Communicable7 Sep 2025

Communicable E35: From Ebola to COVID-19 — Graham and Kobinger on building vaccines

In this episode of Communicable, Angela Huttner and Erin McCreary invite two titans of vaccinology, Barney Graham (Atlanta, USA), former deputy director of the NIH NIAID Vaccine Research Center and architect of the mRNA vaccines against COVID-19, and Gary Kobinger (Galveston, USA), leading virologist in the development of the first effective Ebola vaccine, rVSV-ZEBOV, for a candid conversation about their direct experience building two of the most well known vaccines to date, and deploying them to the public. The episode also reviews the different vaccine platforms and addresses vaccine hesitancy, equitable access to vaccines, and global health equity.

This episode was edited by Kathryn Hostettler and peer reviewed by Eren Ozturk of Ankara University, Ankara, Türkiye.

Terms and sources

VSV, vesicular stomatitis virus
ZEBOV, Zaire Ebolavirus
rVSV-ZEBOV, recombinant vesicular stomatitis virus expressing the (Zaire) Ebolavirus glycoprotein (vaccine)
VRC, the NIH Vaccine Research Center of NIAID
Morehouse School of Medicine Satcher Global Health Equity Institute
GuardRX, https://www.guardrx.org/en/who-we-are/

References

Marzi A, et al. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain. Science 2015. DOI: 10.1126/science.aab3920
Agnandji S, Huttner A, Zinser M, et al. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe. New Engl J Med 2015. DOI: 10.1056/NEJMoa1502924
Graham BS and Corbett KS. Prototype pathogen approach for pandemic preparedness: world on fire. J Clin Invest 2020. DOI: 10.1172/JCI139601
Jackson LA, Anderson EJ, Rouphael NG, et al. An mRNA Vaccine against SARS-CoV-2 - Preliminary Report. New Engl J Med 2020. DOI: 10.1056/NEJMoa2022483

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Avsnitt(61)

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Communicable E56: Frequentist vs Bayesian for clinical trial analysis – 99% probability you’ll want to listen to this

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Communicable E55: Bonus episode – Bundibugyo ebolavirus outbreak

In this bonus episode of Communicable, hosts Anne-Grete Märtson and Angela Huttner invite Martin Grobusch (University of Amsterdam; ESCMID Emerging Infections Subcommittee) and Daniel Bausch (National...

7 Juni 57min

Communicable E54: ESCMID Global Late Breakers, part 2

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31 Maj 55min

Communicable E53: ESCMID Global Late Breakers, part 1

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17 Maj 1h