Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
Huberman Lab24 Juli 2025

Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

In this Huberman Lab Essentials episode, my guest is Dr. Matthew Johnson, PhD, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics. We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Timestamps 00:00:00 Matthew Johnson; Psychedelics 00:01:44 Different Classes of Psychedelics 00:04:33 Psychedelics & Altering Models 00:06:18 Sponsor: David 00:07:33 LSD, Psylocibin & Serotonin 00:09:55 Psychedelic Clinical Trials 00:13:40 Therapy, Trust, Psychedelics 00:16:47 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes 00:22:31 Sponsors: AG1 & BetterHelp 00:25:26 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience 00:28:49 Dangers of Psychedelics 00:31:11 Microdosing Psychedelics, Antidepressant 00:35:27 Head Injuries, Psychedelics, Depression 00:38:29 Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

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How Hormones Shape Sexual Orientation & Behavior | Dr. Marc Breedlove

How Hormones Shape Sexual Orientation & Behavior | Dr. Marc Breedlove

Dr. Marc Breedlove, PhD, is a professor of neuroscience at Michigan State University and an expert on how hormones shape brain development and sexual orientation. We discuss how prenatal testosterone ...

30 Mars 2h 11min

Essentials: Using Salt to Optimize Mental & Physical Performance

Essentials: Using Salt to Optimize Mental & Physical Performance

In this Huberman Lab Essentials episode, I explain how salt (sodium) affects mental and physical performance, as well as cellular health. I describe how the brain monitors sodium levels to regulate th...

26 Mars 38min

The Best Vitality & Health Protocols | Dr. Rhonda Patrick

The Best Vitality & Health Protocols | Dr. Rhonda Patrick

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease ri...

23 Mars 3h 31min

Essentials: Tools for Setting & Achieving Goals | Dr. Emily Balcetis

Essentials: Tools for Setting & Achieving Goals | Dr. Emily Balcetis

In this Huberman Lab Essentials episode, my guest is Dr. Emily Balcetis, PhD, a professor of psychology at New York University who studies how visual perception influences motivation and goal pursuit....

19 Mars 36min

Science-Based Meditation Tools to Improve Your Brain & Health | Dr. Richard Davidson

Science-Based Meditation Tools to Improve Your Brain & Health | Dr. Richard Davidson

Dr. Richard Davidson, PhD, is a professor of psychology and psychiatry at the University of Wisconsin–Madison and a pioneer in the scientific study of meditation. We discuss how meditation changes you...

16 Mars 2h 43min

Essentials: Benefits of Sauna & Deliberate Heat Exposure

Essentials: Benefits of Sauna & Deliberate Heat Exposure

In this Huberman Lab Essentials episode, I discuss the mechanisms through which deliberate heat exposure enhances both physical and mental health. I outline specific protocols for deliberate heat exp...

12 Mars 43min

Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson

Avoiding, Treating & Curing Cancer With the Immune System | Dr. Alex Marson

Dr. Alex Marson, MD, PhD, is a Senior Investigator at the Gladstone Institutes and a professor of medicine at the University of California, San Francisco. We discuss the biology of the immune system a...

9 Mars 2h 27min

Essentials: The Biology of Taste Perception & Sugar Craving | Dr. Charles Zuker

Essentials: The Biology of Taste Perception & Sugar Craving | Dr. Charles Zuker

In this Huberman Lab Essentials episode, my guest is Dr. Charles Zuker, PhD, a professor of biochemistry, molecular biophysics and neuroscience at Columbia University and an Investigator with the Howa...

5 Mars 35min

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