GHAPPcast: Setting the Standard in Biomarker Validation: EDRN Example & Lessons from Liver Cancer
GHAPPcast2 Sep 2025

GHAPPcast: Setting the Standard in Biomarker Validation: EDRN Example & Lessons from Liver Cancer

Thank you to Fujifilm for your support on this podcast episode.

In this episode of the GHAPPcast, the official podcast of Gastroenterology and Hepatology Advanced Practice Providers, host Mikhail Alper, PA-C, sits down with Natalie Oliver, PA-C, a hepatology expert from Houston Methodist Hospital and Liver Specialists of Texas. Together, they explore the critical topic of biomarker validation in liver cancer, highlighting the role of the NCI Early Detection Research Network (EDRN) in setting standards for HCC surveillance. This conversation dives into why standardization, validated assays, and harmonized study designs are essential to making biomarkers reliable across different patient populations and practices. Natalie shares her firsthand experience using tools like AFP, AFP-L3, DCP (PIVKA-II), and the GALAD score to improve the accuracy of HCC detection, reduce false positives, and guide patient conversations. Real patient stories emphasize the life-saving impact of early detection and the importance of consistent surveillance, especially in high-risk groups such as those with cirrhosis, chronic hepatitis B or C, and MASLD. Whether you’re a clinician, researcher, or student, this episode provides valuable insights into how biomarker innovation and collaboration can improve outcomes in liver cancer care and transplant medicine.

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