Joint Action13 Apr 2025

The risk of bias in trial design and what this means for clinical practice with Dr Bruno da Costa

In this episode of Joint Action, Professor David Hunter is joined by Dr. Bruno da Costa, Associate Professor of Clinical Epidemiology at the University of Toronto and Senior Scientist at the University of Oxford, to unpack the evidence behind injections for osteoarthritis.

Dr. da Costa shares insights from his recent systematic review and network meta-analysis of clinical trials, revealing just how limited - and at times unreliable - the evidence is for many joint injection therapies.

This episode explores:

Which injections (if any) offer real benefit - and for how long
The surprising extent of bias in osteoarthritis trials
Why some results may not be as credible as they seem
The role of placebo effects and commercial influence
What this means for people living with osteoarthritis

If you’ve ever considered injection therapy, this episode will help you sort fact from fiction.

RESOURCES

S04E10 - Care for an oil change? The role of viscosupplementation for osteoarthritis wit Dr Bruno da Costa: https://www.jointaction.info/podcast/episode/6cda642b/care-for-an-oil-change-the-role-of-viscosupplementation-for-osteoarthritis-with-dr-bruno-da-costa
Infographic - How effective are intra-articular interventions for osteoarthritis?: https://www.osteoarthritisresearch.com.au/s/0225-Clinical-Editors-Choice.png
Article - Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomized trials: A systematic review and network meta-analysis: https://www.oarsijournal.com/article/S1063-4584(24)01389-X/fulltext

CONNECT WITH US

Twitter: @ProfDavidHunter @jointactionorg
Instagram: @osteoarthritisresearchgroup
Email: osteoarthritis.research@sydney.edu.au
Website: www.jointaction.info/podcast

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