A Grand, Unified Theory of Why Americans Are So Unhealthy

A Grand, Unified Theory of Why Americans Are So Unhealthy

Americans are unusually overweight and chronically ill compared to similarly rich countries. This episode presents a grand, unified theory for why that's the case. Our food environment has become significantly more calorie-rich and industrialized in the past few decades, sending our obesity rates soaring, our visceral fat levels rising, and our chronic inflammation surging. The result is an astonishing rise in chronic illness in America. That's the bad news. The good news is that GLP-1 drugs, like Ozempic and Zepbound, seem to be astonishingly successful at reversing many of these trends. This episode blends two interviews with Dr. David Kessler and Dr. Eric Topol. Kessler was the commissioner of the Food and Drug Administration under the Bush and Clinton administrations, from 1990 to 1997. He helped lead Operation Warp Speed in its final months. He is the author of the book 'Diet, Drugs, and Dopamine.' Topol is a cardiologist and the founder and director of the Scripps Research Translational Institute. He is the author of the book 'Super Agers.' If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: Dr. David Kessler and Dr. Eric Topol Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Michael Lewis on How the Global Financial Crisis Explains Trump, Crypto, and Everything Else

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What Happens When AI Learns to Do Our Jobs

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Everybody Thinks AI Is a Bubble. What If They’re Wrong?

Everybody Thinks AI Is a Bubble. What If They’re Wrong?

Two weeks ago, in one of our most popular podcasts of the year, the investor and author Paul Kedrosky explained why he thinks AI is a bubble. In the last few days, practically everybody seems to agree...

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The Future of Entertainment, Part 2: What’s the Matter With Broadway?

The Future of Entertainment, Part 2: What’s the Matter With Broadway?

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The Future of Entertainment, Part 1: Is Hollywood's Business Model Broken?

The Future of Entertainment, Part 1: Is Hollywood's Business Model Broken?

The film and TV business has quietly—or, if you work in the industry, not so quietly—been in a depression for the past few years. Original TV work has plummeted. In 2024, Americans bought about 40 per...

10 Okt 202546min

Why Money Doesn't Buy Happiness in America

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America is rich—richer than ever. Yet Americans are more anxious, lonelier, and less satisfied than people in many poorer nations. The 2025 World Happiness Report ranked the U.S. 24th in life satisfac...

7 Okt 202548min

Is AI Really About to Solve Human Disease?

Is AI Really About to Solve Human Disease?

I’ve had the privilege of talking to many brilliant people about artificial intelligence. And when you ask them to imagine the most beneficial consequences of this technology, they almost always give ...

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