#354: The DARK Side of Bodybuilding: Eating Disorders, Cellular Health & Peptide Power—How Dylan Gemelli Rebuilt Everything

#354: The DARK Side of Bodybuilding: Eating Disorders, Cellular Health & Peptide Power—How Dylan Gemelli Rebuilt Everything

In this episode of the Longevity Podcast, I sit down with Dylan Gemelli—a name many of you may know from the bodybuilding world and the pioneering days of biohacking. Our conversation takes a very personal turn, as Dylan bravely opens up about his early struggles with body image, bulimia, and body dysmorphia, and how these challenges set the stage for his journey into fitness, nutrition, and ultimately, cellular and mitochondrial optimization.

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What we discuss:

Trigger warning: Eating disorders ... 00:03:52

Early body image struggles ... 00:08:11

Eating disorders and sports ... 00:11:11

Addiction and life rebuild ... 00:16:40

Steroids, SARMs, and peptides ... 00:18:08

Public criticism and dysmorphia ... 00:19:04

Biohacking and diet overhaul ... 00:20:42

Heart risk and labs ... 00:27:23

Individualized diet lessons ... 00:39:44

Evolving coaching philosophy ... 00:41:50

Urolithin A & methylene blue ... 00:46:28

Podcast vision and legacy ... 00:52:32

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Episode #169: Dr. Christopher Shade: Exploring Age Reversal and the Secrets of Longevity

Episode #169: Dr. Christopher Shade: Exploring Age Reversal and the Secrets of Longevity

Can you imagine a world where you're not bound by the inevitability of aging? These days it seems as though there’s a never-ending pursuit of immortality, but it’s important to question the quality of life that extended lifespans might offer. The secret to a longer, happier life may not solely lie in age-reversing technologies and biohacking techniques, but rather in our experiences and connections with the world.   I’m joined by Dr. Christopher Shade, and we’re diving into the realm of biohacking, self-care, and the prospects of reversing and embracing aging. From nutrition and detoxification to stem cells and peptides, we discuss the plethora of tools at our disposal to reverse the aging process. We also cover the practical implications of integrating one's consciousness into a machine, and why self-care and taking responsibility for our emotional health is essential.    Dr. Christopher Shade, PhD, founder and CEO of Quicksilver Scientific®, specializes in the biological, environmental, and analytical chemistry of mercury in all its forms and their interactions with sulfur compounds, particularly glutathione and its enzyme system. Dr. Shade is regularly sought out to speak as an educator on the topics of mercury, environmental toxicities, neuroinflammation, immune dysregulation, and the human detoxification system in the United States and internationally. He has helped corporate executives, professional athletes, celebrities, children with autism, patients with chronic immune disorders and more. He strives to evolve the way the medical industry delivers care, and he is perpetually broadening the way the world understands health. Thank you to our sponsors for making this episode possible: QuickSilver Scientific: Use code NAT at https://glnk.io/zvxl/biohackingnat Restoracell: Use code NAT25 at https://www.vitaliskincare.com/ LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Christopher Shade: Website: quicksilverscientific.com Instagram: @dr.christophershade, @quicksilverscientific What we discuss: (0:00:04) - Reversing and embracing aging (0:09:44) - Benefits of biohacking and self-care (0:15:34) - Detoxification and chronic infections (0:22:30) - Bio reset (0:35:07) - Functional and integrative medicine (0:45:50) - Bio age reset and detox program (0:57:05) - The power of self-love and gratitude Key Takeaways: Taking 100% responsibility for our internal emotional life means being mindful of how we choose to respond to others. We don't necessarily have to get upset when someone says something negative to us, as our emotional reactions are our own responsibility. This also extends to taking 100% responsibility for our own personal growth and life journey, and being mindful of our words and actions towards others. Bile serves as the pathway for toxins to exit the liver and enter the gastrointestinal (GI) tract. However, stress, being in a sympathetic state, and estrogen dominance can block bile flow. This can lead to activation of glutamate receptors and hinder the prioritization of regenerative processes. It is easy to fall into an inflammatory state, inhibiting positive growth and contributing to weight gain. Toxins play a role in triggering and prolonging this inflammatory state, preventing us from entering a positive, regenerative state. There are a multitude of environmental toxins that we are exposed to, as well as our own biological waste, which can accumulate if our body's processes are not functioning properly.

15 Aug 20231h 6min

Episode #168: Dr. Anurag Singh: Mitochondrial Activation and Its Impact on Muscle Performance

Episode #168: Dr. Anurag Singh: Mitochondrial Activation and Its Impact on Muscle Performance

Whether you’re a professional athlete or someone who just wants to maintain muscle mass as you get older, mitophagy is a process we should all be focusing on. Prioritizing strategies that enhance mitophagy and promote muscle health can significantly contribute to a healthier and longer life. But what exactly can we do to promote mitophagy? Luckily, my guest today is an expert in the science of mitochondrial activation, and he’s sharing insights on the supplement that you need in your longevity routine.   I’m joined by Dr. Anurag Singh, and we’re diving into the realm of mitochondrial activation and its impact on muscle performance and health. We also shed light on the role of immunity in a healthy, long life, focusing on how mitochondrial health can rev up our immune systems. Dr. Singh also shares his insights on how mitochondrial health can influence skin health and reverse sun damage, and the development of topical formulations that can improve mitochondrial health in the skin.   Dr. Anurag Singh is the Chief Medical Officer at Timeline Nutrition.    Thank you to our sponsors for making this episode possible:   Timeline is offering 10% off your first order of Mitopure. Go to timelinenutrition.com/NAT10 and use code NAT10 to get 10% off your order.   Paleovalley: Try my go-to snacks, the Paleovalley beef sticks. Head to paleovalley.com/nathalie to save 15% on your order. Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Anurag Singh: Website: https://www.timelinenutrition.com/ Instagram: @timelinenutrition   What we discuss: (0:00:00) - Mitochondrial activation and muscle performance (0:12:13) - Revving up immune health through mitochondria (0:15:24) - Mitochondrial health and immune function studies  (0:21:06) - The benefits of high-dose vitamin c  (0:26:20) - Skin aging and mitochondrial health (0:27:53) - Topical formulation and skin health  (0:33:22) - Supplement industry quality and safety   Key Takeaways: The muscle is the most metabolically active organ in our body. It both produces and consumes the most energy currency, ATP. This is because even small movements like getting up from a chair or climbing stairs require a significant amount of energy. Activating mitophagy, the process by which damaged or dysfunctional mitochondria are selectively removed, has been shown to have significant positive effects on muscle performance. By selectively eliminating these damaged components, it allows for the generation of new and healthy mitochondria, thus enhancing muscle function.  Maintaining a healthy immune system can directly impact our overall health and lifespan. Immune cells, just like muscle, brain, and heart cells, contain numerous mitochondria. These mitochondria play a crucial role in supporting the high energy demands of immune cells.

8 Aug 202353min

Episode #167: Dr. Felice Gersh: Navigating the Hormonal Pathways of Women's Health

Episode #167: Dr. Felice Gersh: Navigating the Hormonal Pathways of Women's Health

Did you know that hormones play a pivotal role in directing the course of your health throughout your lifetime? From physical growth and development to emotional well-being and reproductive health, these chemical messengers are vital for our overall well-being. Understanding how hormones function and seeking appropriate medical guidance can help us navigate through the various stages of life while maintaining hormonal balance.   Dr. Felice Gersh joins me as we take a closer look at the different types of estrogens, their individual impacts on the body, and the importance of understanding their nuances for overall health. We also discuss how reproduction is the prime directive of life and how hormones act as 'hormonal glue' to enable reproductive success. Plus, we dive into some of the benefits and complexities of Hormone Replacement Therapy (HRT), including when to start and the potential risks associated with it.   Dr. Felice Gersh is board-certified in both OB/GYN and Integrative Medicine. She is the founder and Medical Director of the Integrative Medical Group of Irvine. Always passionate about learning and education, she taught obstetrics and gynecology at Keck USC School of Medicine for 12 years as an Assistant Clinical Professor. Dr. Gersh now serves as an Affiliate Faculty Member at the Fellowship in Integrative Medicine, through the University of Arizona School of Medicine, where she lectures and regularly grades the case presentations written by the Fellowship students for their final exams. Dr. Gersh is a globally recognized expert on a wide range of female and integrative health topics.      Thank you to our sponsors for making this episode possible: Restoracell: Use code NAT25 at https://www.vitaliskincare.com/ Troscriptions: Use code NAT10 at https://troscriptions.com/ LVLUP: Use code NAT10 to save 10% off at https://lvluphealth.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Felice Gersh: Website: https://integrativemgi.com/ Instagram: @dr.felicegersh    What we discuss: (0:00:03) - The importance of women's hormones (0:16:18) - Understanding the different types of estrogens (0:20:05) - The effects of hormone therapy (0:27:25) - Exploring hormone replacement and natural alternatives (0:34:47) - The benefits of cyclical hormone therapy (0:45:23) - Benefits of vaginal estrogen and hormone replacement therapy (0:53:58) - The complexities of hormone replacement therapy (1:06:24) - Testing hormones for women   Key Takeaways: Osteoporosis is a condition where bone loss occurs gradually over time. However, in the first few years after menopause, there is a significant acceleration of bone loss. If individuals have not proactively taken measures to mitigate this rapid loss, their condition could worsen. This pattern can be applied to other organ systems as well, where starting the menopausal transition in a good state overall leads to better outcomes. It is essential to understand that the testosterone produced by the ovaries plays a crucial role in promoting overall health and well-being in women. The ovaries have the ability to produce testosterone indefinitely in a different part of the ovary, even after the eggs are depleted. This explains why removing the ovaries, even in post-menopausal years when they are no longer producing estrogen or progesterone, can negatively impact a woman's health and increase mortality.  The prime directive of life is reproduction, and humans are the only species on the planet that actively work towards controlling their reproductive fate. Unlike animals in the wild, humans have the capability to make deliberate decisions about when to have children. Setting aside the aspect of choice, it is crucial to understand that the female body is inherently optimized and designed for fertility and reproduction.

1 Aug 20231h 16min

Episode #166: Martha Carlin: Unlocking the Mysteries of the Microbiome

Episode #166: Martha Carlin: Unlocking the Mysteries of the Microbiome

Imagine a world where you could restore balance to your body, combat chronic diseases, and improve health trajectories through a deep understanding of your microbiome. That's exactly what we're exploring today with businesswoman-turned-research-scientist Martha Carlin, who embarked on this incredible journey after her husband was diagnosed with Parkinson's at a young age. Her captivating research has led to groundbreaking connections between the microbiome and the onset of chronic diseases such as Parkinson's, and she believes that restoring the microbiome could make a substantial difference in our overall health.   We're diving into the complex world of microbial peptides, toxins, and pathogens, particularly their influence on the body's immune system. We also discuss the potential links between copper, iron, and neurological diseases, and how copper's role in iron regulation could have far-reaching implications. Martha's fascinating insights also shed light on the connection between glyphosate, food contamination, and how it could be affecting our health.   Martha Carlin is a Citizen Scientist, systems thinker, wife of Parkinson’s warrior, John Carlin, and founder of The BioCollective, a microbiome company expanding the reach of science. Since John’s diagnosis in 2002, Martha began learning the science of agriculture, nutrition, environment, infectious disease, Parkinson’s pathology and much more. In 2014, when the first research was published showing a connection between the gut bacteria and the two phenotypes of Parkinson’s, Martha quit her former career as a business turnaround expert and founded The BioCollective to accelerate the discovery of the impact of gut health on all human health, including Parkinson’s.       Thank you to our sponsors for making this episode possible: Learn more and shop at biotiquest.com + use code NAT10 for a 10% off discount BiOptimizers: For Sleep Breakthrough use code BIONAT10 at checkout to save 10% at sleepbreakthrough.com/bionat Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com LVLUP: Use code NAT10 to save 10% off at https://lvluphealth.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Martha Carlin: Website: https://biotiquest.com/ Facebook: https://www.facebook.com/BiotiQuest Twitter: https://twitter.com/BiotiQuest Instagram: https://www.instagram.com/biotiquest/ What we discuss: (0:00:04) - Parkinson's and the microbiome link (0:08:59) - Sleep disruption in neurodegenerative diseases (0:13:29) - Toxins, pathogens, and the Parkinson's microbiome (0:24:35) - Copper's role in iron regulation (0:42:49) - Glyphosate contamination and organic farming (0:47:59) - Parkinson's symptoms improvement through diet (0:54:30) - Red light therapy and microbiome health (1:04:33) - Improving health and restoring balance Key Takeaways: In some ways, the process of consuming food can be seen as a way of receiving information from the food itself. When we eat, our bodies extract various nutrients and compounds from the food, which contain valuable information that gets transmitted to our system. The gut plays a crucial role in this process, serving as the interface or channel for communication between the food and our cells. Heat Shock Protein (HSP) 65 is produced by certain pathogens or microbes, and it is not beneficial to us. On the other hand, HSP 60 and Alpha-b Crystallin play important roles in maintaining our health. However, the presence of the nefarious alpha crystalline and HSP 65 confuses our body, causing it to mistakenly attack our own beneficial proteins.  Higher iron levels may increase the likelihood of hosting more pathogens, and the immune system responds by attempting to sequester the iron and prevent pathogen access. However, this defensive strategy often involves storing iron in the body's tissues, which subsequently leads to inflammation.

28 Juli 20231h 15min

Episode #165: Forrest Smith: The Healing Power of Red Light Therapy

Episode #165: Forrest Smith: The Healing Power of Red Light Therapy

If you’ve ever suffered from joint pain or inflammation, you know just how much it can take a toll on your quality of life. Whether you’re an athlete suffering from a sports-related injury or someone who’s noticed more and more aches and pains as you’ve gotten older, finding a solution to joint pain can seem almost impossible. Luckily, my guest today is here to talk about the light therapy device that ​​is a game-changer for pain management.   I’m joined by Forrest Smith, the CEO of Kineon Labs, to dive into the benefits of using light therapy to reduce joint pain. We discuss how localized inflammation has the potential to spread through the body if not addressed, and how red light can target specific reservoirs. We also talk about the balance of cartilage regrowth and degradation, and the benefits of Kineon Lab’s MOVE+ Pro.   Forrest Smith has a 20-year history of building successful startups in tech hardware. He is an entrepreneurial optimist and passionate about health, wellness, and advancing technology to help others. Forrest speaks, reads, and writes fluent Chinese and has spent his adult life building amazing products around innovative supply chains. He grew up playing competitive sports in Atlanta and regularly participates in rugby matches and trains CrossFit, which ultimately led him to develop Kineon Lab’s Move+: a modular, targeted laser therapy device for neuromuscular pain and inflammation. Thank you to our sponsors for making this episode possible: Use code NAT10 to save 10% at https://kineon.io/ Paleo Valley: Use discount code paleovalley.com/natalie LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Mitopure: Use code NAT10 for 10% your order at https://www.timelinenutrition.com/shop/nutrition Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Forrest Smith: Website:  https://kineon.io/ Instagram: @kineon_labs Facebook Group: https://www.facebook.com/groups/302581657766248   What we discuss: [00:00:50] Kineon Labs’ approach to helping people solve their joint pain  [00:04:23] The benefits of red light therapy  [00:08:34] How does red light target specific reservoirs? [00:12:37] The balance of cartilage regrowth and degradation [00:18:10] Why it’s important to address localized inflammation [00:25:39] Treating the underlying mechanisms of what's causing pain  [00:35:05] The different types of protocols the MOVE+ Pro offers [00:39:58] Who can benefit from MOVE+ Pro [00:46:05] Future products coming to Kineon Labs [00:56:31] How surgery can lead to trauma in the tissue [00:59:46] Can MOVE+ Pro be used in multiple areas during a session? Key Takeaways: Cartilage, the slow-growing but ever-evolving tissue in our bodies, plays a crucial role in supporting our joints and bones. Similar to bones, cartilage grows gradually and follows a unique process involving specialized cells called chondroblasts. These chondroblasts can be stimulated to proliferate faster through the application of infrared and red light treatment. Locally generated inflammation damages more than just the regional delivery of blood- it also damages the blood vessel tissue throughout the rest of your body, which is a main cause of long term cardiovascular disease. By addressing the localized inflammation, you're preventing it from spreading to the rest of the body. Infrared light has the ability to interact with proteins like hemoglobin, cytochrome C oxidase, and other heme proteins in the mitochondria. By targeting these proteins with infrared light, it reduces the affinity of nitric oxide for their binding sites, enabling them to access more oxygen. This interaction can potentially enhance oxygen delivery in the body.

25 Juli 20231h 10min

Episode #164: Carolina Oliveira: Healthy Skin Aging, Cellular Senescence, and OneSkin

Episode #164: Carolina Oliveira: Healthy Skin Aging, Cellular Senescence, and OneSkin

Our skin was designed to function as a barrier to protect our bodies from environmental stressors and pathogens, but unfortunately, our skin barrier is one of the main factors that is compromised as we age. Many of us are constantly looking for the next best thing to slow down and possibly even reverse these signs of skin aging, and my guest today is here to explain why focusing on products that work on the molecular level is the key to healthy aging.   I’m joined by Carolina Oliveira, the CEO and co-founder of OneSkin, to discuss everything you need to know about healthy aging in the skin. We cover cellular senescence, biological age, systemic inflammation, and the research being done at OneSkin to quantify these things. We also talk about some of the other factors that have an impact on skin health, and of course dive into the first peptide developed to reverse skin aging at the molecular level: OS-O1.   Carolina Oliveira is the CEO and co-founder of OneSkin. She holds a Ph.D. in stem cell biology and tissue engineering, is a co-inventor of 5 patents and co-author of numerous scientific publications. She relocated from Brazil to Silicon Valley in 2016 to found OneSkin, a fast-growing longevity company developing products to promote skin health by targeting aging at the molecular level. Carolina is an alumnus of IndieBio, the world's largest biotech accelerator and has been an active voice in the longevity field, pioneering age reversal skin research with OneSkin.  Thank you to our sponsors for making this episode possible: OneSkin: Use code SUPERHUMAN15 at https://www.oneskin.co/ BiOptimizers: For Sleep Breakthrough use code BIONAT10 at checkout to save 10% at sleepbreakthrough.com/bionat Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com Neurohacker Collective: https://bit.ly/QNHNat and use code NN15 Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Carolina Oliveira: Website: oneskin.co   What we discuss: [00:03:24] The skin barrier and why our skin becomes more fragile as we age [00:08:30] Does nutrition have a big impact on skin health? [00:16:05] The skin’s biological age clock [00:22:48] Does cellular senescence affect skin elasticity? [00:28:07] Ingredients to avoid when looking for skincare  [00:35:37] How long does it take to see results from OneSkin products?  [00:43:22] How OneSkin products can potentially lower systemic inflammation [00:50:09] The different concentration of OS-O1 in each product Key Takeaways: Cellular senescence is a process in which cells stop dividing after reaching their replication limit of around 50 times. These cells have accumulated various mutations that can lead to cancer if they continue to divide. Therefore, cellular senescence functions as a protective mechanism for the body. However, these senescent cells also secrete inflammatory signals that can cause neighboring cells to age faster. When it comes to choosing skincare products, it is important to pay attention to the ingredients list. Some ingredients, like parabens and fragrance, can cause irritation or harm to the skin. Parabens are preservatives that have been linked to endocrine disruption, while fragrance can cause allergic reactions or sensitivity.  Websites like EWG can be a helpful resource for checking the safety of skincare products and their ingredients.  Advanced Glycation End-products (AGEs) are naturally occurring compounds that are formed when glucose reacts with proteins in the body. The accumulation of AGEs in the skin leads to the degradation of collagen and elastin fibers, which are responsible for keeping the skin firm and elastic.

18 Juli 20231h 8min

Episode #163: Caleb Greer: The Therapeutic Benefits of Ketamine

Episode #163: Caleb Greer: The Therapeutic Benefits of Ketamine

The rise of ketamine therapy has been a hot topic in the world of medicine. For decades, ketamine has been used as an anesthetic in surgery and as a pain reliever. However, in recent years, it has gained attention as a potential treatment for depression, anxiety, PTSD, and other mental health disorders. As the use of ketamine therapy continues to grow, more and more patients are finding relief from their mental health issues and an improved overall quality of life.   I’m joined by Caleb Greer, and we’re diving into the world of ketamine therapy. We cover how exactly ketamine works and what people feel when using ketamine, plus how it can be used as an effective treatment for mental health issues. We also discuss the long-term effects of ketamine, how it can help inhibit pain, and the difference between ketamine and other well-known psychedelics.    Caleb Greer is the founder of Dasein Health. In pursuit of becoming a well-rounded practitioner, Caleb studies all facets of human physiology and applies his understanding to the realms of mental and physical health. In his short time in practice, Caleb has helped over a thousand individuals reintroduce and optimize function through his multidisciplinary approach that integrates neurology, psychology, epigenetics, nutrition, biomechanics, and medicine.   Thank you to our sponsors for making this episode possible: Mitopure: Use code NAT10 for 10% your order at https://www.timelinenutrition.com/shop/nutrition Sensate: Use code NAT at https://buy.getsensate.com Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Caleb Greer: Website: https://www.daseinhealth.org/, https://daseinhealth.substack.com/ Patreon: https://www.patreon.com/DaseinHealth Instagram: @daseinhealth What we discuss: [00:02:01] The idea that drugs can be utilized for therapeutic purposes  [00:08:47] What do people feel when using ketamine? [00:14:32] Using ketamine for chronic pain  [00:23:04] Ketamine can help people to see the fundamental sense of belonging [00:31:20] Ketamine therapy can speed up the acknowledgment of changes [00:39:04] Is ketamine addictive? [00:51:52] How to access ketamine therapy Key Takeaways: Ketamine is a type of drug that is known to be dissociative. This means that it can cause a person to feel disconnected from the outside world, as if they are in their own world. Ketamine can also cause a person to experience a highly introspective state, where they are able to reflect on their thoughts and emotions in a deeper way than usual. Ketamine is known to be anti-nociceptive, which means that it has the ability to block the signals that are responsible for registering pain in the brain. This means that ketamine can be used to effectively manage pain in patients who are experiencing acute or chronic pain. Ketamine has been found to be particularly effective in addressing emotional dysregulation, which is a common symptom of various mental health conditions. By acknowledging and addressing this symptom, ketamine therapy can help people gain a better understanding of their emotions and learn how to regulate them more effectively.

11 Juli 20231h 6min

Episode #162: Dr. Nick Bitz: Senescent Cells, Senolytics, and the Importance of Cellular Senescence

Episode #162: Dr. Nick Bitz: Senescent Cells, Senolytics, and the Importance of Cellular Senescence

Did you know that by the age of 40-50, people have anywhere between 10 to 30% senescent cells in their tissues? Senescent cells are one of the hallmarks of aging, and can disrupt physiology throughout the body. Cellular senescence is the process by which cells permanently stop dividing but do not die off. These senescent cells linger inside the body and accumulate over time, affecting the healthy function of tissues and organs as we age.   I’m joined by Dr. Nick Bitz, and we’re diving into everything you need to know about senescent cells and cellular senescence. We discuss why our bodies need some senescent cells, and some of the lifestyle changes we can make to support the body's ability to clear senescent cells. Plus, we answer the question: How young is too young to be worried about your senescent cells?    Dr. Nick Bitz is a Naturopathic Physician that specializes in Ayurvedic medicine. He is a leading voice in the natural products industry and currently serves as Senior VP of Product Development at Neurohacker Collective. His areas of expertise include nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements. Thank you to our sponsors for making this episode possible: Add Neurohacker’s Senolytic to your longevity routine by using code NATHALIE at neurohacker.com/nathalie  LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Nick Bitz: Website: https://neurohacker.com/ Instagram: https://www.instagram.com/neurohacker/ Facebook: https://www.facebook.com/neurohackercollective LinkedIn: https://www.linkedin.com/in/nick-bitz-283a03b/   What we discuss: [00:04:18] Why our bodies need some senescent cells  [00:11:34] How young is too young to be worried about your senescent cells?  [00:19:18] Lifestyle changes to support the body's ability to clear senescent cells  [00:30:43] Optimizing health throughout the entire body [00:40:53] Targeting different communities of senescent cells  [00:47:21] The importance of intermittent fasting Key Takeaways: 40 years old is the age where it is especially important to start taking steps to prevent senescent cells from accumulating in the body and causing age-related diseases, inflammation, weakened immune system, and cell damage.  Autophagy is the process by which cells break down and recycle their own components. Promoting autophagy can help reduce the formation of senescent cells, as it can help the body remove damaged cells and other debris that can accumulate and lead to cell senescence.  Senescent cells can accumulate in different tissues and organs, such as the skin, heart, and lungs, and can disrupt normal function. Therefore, it is important to address senescent cells in all tissues and organs to ensure optimal health.

4 Juli 20231h 7min

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