Moderna and Flagship Pioneering: Noubar Afeyan

As he started to gain a name as a New York fashion designer in the 2010s, Telfar Clemens often joked that he was "constantly emerging." At least, that's how the establishment fashion press saw him: a child of Liberian immigrants, building a small but devoted following with his deconstructed T-shirts and sandals made from hollowed-out Converse. But after Telfar partnered with Babak Radboy as his creative director in 2013, the brand began to reach a wider audience. There were splashy partnerships with K-Mart and White Castle; and in 2018, the wide release of the Telfar Bag, a vegan-leather shopping bag that became the "it"-accessory for everyone from A-list celebrities to the neighbors next door. Today, Telfar and Babak say they've succeeded by designing exactly what they want—and sidestepping a fashion system that was not always welcoming. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Feb 20221h 17min

As a young programmer in the mid-2000s, Otis Chandler watched as dozens of niche web sites began to take off. When he decided to launch his own site just for book lovers, a respected colleague told him there was "probably not a very big market there." Otis figured he might prove him wrong, and in 2007, launched Goodreads, a book catalog and review site that he coded from his LA apartment. His soon-to-be-wife Elizabeth joined the project, and they slowly built a following—without an office, a business model, or a single employee. In 2013, Goodreads sold to Amazon for an undisclosed sum; and today, it's the world's largest site for readers, with 125 million users. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Feb 20221h 9min

Most entrepreneurs expect it will take at least a few years for their businesses to gain traction. But Tim Leatherman waited 7 years to make a single, $175 sale. In the late 1970s, he had set up shop in his brother-in-law's garage, scavenged some metal from old appliances, and built a tool that he'd dreamed up a few years before: a foldable pair of pliers with several other tools tucked into the handles. Tim worked for years trying to market his design to knife and tool companies, but none of them were interested. Was it a tool? A gadget? A knife? Eventually he was able to convince mail-order catalogs to sell the tool; and within the space of a decade, he went from selling a single knife to a million every year. Today Tim's company is worth over a $100 million and his last name has become a household brand: the Leatherman. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Jan 20221h 4min

Vincent Kitirattragarn grew up in a Thai-Chinese-American household, which meant eating congee and lemongrass chicken, while also ordering chicken McNuggets with his younger brothers. He dreamed of opening his own Thai restaurant, but an exhausting stint working at one convinced him that his entrepreneurial path would never be in the restaurant industry. Instead Vincent's Asian-inspired snack food brand, Dang Foods, was born in 2011 when a delicious home-cooking experiment led him to start importing coconut chips from Thailand. Vincent's brother Andrew joined a few years later to help grow the brand through a series of snack product successes—and some tasty but colossal flops. Today, the company sells their brightly-packaged coconut chips, rice crackers, and energy bars in over 10,000 stores across the country. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Jan 20221h 7min

In the 1980s—the early days of cable television—John Hendricks got stuck on an idea he couldn't shake: to create a channel that would teach people cool things in an entertaining way. In college he had seen hours of documentaries on history, science, and outer space; and he figured if he was interested in them, others would be too. So around the age of 30, he left a comfortable consulting business to begin a delicate juggling act: leasing a satellite, licensing content, and wooing cable distributors, all the while pounding the pavement to finance it all. Today, Discovery reaches more than 400 million homes around the world, and John is still in the content business, having launched Curiosity Stream in 2015. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Jan 20221h 13min

When she was working corporate jobs in New York City, Sarah LaFleur hated getting dressed in the morning; the choices in her closet felt overwhelming, many items didn't fit right or wore out too quickly. So in 2011 she launched a line of clothing for working women that would be simple, elegant, and well-tailored. She had no experience in fashion but partnered with a top-line designer, Miyako Nakamura, to create M.M.LaFleur. Today it's a multi-million dollar company with loyal customers from Capitol Hill to Silicon Valley. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Jan 20221h 8min

Andy Puddicombe is not your typical entrepreneur—in his early twenties, he gave away everything he owned to train as a Buddhist monk. But after ten years, he decided he wanted to bring the benefits of his meditation techniques to more people. While running a meditation clinic in London, Andy met Rich Pierson, who had burned out on his job at a high-powered London ad agency. Together, they founded Headspace in 2010. Over ten years later, Headspace's guided meditation app has users in 190 countries and an annual revenue of over $100 million. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Jan 20221h 8min

Kathleen King was 11 years old when she started baking cookies to sell at her family's farm stand on Long Island. After college, she opened a small bake shop, and eventually started selling her cookies to gourmet grocery stores in Manhattan. But after twenty years of running a small business, she wanted more time for herself. She brought in two partners to grow sales, but the partnership was a disaster—and after bitter lawsuits, Kathleen was forced to start over from scratch. 18 years later, Tate's Bake Shop—the second cookie brand that she built out of the crumbs of the first—sold for $500 million. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Dec 202156min