Individual Variation in Tirzepatide Response | JACC Deep Dive
JACC This Week13 Maj 2025

Individual Variation in Tirzepatide Response | JACC Deep Dive

Join JACC Editor in Chief Harlan Krumholz, MD, SM, as he speaks about this ACC.25 presentation published in JACC. This fascinating study by Rohan Khera et al independently analyzed patient-level data from the SURMOUNT trials of tirzepatide for obesity. The study revealed striking individual variability in weight loss and metabolic response, even to a highly effective therapy—an insight powerfully illustrated through waterfall plots. Reviewers praised the transparent, sponsor-independent approach and the study's contribution to precision medicine, though they noted it was descriptive rather than predictive, underscoring the need for future research to identify what drives differential treatment response.

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Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

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March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

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February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

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