Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
Huberman Lab24 Juli 2025

Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

In this Huberman Lab Essentials episode, my guest is Dr. Matthew Johnson, PhD, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics. We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Timestamps 00:00:00 Matthew Johnson; Psychedelics 00:01:44 Different Classes of Psychedelics 00:04:33 Psychedelics & Altering Models 00:06:18 Sponsor: David 00:07:33 LSD, Psylocibin & Serotonin 00:09:55 Psychedelic Clinical Trials 00:13:40 Therapy, Trust, Psychedelics 00:16:47 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes 00:22:31 Sponsors: AG1 & BetterHelp 00:25:26 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience 00:28:49 Dangers of Psychedelics 00:31:11 Microdosing Psychedelics, Antidepressant 00:35:27 Head Injuries, Psychedelics, Depression 00:38:29 Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

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Essentials: Using Meditation to Focus, View Consciousness & Expand Your Mind | Dr. Sam Harris

Essentials: Using Meditation to Focus, View Consciousness & Expand Your Mind | Dr. Sam Harris

In this Huberman Lab Essentials episode, my guest is Dr. Sam Harris, PhD, a neuroscientist, bestselling author, and world-renowned meditation teacher whose work focuses on consciousness, ethics, and r...

23 Juli 0s

Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood

Accelerate Learning & Increase Cognitive Capacity | Dr. Tommy Wood

Dr. Tommy Wood, BM, BCh, PhD, is a professor of neuroscience at the University of Washington and an expert on brain health, neuroplasticity, and cognitive performance. Dr. Wood explains how to use spe...

20 Juli 2h 41min

Essentials: The Science & Treatment of Bipolar Disorder

Essentials: The Science & Treatment of Bipolar Disorder

In this Huberman Lab Essentials episode, I explain the biology, symptoms and types of bipolar disorder (sometimes called bipolar depression), a condition characterized by extreme, maladaptive shifts i...

16 Juli 35min

How to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel

How to Improve Your Memory & Cognitive Function at Any Age | Dr. Alan Castel

Dr. Alan Castel, PhD, is a professor of psychology at the University of California, Los Angeles (UCLA) and one of the world's foremost experts on human memory and cognitive aging. We discuss what scie...

13 Juli 2h 28min

Essentials: The Science & Treatment of Obsessive Compulsive Disorder (OCD)

Essentials: The Science & Treatment of Obsessive Compulsive Disorder (OCD)

In this Huberman Lab Essentials episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD) and describe the neural circuitry behind repetitive "thought-action loops," includi...

9 Juli 35min

Raising a Dog & Mastering Calm Assertive Energy | Cesar Millan

Raising a Dog & Mastering Calm Assertive Energy | Cesar Millan

Cesar Millan is a world-renowned dog behavior expert. We discuss how to adjust your energy and behavior to ensure your dog is calm and happy and always follows your lead. Cesar shares specific tools f...

6 Juli 2h 38min

Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett

Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett

In this Huberman Lab Essentials episode, my guest is Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine, and an expert in hormone optimization. We discuss scien...

2 Juli 40min

Movement Practice to Strengthen Your Mind-Body Connection | Ido Portal

Movement Practice to Strengthen Your Mind-Body Connection | Ido Portal

Ido Portal is a world-renowned movement coach who has developed specific practices anyone can use to greatly evolve their mental and physical health, and even gain clearer self-understanding. We discu...

29 Juni 3h

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