Plaque Vulnerability and Risk Factors | JACC Deep Dive
JACC This Week21 Juli 2025

Plaque Vulnerability and Risk Factors | JACC Deep Dive

In this JACC Deep Dive, Harlan M. Krumholz, MD, SM, FACC reviews a study by Covani, et al that uses OCT imaging in over 1,500 ACS patients to show how increasing cardiovascular risk factor burden—like smoking, diabetes, and hypertension—is strongly associated with vulnerable plaque features such as thin caps, inflammation, and rupture. The findings were most pronounced in STEMI patients and reinforce the biological impact of cumulative risk. Reviewers found the core results intuitive but pushed for deeper mechanistic insights, leading to a stronger final paper with improved clarity, additional analyses, and a more nuanced understanding of how traditional risk factors shape plaque instability.

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Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

Season 2 Wrap-Up: Thank You, Reflections, and What Comes Next | JACC This Week

In this special Season 2 wrap-up of JACC This Week, Dr. Harlan Krumholz and Dr. Carolyn Lam reflect on the pilot season, the energy of ACC.26, and what they've learned from listeners along the way. Fr...

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March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

March 31, 2026: Global Cardiovascular Insights & Breakthroughs from China | JACC This Week

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March 24, 2026: Cardiometabolic Health, COVID Impact & Prevention Science | JACC This Week

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24 Mars 13min

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

March 17, 2026: Heart Failure, Chagas Research & AI in Cardiology | JACC This Week

In this episode, Dr. Carolyn Lam and Dr. Harlan Krumholz break down key studies from this week's JACC issue, including new evidence on Chagas‑related heart failure, updated diastolic function guidelin...

17 Mars 17min

March 10, 2026: Inside JACC Stats: The State of CV Health in Focus | JACC this Week

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March 3, 2026: Hypertrophic Cardiomyopathy  in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

March 3, 2026: Hypertrophic Cardiomyopathy in Focus—MAPLE-HCM Trial, Myosin Inhibitors & What Improvement Really Means | JACC This Week

In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight a mini-focus issue on hypertrophic cardiomyopathy (HCM), a field undergoing rapid transformation. The discussion ce...

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February 24, 2026: ACHD Guideline in Focus—From Survival to Stewardship | JACC This Week

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In this episode of JACC This Week, Dr. Carolyn Lam and Dr. Harlan Krumholz spotlight the 2025 Adult Congenital Heart Disease (ACHD) Guidelines and explore what they signal for the future of cardiovasc...

24 Feb 13min

JACC This Week Bonus Episode – Women's Cardiovascular Health: From Inclusion to Redesign

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