess. First, Matt describes how underslept individuals that are limited to 4-5 hours of sleep for several nights will experience a 33% increase in the desire to eat obesogenic, sugary treats. In addition, they will suffer a 30% increase in craving for heavy-hitting carbohydrates, like...

28 Feb 202210min

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