#508: Program Your Own Computer with Python

#508: Program Your Own Computer with Python

If you've heard the phrase "Automate the boring things" for Python, this episode starts with that idea and takes it to another level. We have Glyph back on the podcast to talk about "Programming YOUR computer with Python." We dive into a bunch of tools and frameworks and especially spend some time on integrating with existing platform APIs (e.g. macOS's BrowserKit and Window's COM APIs) to build desktop apps in Python that make you happier and more productive. Let's dive in!

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#534: diskcache: Your secret Python perf weapon

#534: diskcache: Your secret Python perf weapon

Your cloud SSD is sitting there, bored, and it would like a job. Today we’re putting it to work with DiskCache, a simple, practical cache built on SQLite that can speed things up without spinning up R...

13 Jan 1h 14min

#533: Web Frameworks in Prod by Their Creators

#533: Web Frameworks in Prod by Their Creators

Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in production. Deployment patterns, async gotchas, serve...

5 Jan 1h 1min

#532: 2025 Python Year in Review

#532: 2025 Python Year in Review

Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packaging is getting sharper tools, and the type checkers are multiplying like gremlins snacking after midnight. On t...

29 Dec 20251h 18min

#531: Talk Python in Production

#531: Talk Python in Production

Have you ever thought about getting your small product into production, but are worried about the cost of the big cloud providers? Or maybe you think your current cloud service is over-architected and...

18 Dec 20251h 21min

#530: anywidget: Jupyter Widgets made easy

#530: anywidget: Jupyter Widgets made easy

For years, building interactive widgets in Python notebooks meant wrestling with toolchains, platform quirks, and a mountain of JavaScript machinery. Most developers took one look and backed away slow...

13 Dec 20251h 11min

#529: Computer Science from Scratch

#529: Computer Science from Scratch

A lot of people building software today never took the traditional CS path. They arrived through curiosity, a job that needed automating, or a late-night itch to make something work. This week, David ...

3 Dec 20251h 17min

#528: Python apps with LLM building blocks

#528: Python apps with LLM building blocks

In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another API in your Python app, with clear boundaries, small focused endpoints, and good monitoring. We’ll dig into patt...

30 Nov 20251h 16min

#527: MCP Servers for Python Devs

#527: MCP Servers for Python Devs

Today we’re digging into the Model Context Protocol, or MCP. Think LSP for AI: build a small Python service once and your tools and data show up across editors and agents like VS Code, Claude Code, an...

10 Nov 20251h 6min

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