1.7 DeepDive Neurobiology of Delusions & Hallucinations : Dr Bhaskar Mukherjee

Summary

Dr. Bhaskar Mukherjee discusses the normal functioning of the brain and how it responds to various challenges. He explains the evolutionary perspective of the brain and its role in controlling the body's internal environment. The brain continuously adjusts and adapts to changes in the external and social environment. Dr. Mukherjee also highlights the importance of understanding normal brain function before discussing pathology. This part of the conversation explores the normal physiology and pathology of the brain, specifically focusing on delusion and hallucination formation. It discusses the distinction between illness behavior and depression, as well as the role of personal opinions in psychosis. The chapters also delve into the neuroscience behind delusion and hallucination, including the executive function, motivation, and reward circuits. The molecular basis of these phenomena is explored, along with the cellular metabolic profile and neuronal vulnerability. Additionally, the role of neuroanatomical defects, glial support, and the innate immune system is examined. The conversation concludes with a discussion on the molecular surveillance pathway and its connection to cancer. In this conversation, Dr. Bhaskar Mukherjee discusses the molecular pathogenesis of psychiatric disorders, highlighting the role of neuronal activity and genetic abnormalities. He explains the connection between psychiatric symptoms and the development of malignancies, emphasizing the importance of molecular surveillance genes. The conversation then delves into the understanding of obsessive-compulsive and attention deficit traits, challenging the traditional diagnostic approach. Dr. Mukherjee also addresses the conundrum of emotionally unstable personality disorder (EUPD) and the need for a comprehensive treatment approach. The conversation concludes with a call for humility and continuous learning in the field of psychiatry.

Chapters

00:00 Introduction and Background

05:30 Basic Working Knowledge of the Brain

12:42 Normal Functioning of the Brain

15:18 Psychosis and Development of Symptoms

37:09 Moving towards Pathology

38:06 Differentiating Illness Behavior and Depression

39:04 Psychosis and Personal Opinions

42:03 The Basis of Delusion

43:14 Hallucinations and Sensory Perception Abnormalities

47:19 Visual and Auditory Systems

51:20 Neuroscience of Delusion and Hallucination

52:50 Executive Function, Motivation, and Reward Circuits

56:48 Molecular Basis of Delusion Formation

01:00:16 Normal Physiology and Pathology

01:01:43 Neurobiological Basis of Delusion and Hallucination

01:03:22 Molecular Neuroscience and Brain Complexity

01:04:14 Cellular Metabolic Profile and Neuronal Vulnerability

01:06:12 Neuroanatomical Defects and Glial Support

01:09:26 Misdirected Synapses and Innate Immune System

01:17:11 Pacemakers and Intracellular Molecular Front

01:19:09 Molecular Surveillance Pathway and Cancer

01:20:40 Molecular Pathogenesis of Psychiatric Disorders

01:25:42 Understanding Obsessive-Compulsive and Attention Deficit Traits

01:44:08 Challenges in Diagnosing and Treating Emotionally Unstable Personality Disorder (EUPD)

01:58:30 The Need for a Comprehensive Treatment Approach in Psychiatry

02:01:28 The Importance of Humility and Continuous Learning in Psychiatry