58 - The Original (Antigenic) Sin
Bedside Rounds26 Okt 2020

58 - The Original (Antigenic) Sin

The COVID-19 pandemic laid bare the racial health disparities in the United States, with markedly increased mortality especially among Blacks and Native Americans. In this episode, Tony Breu and I discuss the conception of race, racism, and the social determinants of health through three historic plagues in the United States -- from yellow fever in New Orleans, to poliomyelitis, and finally the early days of HIV/AIDS -- and what lessons we can draw for COVID-19. Along the way, we'll discuss the unique social capital afforded by acclimation, immunity passports, the concept of the "original antigenic sin," and constitutionalism and eugenics. This presentation was performed live at the annual meeting of the Massachusetts American College of Physicians, and is only lightly edited.

SOURCES:

  • Monath TP, Yellow fever: an update. Lancet Infect Dis. 2001 Aug;1(1):11-20. doi: 10.1016/S1473-3099(01)00016-0.
  • Kallas EG, D'Elia Zanella LGFAB, Moreira CHV, Buccheri R, Diniz GBF, Castiñeiras ACP, Costa PR, Dias JZC, Marmorato MP, Song ATW, Maestri A, Borges IC, Joelsons D, Cerqueira NB, Santiago E Souza NC, Morales Claro I, Sabino EC, Levi JE, Avelino-Silva VI, Ho YL. Predictors of mortality in patients with yellow fever: an observational cohort study. Lancet Infect Dis. 2019 Jul;19(7):750-758. doi: 10.1016/S1473-3099(19)30125-2. Epub 2019 May 16. Erratum in: Lancet Infect Dis. 2019 Nov;19(11):e370. PMID: 31104909.
  • Blake LE, Garcia-Blanco MA. Human genetic variation and yellow fever mortality during 19th century U.S. epidemics. mBio. 2014 Jun 3;5(3):e01253-14. doi: 10.1128/mBio.01253-14. PMID: 24895309; PMCID: PMC4049105.
  • Jelili Ojodu, MPH1, Mary M. Hulihan, MPH2, Shammara N. Pope, MPH2, Althea M. Grant, PhD2,, MMWR, Incidence of Sickle Cell Trait — United States, 2010.
  • IthaMaps, Haemoglobin Epidemiology. https://www.ithanet.eu/db/ithamaps?country=GR
  • Serjeant GR, The natural history of sickle cell disease. Cold Spring Harb Perspect Med. 2013 Oct; 3(10): a011783.
  • Hamosh A, FitzSimmons SC, Macek M Jr, Knowles MR, Rosenstein BJ, Cutting GR. Comparison of the clinical manifestations of cystic fibrosis in black and white patients. J Pediatr. 1998 Feb;132(2):255-9. doi: 10.1016/s0022-3476(98)70441-x. PMID: 9506637.
  • Gershman KD et al, Yellow Fever Vaccine & Malaria Prophylaxis Information, by Country. CDC.
  • Kofler N and Baylis F, Ten reasons why immunity passports are a bad idea. Nature 21 May 2020.
  • NASEM, National Academies Release Framework for Equitable Allocation of a COVID-19 Vaccine for Adoption by HHS, State, Tribal, Local, and Territorial Authorities.
  • Schmidt H et al, Covid-19: how to prioritize worse-off populations in allocating safe and effective vaccines.BMJ 2020; 371 doi: https://doi.org/10.1136/bmj.m3795 (Published 05 October 2020).
  • Siegal FP, Lopez C, Hammer GS, Brown AE, Kornfeld SJ, Gold J, Hassett J, Hirschman SZ, Cunningham-Rundles C, Adelsberg BR, et al. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med. 1981 Dec 10;305(24):1439-44. doi: 10.1056/NEJM198112103052403. PMID: 6272110.
  • Lushniak BD, Surgeon General's Perspectives. Public Health Rep. 2014 Mar-Apr; 129(2): 112–114.
  • Booske BC et al, "Different Perspectives For Assigning Weights to Determinants of Health," University of Wisconsin Population Health Institute.
  • Marc LG et al,HIV among Haitian-born persons in the United States, 1985–2007, AIDS. Author manuscript; available in PMC 2011 Aug 24.
  • Rogers N, Race and the Politics of Polio: Warm Springs, Tuskegee, and the March of Dimes. Am J Public Health. 2007 May; 97(5): 784–795.
  • Curran JW and Jaffe HW, AIDS: the Early Years and CDC's Response. MMWR.
  • Olivarius Kathryn, Immunity, Capital, and Power in Antebellum New Orleans. The American Historical Review, Volume 124, Issue 2, April 2019, Pages 425–455,

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(86)

74 - R2D2

74 - R2D2

What does it mean when a computer can make better medical decisions than a human? The progress in large language models, and in particular the popularity of ChatGPT, has brought these questions to the...

3 Sep 202333min

73 - Seadragon

73 - Seadragon

What happens when a patient far from surgical care – say, at the bottom of the Pacific ocean on a submarine, or at a research base in Antarctica in the middle of the winter – develops a surgical abdom...

26 Juni 202327min

72 - Problems

72 - Problems

American doctors spend the majority of their time during the day on the computer, either writing or reading notes about their patients; only a small fraction is spent with the human beings in their ca...

20 Mars 202352min

71 - A Doctor's Work, part 2

71 - A Doctor's Work, part 2

In the past episode, cultural and medical historians Lakshmi Krishnan and Mike Neuss discussed the history of the actual work of the doctor – Holmesian detective, data entry clerk, or something else a...

16 Jan 202337min

70 - A Doctor's Work

70 - A Doctor's Work

What do doctors actually do? Are they Sherlockian detectives, hunting down obscure clues to solve intractable cases? Are they virtuosic experts, training for half a lifetime to bring the latest scienc...

19 Dec 202249min

69 - The Database

69 - The Database

How do doctors actually think? And if we can answer that, can we train a computer to do a better job? In the post-WW2 period, a group of iconoclastic physicians set about to redefine the nature and st...

31 Okt 202248min

68 - The History

68 - The History

Internal medicine physicians like to pride ourselves on our clinical reasoning – the ability to talk to any patient, pluck out seemingly random bits of information, and make a mystery diagnosis. But h...

25 Juli 202239min

The Facemaker with Dr. Lindsey Fitzharris (#histmedconsultservice)

The Facemaker with Dr. Lindsey Fitzharris (#histmedconsultservice)

Modern plastic surgery was born out of the horrors of trench warfare in World War I. In this episode, Adam interviews historian Lindsey Fitzharris about her new book The Facemaker, about the life of s...

7 Juni 202251min

Populärt inom Hälsa

somna-med-henrik
inga-beiga-morsor
rss-jossan-nina
rss-bara-en-till-om-missbruk-medberoende-2
johannes-hansen-podcast
rss-vuxna-pa-latsas
not-fanny-anymore
sexnoveller-deluxe
angestpodden
rss-viktmedicinpodden
sova-med-dan-horning
rss-the-house-podcast-3
sa-in-i-sjalen
brottarbroder
rss-basta-livet
rss-sjalsligt-avkladd
rss-traningsklubben
sag-det-bara
rss-hos-psykologen
rss-the-house-podcast-4