#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

In this episode, Dr. Rudy Leibel, an expert in Clinical Molecular Genetics and Genomics at Columbia University, discusses his role in the remarkable scientific story of discovering leptin. He also gets into the genetics of obesity, as well as a broader discussion of the causes and effects of obesity, energy expenditure, and metabolism.

We discuss:

  • Rudy's background, interest in obesity, and trying to understand the role and impact of adipose tissue [4:15];
  • Finding the first evidence of leptin by studying obese mice [23:30];
  • Zucker rats, and the push/pull theories of obesity [34:45];
  • A breakthrough in obesity research, and closing in on leptin [45:45];
  • Understanding leptin in humans [1:03:30];
  • What Prader–Willi syndrome teaches us about body weight regulation [1:09:45];
  • Leptin and the broad condition of obesity, metabolic consequences of weight reduction, and Peter's self-experiments [1:18:00];
  • How is appetite being regulated? [1:29:45];
  • Are there epigenetic consequences of being obese? [1:37:00];
  • What makes low-carb diets so effective at obesity reduction? [1:46:15];
  • What did Rudy believe 10 years ago that he no longer believes to be true? [1:55:15];
  • Rudy's dream study of the FTO gene [1:57:15];
  • What the hell does insulin resistance actually mean? [2:08:30]; and
  • More.

Learn more at www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.

Avsnitt(435)

#349 - AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity

#349 - AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives deep into the...

19 Maj 202511min

#348 ‒ Women's sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.

#348 ‒ Women's sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Rachel Rubin is a board-certified urologist and one of the nation'...

12 Maj 20252h 13min

#347 – Peter's takeaways on mastering sleep, dealing with chronic pain, developing breakthrough cancer drugs, transforming healthcare with AI, advancing radiation therapy, and healing trauma | Quarterly Podcast Summary #5

#347 – Peter's takeaways on mastering sleep, dealing with chronic pain, developing breakthrough cancer drugs, transforming healthcare with AI, advancing radiation therapy, and healing trauma | Quarterly Podcast Summary #5

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes ...

5 Maj 202533min

#346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H.

#346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Susan Desmond-Hellmann is a physician and scientist whose remarkab...

28 Apr 20252h 5min

#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sean Mackey is a professor of pain medicine at Stanford University...

21 Apr 20252h 47min

#344 - AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies

#344 - AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives deep into nic...

14 Apr 202521min

#343 – The evolving role of radiation: advancements in cancer treatment, emerging low-dose treatments for arthritis, tendonitis, and injuries, and addressing misconceptions | Sanjay Mehta, M.D.

#343 – The evolving role of radiation: advancements in cancer treatment, emerging low-dose treatments for arthritis, tendonitis, and injuries, and addressing misconceptions | Sanjay Mehta, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Sanjay Mehta is a radiation oncologist with over 25 years of exper...

7 Apr 20252h 12min

#342 ‒ Aging well: Peter shares strategies for improving longevity with residents at a senior living center

#342 ‒ Aging well: Peter shares strategies for improving longevity with residents at a senior living center

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter joins a unique convers...

31 Mars 202543min

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