Moderna and Flagship Pioneering: Noubar Afeyan

In 2000, Lara Merriken was 32, recently divorced, and without a job when she decided to make energy bars by mixing cherries, dates, and almonds in her Cuisinart. Eventually, she perfected the recipe and launched her company: LÄRABAR. After just two years, the company was bringing in millions in revenue. In 2008, she sold to General Mills, but stayed on to help grow LÄRABAR into one of the biggest energy bar brands in the U.S. Plus, for our postscript "How You Built That", how two brothers from Guinea, West Africa founded a company that makes Ginjan, a spicy-sweet juice from their boyhood, which mixes pineapple and ginger. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Mars 201853min

When Carley Roney and David Liu got married, they had a seat-of-the-pants celebration on a sweltering Washington rooftop. They never planned to go into the wedding business, but soon saw an opportunity in the market for a fresh approach to wedding planning. In 1996, they founded The Knot, a website with an irreverent attitude about "the big day." The Knot weathered the dot.com bust, a stock market meltdown, and eventually grew into the lifestyle brand XO Group, valued at $500 million. PLUS for our postscript "How You Built That," how Michael Dixon's business, Mobile Vinyl Recorders, uses portable record lathes to cut vinyl at parties, weddings, and music festivals. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Mars 201854min

Brian Scudamore didn't dream of a life hauling away other people's trash. But when he needed to pay for college, he bought a $700 pickup truck, painted his phone number on the side, and started hauling. Now 1-800-GOT-JUNK? makes close to $300 million in annual revenue. PLUS for our postscript "How You Built That," an update on Bloomerent, an online service that helps couples save wedding costs by letting them share flower arrangements on the same weekend. (Original broadcast date: April 17, 2017) See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Mars 201840min

Even as a kid, Jeni Britton Bauer knew she was going to start a business one day. But she had no idea that her love for perfume would inspire her to start experimenting with ice cream. After years of hustling, she eventually launched Jeni's Splendid Ice Creams, a company that now has more than 30 stores nationally and touts unique flavors like Brambleberry Crisp and Lemon Buttermilk. Recorded live in Columbus, Ohio. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Feb 201846min

During the dot com boom of the late 1990s, Jimmy Wales was running an internet search company. That's when he began to experiment with the idea of an online encyclopedia. In 2001, Wales launched Wikipedia, a website where thousands of community members could contribute, edit, and monitor content on just about anything. Today, the non-profit has stayed true to its open source roots and is the fifth most visited website in the world. PLUS in our postscript "How You Built That," how Florence Wetterwald created Blabla dolls – eco-friendly knitted dolls made in Peru. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Feb 201841min

In 2008, it was nearly impossible to buy a fashionable, affordable pair of glasses online. That simple frustration inspired the idea behind Warby Parker – and disrupted the eyewear industry. PLUS for our postscript "How You Built That," an update on Bellyak, a kayak where you lie on your belly and paddle with your hands. (Original broadcast date: December 26, 2016) See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Feb 201831min

In 1979, James Dyson had an idea for a new vacuum cleaner — one that didn't use bags. It took him five years to perfect the design, building more than 5,000 prototypes in his backyard shed. He then tried to convince the big vacuum brands to license his invention, but most wouldn't even take his calls. Eventually, he started his own company. Today, Dyson is one of the best-selling vacuum brands in the world, and James Dyson is a billionaire. PLUS for our postscript "How You Built That," how Theresa Stotesbury made a business out of fake blood — a synthetic material that helps create a realistic crime scene for police training. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Feb 201842min

Melissa and Doug Bernstein's first success was a wooden 'fuzzy puzzle' of farm animals. Today, Melissa & Doug makes over 2,000 kinds of toys and serves as an antidote to the rise of digital toys. PLUS for our postscript "How You Built That," an update on The Cut Buddy, a stencil device that helps you cut your own hair. (Original broadcast date: December 19, 2016) See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Feb 201839min