#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
The Peter Attia Drive4 Jan 2021

#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it

John Ioannidis is a physician, scientist, writer, and a Stanford University professor who studies scientific research itself, a process known as meta-research. In this episode, John discusses his staggering finding that the majority of published research is actually incorrect. Using nutritional epidemiology as the poster child for irreproducible findings, John describes at length the factors that play into these false positive results and offers numerous insights into how science can course correct. We discuss:
  • John's background, and the synergy of mathematics, science, and medicine (2:40);
  • Why most published research findings are false (10:00);
  • The bending of data to reach 'statistical significance,' and the how bias impacts results (19:30);
  • The problem of power: How over- and under-powered studies lead to false positives (26:00);
  • Contrasting nutritional epidemiology with genetics research (31:00);
  • How to improve nutritional epidemiology and get more answers on efficacy (38:45);
  • How pre-existing beliefs impact science (52:30);
  • The antidote to questionable research practices infected with bias and bad incentive structures (1:03:45);
  • The different roles of public, private, and philanthropic sectors in funding high-risk research that asks the important questions (1:12:00);
  • Case studies demonstrating the challenge of epidemiology and how even the best studies can have major flaws (1:21:30);
  • Results of John's study looking at the seroprevalence of SARS-CoV-2, and the resulting vitriol revealing the challenge of doing science in a hyper-politicized environment (1:31:00);
  • John's excitement about the future (1:47:45); and
  • More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/JohnIoannidis

Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

Connect with Peter on Facebook | Twitter | Instagram.

Det här avsnittet är hämtat från ett öppet RSS-flöde och publiceras inte av Podme. Det kan innehålla reklam.

Avsnitt(454)

#406 ‒ Migraine, cluster headache, and tension headache: symptoms, causes, prevention, and treatment | Brian Grosberg, M.D.

#406 ‒ Migraine, cluster headache, and tension headache: symptoms, causes, prevention, and treatment | Brian Grosberg, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Grosberg is a world-renowned headache specialist who joins P...

31 Aug 1h 55min

#405 ‒ AMA #88: Metabolic liver health: how to assess risk, catch dysfunction early, and prevent or reverse liver disease

#405 ‒ AMA #88: Metabolic liver health: how to assess risk, catch dysfunction early, and prevent or reverse liver disease

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter takes a deep dive i...

24 Aug 39min

#404 ‒ Mental health beyond neurotransmitters: the role of hormones in psychiatry, why symptom reduction isn't enough, and the future of psychedelic therapies | Linus Abrams, M.D.

#404 ‒ Mental health beyond neurotransmitters: the role of hormones in psychiatry, why symptom reduction isn't enough, and the future of psychedelic therapies | Linus Abrams, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter sits down with Dr. Linus Abrams, a psychiat...

17 Aug 2h 17min

#403 ‒ Peptides: separating scientific promise from marketing hype

#403 ‒ Peptides: separating scientific promise from marketing hype

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter returns to the topic of peptides, offering ...

10 Aug 53min

#402 ‒ NMR blood analysis: how heart disease risk, insulin resistance, inflammation, and mortality risk can be assessed from a single blood sample | Jim Otvos, Ph.D.

#402 ‒ NMR blood analysis: how heart disease risk, insulin resistance, inflammation, and mortality risk can be assessed from a single blood sample | Jim Otvos, Ph.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Jim Otvos is a biophysical chemist who pioneered the use of nuclea...

3 Aug 2h 25min

#401 ‒ How curiosity transforms medicine: extraordinary discoveries that changed modern healthcare

#401 ‒ How curiosity transforms medicine: extraordinary discoveries that changed modern healthcare

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode of The Drive, Peter explores how seemingly obscure...

27 Juli 1h 4min

#400 ‒ AMA #87: Environmental pollution and longevity: air pollution, noise, light, EMFs, and practical strategies to mitigate health risks

#400 ‒ AMA #87: Environmental pollution and longevity: air pollution, noise, light, EMFs, and practical strategies to mitigate health risks

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter explores the eviden...

20 Juli 19min

#399 ‒ The evolution of Alzheimer's disease and dementia care: how early detection, personalized treatment, new therapies, and a multimodal approach are changing the landscape | Gayatri Devi, M.D.

#399 ‒ The evolution of Alzheimer's disease and dementia care: how early detection, personalized treatment, new therapies, and a multimodal approach are changing the landscape | Gayatri Devi, M.D.

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Gayatri Devi is a nationally recognized neurologist specializing i...

13 Juli 1h 56min

Populärt inom Hälsa

somna-med-henrik
rss-jossan-nina
rss-bara-en-till-om-beroende-medberoende
bullfika
inga-beiga-morsor
rss-vuxna-pa-latsas
not-fanny-anymore
rss-viktmedicinpodden
angestpodden
sa-in-i-sjalen
sexnoveller-deluxe
johannes-hansen-podcast
rss-hos-psykologen
tyngre-traningssnack
sova-med-dan-horning
rss-basta-livet
halsorevolutionen
sex-pa-riktigt-med-marika-smith
rss-sjalsligt-avkladd
rss-angra-inget-3