328 | Mary Roach on Replacing Parts of Our Bodies

328 | Mary Roach on Replacing Parts of Our Bodies

Like any machine, bodies occasionally break down, and it's natural to go in search of a replacement part. Ancient societies featured simple prosthetics for teeth, noses, and limbs, while modern medicine pursues more advanced ways of replacing internal organs and microbiomes. But what is striking is not just the impressive ingenuity of our attempts to replicate human anatomy, but the surprising level of difficulty involved in doing it well. I talk with author Mary Roach about the many ways in which humans have chosen to replace bits of themselves, as told in her recent book Replaceable You: Adventures in Human Anatomy.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/09/15/328-mary-roach-on-replacing-parts-of-our-bodies/

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Mary Roach received a bachelor's degree in psychology from Wesleyan University. Her books include multiple New York Times bestsellers and have appeared on numerous best-of lists. She was a guest editor in the Best American Science and Nature Writing series, and received the Rushdie Award from the Harvard Secular Society.


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216 | John Allen Paulos on Numbers, Narratives, and Numeracy

216 | John Allen Paulos on Numbers, Narratives, and Numeracy

People have a complicated relationship to mathematics. We all use it in our everyday lives, from calculating a tip at a restaurant to estimating the probability of some future event. But many people find the subject intimidating, if not off-putting. John Allen Paulos has long been working to make mathematics more approachable and encourage people to become more numerate. We talk about how people think about math, what kinds of math they should know, and the role of stories and narrative to make math come alive. Support Mindscape on Patreon.John Allen Paulos received his Ph.D. in mathematics from the University of Wisconsin, Madison. He is currently a professor of mathematics at Temple University. He s a bestselling author, and frequent contributor to publications such as ABCNews.com, the Guardian, and Scientific American. Among his awards are the Science Communication award from the American Association for the Advancement of Science and the Mathematics Communication Award from the Joint Policy Board of Mathematics. His new book is Who’s Counting? Uniting Numbers and Narratives with Stories from Pop Culture, Puzzles, Politics, and More.Web pageWikipediaAmazon author pageTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Okt 20221h 10min

215 | Barry Loewer on Physics, Counterfactuals, and the Macroworld

215 | Barry Loewer on Physics, Counterfactuals, and the Macroworld

The founders of statistical mechanics in the 19th century faced an uphill battle to convince their fellow physicists that the laws of thermodynamics could be derived from the random motions of microscopic atoms. This insight turns out to be even more important than they realized: the emergence of patterns characterizing our macroscopic world relies crucially on the increase of entropy over time. Barry Loewer has (in collaboration with David Albert) been developing a theory of the Mentaculus — the probability map of the world — that connects microscopic physics to time, causation, and other familiar features of our experience.Support Mindscape on Patreon.Barry Loewer received his Ph.D. in philosophy from Stanford University. He is currently distinguished professor of philosophy at Rutgers University. His research focuses on the foundations of physics and the metaphysics of laws and chance.Web pagePhilPeople profileGoogle Scholar publicationsWikipediaAmazon author pageSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Okt 20221h 34min

214 | Antonio Padilla on Large Numbers and the Scope of the Universe

214 | Antonio Padilla on Large Numbers and the Scope of the Universe

It’s a big universe we live in, so it comes as no surprise that big numbers are needed to describe it. There are roughly 10^22 stars in the observable universe, and about 10^88 particles altogether. But these numbers are nothing compared to some of the truly ginormous quantities that mathematicians have found to talk about, with inscrutable names like Graham’s Number and TREE(3). Could such immense numbers have any meaningful relationship with the physical world? In his recent book Fantastic Numbers and Where to Find Them, theoretical physicist Antonio Padilla explores both our actual universe and the abstract world of immense numbers, and finds surprising connections between them.Support Mindscape on Patreon.Antonio (Tony) Padilla received his Ph.D. in physics from the University of Durham. He is currently a Royal Society Research Fellow in the School of Physics and Astronomy at the University of Nottingham. He is a frequent contributor to the YouTube series Sixty Symbols and Numberphile.Web pageNottingham staff pageGoogle Scholar publicationsAmazon author pageTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Okt 20221h 15min

AMA | October 2022

AMA | October 2022

Welcome to the October 2022 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number — based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good — and sometimes group them together if they are about a similar topic. Enjoy!Support Mindscape on Patreon.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Okt 20223h 1min

213 | Timiebi Aganaba on Law and Governance in Space

213 | Timiebi Aganaba on Law and Governance in Space

With communication satellites, weather satellites, GPS, and much more, what happens in space is already important to our lives here on Earth. And the importance of space is only going to grow as we increase the presence of humans, whether in Earth orbit or beyond. So the questions of what laws govern activity in space, and how nations and institutions should practice good governance more generally, are becoming increasingly urgent. Timiebi Aganaba is an academic and space lawyer who has experience experience in a wide variety of context and countries. We talk about the current status of space law and how to guarantee good governance going forward.Support Mindscape on Patreon.Timiebi Aganaba received Ph.D. and LL.M. degrees from the Institute of Air and Space Law at McGill University. She is currently an assistant professor in the School for the Future of Innovation in Society at Arizona State University, with a courtesy appointment at the Sandra Day O’Connor College of Law. She is also an affiliate faculty with the Interplanetary Initiative and a senior global futures scientist with the Global Futures Lab at ASU. She served as Executive Director of the World Space Week Association, and currently serves on advisory boards for the UN Space Generation Advisory Council, the Board of World View Enterprises, and the SETI Institute. She was the recipient of a Space Leaders Award from the International Astronautical Federation and her doctorate received the George and Ann Robinson Award for advanced research capabilities.Web siteASU web pageSpaceTV profileWorld Space WeekSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Okt 20221h 16min

212 | Chiara Mingarelli on Searching for Black Holes with Pulsars

212 | Chiara Mingarelli on Searching for Black Holes with Pulsars

The detection of gravitational waves from inspiraling black holes by the LIGO and Virgo collaborations was rightly celebrated as a landmark achievement in physics and astronomy. But ultra-precise ground-based observatories aren’t the only way to detect gravitational waves; we can also search for their imprints on the timing of signals from pulsars scattered throughout our galaxy. Chiara Mingarelli is a member of the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) collaboration, which uses pulsar timing to study the universe using gravitational waves.Support Mindscape on Patreon.Chiara Mingarelli received her Ph.D. in physics from the University of Birmingham. She is currently an assistant professor of physics at the University of Connecticut and a research scientist at the Flatiron Institute Center for Computational Astrophysics. Her Ph.D. thesis was selected by Springer Nature as an Outstanding PhD thesis, and she was selected as a “Voice of the Future” by the Royal Astronomical Society. She regularly contributes to science communication, including Amy Poehler’s Smart Girls and the Science Channel’s “How the Universe Works."Web siteSimons Foundation web pageGoogle Scholar publicationsWikipediaTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Sep 20221h 26min

211 | Solo: Secrets of Einstein's Equation

211 | Solo: Secrets of Einstein's Equation

My little pandemic-lockdown contribution to the world was a series of videos called The Biggest Ideas in the Universe. The idea was to explain physics in a pedagogical way, concentrating on established ideas rather than speculations, with the twist that I tried to include and explain any equations that seemed useful, even though no prior mathematical knowledge was presumed. I’m in the process of writing a series of three books inspired by those videos, and the first one is coming out now: The Biggest Ideas In The Universe: Space, Time, and Motion. For this solo episode I go through one of the highlights from the book: explaining the mathematical and physical basis of Einstein’s equation of general relativity, relating mass and energy to the curvature of spacetime. Hope it works!Support Mindscape on Patreon.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Sep 20221h 51min

210 | Randall Munroe on Imagining What If...?

210 | Randall Munroe on Imagining What If...?

What’s the fastest way to get a human being around a racetrack, if we ignore all the rules of racing? How many pages would you have to read to absorb all of the government laws that apply to you? It’s hard to imagine a better person to tackle these kinds of slightly-askew questions than Randall Munroe, creator of the xkcd webcomic. He collected some answers in his book What If?, and has released a sequel, What If? 2. We dive into how one goes about choosing the right questions and answering them, and how to make it funny along the way.Support Mindscape on Patreon.Randall Munroe received a degree in physics from Christopher Newport University, before working for a while at NASA’s Langley Research Center. He is now the creator of xkcd and the author of several books. What If? and What If? 2 are based on a regular feature in which he tackles questions asked by readers.Web siteAmazon author pageExplain xkcdWikipediaTwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Sep 20221h 8min

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