6.8.3 - Deep Dive into Drug Development IV: Other Modes Of Action; Metabolic vs. Pleiotropic Effects

6.8.3 - Deep Dive into Drug Development IV: Other Modes Of Action; Metabolic vs. Pleiotropic Effects

Send us a text This conversation is the fourth and final segment of SurfingMASH’s April discussion of drug development in memory of Stephen A. Harrison. In addition to co-hosts Jörn Schattenberg, Louise Campbell and Roger Green, panelists include hepatologist and key opinion leader Sven Francque. The discussion focuses on PPARs, genetic medicines, and other emerging drug classes while considering the idea that drug therapies can have an impact on the liver independent of their effect on...

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S6 - E1: Two Multispecialty February Conferences and Europe Prepares for Resmetirom

S6 - E1: Two Multispecialty February Conferences and Europe Prepares for Resmetirom

Send us a text 00:00:00 - Surf's Up! Season 6 Episode 1 SurfingMASH kicks off our sixth season in our new format, with three major elements to each episode. This week's Roundtable and Newsmakers segments focused on two recent conferences that took a multispecialty perspective on the range of medical and psychological issues affecting steatotic liver disease (a new concept specialty: steatology.") Our Expert this week is our co-host Jörn Schattenberg, discussing the educational and conceptual ...

21 Mars 1h 13min

S5 - E26.5 - Looking Back at #TLM2024 - Promoting Healthy Livers and Looking Ahead to 2025

S5 - E26.5 - Looking Back at #TLM2024 - Promoting Healthy Livers and Looking Ahead to 2025

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation reviews two sessions promoting healthy livers and asks panelists what they anticipate for #TLM2025. This last conversation starts with Jeff describing the session that moved him most and praising a panel that Mike co-chaired on Lifestyle Management of MASLD and MASH. Jeff spoke on this panel, and he descri...

3 Jan 15min

S5 - E26.4 - Looking Back at #TLM2024 - Patient Advocacy and Patient-Centric Trials

S5 - E26.4 - Looking Back at #TLM2024 - Patient Advocacy and Patient-Centric Trials

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation considers the role of patient advocacy in replacing biopsy in clinical trials with NITs and reviews a session on the foundational principles for patien-centric clinical trials. This conversation picks up at the end of Michelle's discussion of the FDA Corner session. Jeff starts by identifying this specific...

3 Jan 11min

S5 - E26.3 - Looking Back at #TLM2024 - FGF-21 Agents and the FDA Corner

S5 - E26.3 - Looking Back at #TLM2024 - FGF-21 Agents and the FDA Corner

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation reviews the late-breaker presentation on efimosermin, a q4w FGF-21 agent and the "FDA Corner" session. Jörn begins the discussion by highlighting a paper from the later breaker session on efimosfermin alfa, an FGF-21 agent dosed q4w. He notes that after only six doses (24 weeks), efimosfermin alfa dem...

2 Jan 13min

S5 - E26.2 - Looking Back at #TLM2024 - Patient Genotyping and MASH Clusters

S5 - E26.2 - Looking Back at #TLM2024 - Patient Genotyping and MASH Clusters

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation considers how the anticipated approval of a second MASH drug without biopsy might affect clinical trials and discusses two recent publications on patient genotyping and patient clusters. The conversation starts with Roger asking the group whether the presence of two approved MASH medications that do not re...

2 Jan 14min

S5 - E26.1 - Looking Back at #TLM2024 - Semaglutide Passes the ESSENCE Test

S5 - E26.1 - Looking Back at #TLM2024 - Semaglutide Passes the ESSENCE Test

Send us a text In this episode, Naim Alkhouri, Mike Betel, Michelle Long and Jeff McIntyre join Jörn Schattenberg and Roger Green to look back at The Liver Meeting 2024. This conversation reviews the ESSENCE trial, the Phase 3 trial demonstrating that semaglutide regresses fibrosis levels in some MASH patients. The conversation begins with each panelist sharing a word or short phrase they felt best captured their feelings about TLM2024. Next, panelists review the meeting's most conseq...

2 Jan 13min

 S5-26 - One Month Later: Looking Back at MASLD/MASH Coverage From The Liver Meeting 2024

S5-26 - One Month Later: Looking Back at MASLD/MASH Coverage From The Liver Meeting 2024

Send us a text 00:00:00 – Surf’s Up: Season 5 Episode 26 - Last month, close to 8,000 hepatology stakeholders convened in San Diego for The Liver Meeting 2024. Hepatology Key Opinion Leader Naim Alkhouri, Novo Nordisk International Vice President for Medicines Michelle Long, and patient advocates Jeff McIntyre from the Global Liver Institute and Michael Betel from the Fatty Liver Alliance join Jörn Schattenberg and Roger Green to discuss highlights. 00:03:23 - Introduction and Groundbreaker...

20 Dec 20241h 11min

S5 - E25 - Reviewing Expert Recommendations on the Use of Resmetirom

S5 - E25 - Reviewing Expert Recommendations on the Use of Resmetirom

Send us a text 00:00:00 - Surf's Up: Season 5 Episode 25 On July 20, Clinical Gastroenterology and Hepatology released the paper, Expert Panel Recommendations: Practical Clinical Applications for Initiating and Monitoring Resmetirom in Patients with MASH/NASH and Moderate to non-cirrhotic Advanced Fibrosis. Corresponding author Maru Rinella joins the Surfers to share key points from the recommendations and offer her thoughts on what lay behind them. 00:02:26 - Introduction and Groundbreaker...

9 Aug 202442min

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