313 | Eric Topol on the Changing Face of Medicine and Aging

Welcome to the October 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2023/10/09/ama-october-2023/Support Mindscape on Patreon.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Okt 20232h 58min

Our planet and its environment are in bad shape, in all sorts of ways. Those of us who want to improve the situation face a dilemma. On the one hand, we have to be forceful and clear-headed about how the bad the situation actually is. On the other, we don't want to give the impression that things are so bad that it's hopeless. That could -- and, empirically, does -- give people the impression that there's no point in working to make things better. Hannah Ritchie is an environmental researcher at Our World in Data who wants to thread this needle: things are bad, but there are ways we can work to make them better.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/10/02/252-hannah-ritchie-on-keeping-hope-for-the-planet-alive/Support Mindscape on Patreon.Hannah Ritchie received her Ph.D. in geosciences from the University of Edinburgh. She is currently Senior Researcher and the Head of Research at Our World in Data, and a researcher at the Oxford Martin Programme in Global Development at the University of Oxford. Her upcoming book is Not the End of the World: How We Can Be the First Generation to Build a Sustainable Planet.Web siteOxford web pageGoogle scholar publicationsSubstackWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Okt 20231h 15min

Biological organisms are paradigmatic emergent systems. That atoms of which they are made mindlessly obey the local laws of physics; even cells and organs do their individual jobs without explicitly understanding the larger whole of which they are a part. And yet the system as a whole functions beautifully, with apparent purpose and function. How do the small parts come together to form the greater whole? I talk with biophysicist Rosemary Braun about what we're learning about collective behavior within organisms from the modern era of huge biological datasets, especially crucial aspects like timekeeping (with bonus implications for dealing with jet lag).Support Mindscape on Patreon.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/09/25/251-rosemary-braun-on-uncovering-patterns-in-biological-complexity/Rosemary Braun received her Ph.D. in physics from the University of Illinois at Urbana-Champaign, and an M.P.H. in biostatistics from Johns Hopkins. She is currently an associate professor of molecular biosciences, applied math, and physics at Northwestern University and external faculty at the Santa Fe Institute.Lab web pageNorthwestern faculty pageGoogle Scholar publicationsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Sep 20231h 11min

The modern world inundates us with both information and misinformation. What are the forces that conspire to make misinformation so prevalent? Can we combat the flow of misinformation, perhaps by legal restrictions? Would that even be a good idea? How can individuals help distinguish between true and false claims as they come in? What are the biases that we are all subject to? I talk to political scientist Brendan Nyhan about how information and misinformation spread, and what we can do as individuals and as a society to increase the amount of truth we all believe.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/09/18/250-brendan-nyhan-on-navigating-the-information-ecosystem/Support Mindscape on Patreon.Brendan Nyhan received his Ph.D. in political science from Duke University. He is currently James O. Freedman professor of government at Dartmouth College. Among his awards are an Emerging Scholar award from the American Political Science Association, a Guggenheim Fellowship, and election to the American Academy of Arts and Sciences.Web siteDartmouth web pageGoogle Scholar publicationsWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Sep 202357min

The study of cognition and sentience would be greatly abetted by the discovery of intelligent alien beings, who presumably developed independently of life here on Earth. But we do have more than one data point to consider: certain vertebrates (including humans) are quite intelligent, but so are certain cephalopods (including octopuses), even though the last common ancestor of the two groups was a simple organism hundreds of millions of years ago that didn't have much of a nervous system at all. Peter Godfrey-Smith has put a great amount of effort into trying to figure out what we can learn about the nature of thinking by studying how it is done in these animals with very different brains and nervous systems.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/09/11/249-peter-godfrey-smith-on-sentience-and-octopus-minds/Support Mindscape on Patreon.Peter Godfrey-Smith received his Ph.D. in philosophy from the University of California, San Diego. He is currently professor in the School of History and Philosophy of Science at the University of Sydney. Among his books are Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness and Metazoa: Animal Life and the Birth of the Mind.Web siteUniversity of Sydney web pageGoogle Scholar publicationsPhilPeople profileWikipediaAmazon author pageHere are some of the papers mentioned in this episode:Crook (2021), Octopus painGibbons et al. (2022), Bee painGutnick et al. (2011), Octopus arm behaviorSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Sep 20231h 28min

Welcome to the September 2023 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2023/09/04/ama-september-2023/And you can now pre-order The Biggest Ideas in the Universe Vol. 2: Quanta and Fields!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Sep 20234h 3min

Over the last year, AI large-language models (LLMs) like ChatGPT have demonstrated a remarkable ability to carry on human-like conversations in a variety of different concepts. But the way these LLMs "learn" is very different from how human beings learn, and the same can be said for how they "reason." It's reasonable to ask, do these AI programs really understand the world they are talking about? Do they possess a common-sense picture of reality, or can they just string together words in convincing ways without any underlying understanding? Computer scientist Yejin Choi is a leader in trying to understand the sense in which AIs are actually intelligent, and why in some ways they're still shockingly stupid.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/08/28/248-yejin-choi-on-ai-and-common-sense/Support Mindscape on Patreon.Yejin Choi received a Ph.D. in computer science from Cornell University. She is currently the Wissner-Slivka Professor at the Paul G. Allen School of Computer Science & Engineering at the University of Washington and also a senior research director at AI2 overseeing the project Mosaic. Among her awards are a MacArthur fellowship and a fellow of the Association for Computational Linguistics.University of Washington web pageGoogle Scholar publicationsWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Aug 20231h 12min

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/08/21/247-samuel-bowles-on-economics-cooperation-and-inequality/Economics, much like thermodynamics, is a story of collective behavior arising from the interactions of many individual constituents. The big difference is that in economics, the constituents are themselves complicated human beings with their own goals and limitations. We can still make progress by positing some simple but plausible axioms governing human behavior, and proving theorems about what those axioms imply, such as the famous supply-and-demand curves. The trick is picking the right axioms that actually do apply to any given situation. Samuel Bowles is a highly regarded economist who has helped understand the emergence of political hierarchy and economic inequality, often drawing on wide-ranging ideas from game theory and evolutionary biology. We talk about how people evolved to cooperate, and why nevertheless inequality seems to be ubiquitous.Support Mindscape on Patreon.Samuel Bowles received a Ph.D. in economics from Harvard University. He has taught at Harvard University, the University of Massachusetts at Amherst, and the University of Siena, and he is currently Director of the Behavioral Sciences Program at the Santa Fe Institute. He has been awarded a Guggenheim Fellowship and the Leontief Prize, and is a fellow of the American Academy of Arts and Sciences. He is one of the developers of the CORE Econ project.Web pageGoogle Scholar publicationsWikipediaAmazon author pageSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Aug 20231h 20min