Episode #220: The Ultimate Guide to Glutathione for Longevity with Dr. Nayan Patel

This episode is the second of a two-part series on Primeadine: a new healthy aging Spermidine supplement that is already getting rave reviews. Spermidine is a potent polyamine, known for inducing autophagy or cellular renewal. As we age, our bodies are getting slower and slower in the production of spermidine leaving us more reliant on exogenous sources be they food or supplementation. Supplementation with spermidine in humans has been shown to support cognition and heart health, balance hormones and improve hair growth and fullness (including eyelashes), strengthening nails. Spermidine also positively impacts five of the nine hallmarks of aging including: misfolded proteins (impaired proteostasis), epigenetic changes, mitochondrial dysfunction, stem cell dysfunction, impaired cellular communication. Amy Lamotte is a fellow biohacker and in this episode, she shares her amazing hacks and simple and effective techniques that anyone can follow. We talk about the benefits of Spermidine, its mechanisms, and how it induces autophagy. She also shares about how she hacked her autoimmune disease, treating it and reversing it herself through diet, supplementation and testing. You shouldn't miss this episode. Listen in! Meet this week's guest: Amy Lamotte is the Managing Director of Vallotte Nutrigenomics Limited in Hong Kong. She is a clinical nutritionist and researcher specializing in personalized nutrition, nutritional biochemistry, nutrigenetics, and nutrigenomics. Other areas of interest include anti-aging, circadian biology, and the microbiome. She has a Master's of Science in Human Nutrition (summa cum laude) from the University of Bridgeport and a J.D. from Yale Law School. Key Highlights: [13:38] The mechanisms of Spermidine [06:05] What is autophagy and why is it important? [19:41] The influence of Spermidine levels in different age groups [22:12] Different factors and theories in dysregulation of spermidine [25:07] Diet has a big effect on preventive healthcare [26:50] The two great powerful combo - diet and supplements [31:35] What are the best supplements to take and not to take? [34:53] There are two types in human studies: epidemiological studies and clinical trials [38:44] The human clinical study of spermidine and the after results Linkage: Oxford Healthspan (Use promo code BIONAT15 to save 15% off your order.) Connect with Amy: Instagram: @amylamotte Linkedin: https://www.linkedin.com/in/amy-valley-lamotte-501676111/ Website: https://www.amylamotte.com/ Promo code: Bionat15 for 15% off for your full order To Try Primeadine: Primeadine.com REFERENCES FROM PODCAST INTERVIEW: REVIEW ON DIETARY & GUT MICROBIOTA POLYAMINES Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019). Dietary and gut microbiota polyamines in obesity-and age-related diseases. Frontiers in nutrition, 6, 24. EPIDEMIOLOGICAL STUDIES RE SPERMIDINE/POLYAMINES Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., ... & Madeo, F. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature medicine, 22(12), 1428-1438. Kiechl, S., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., ... & Willeit, J. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American journal of clinical nutrition, 108(2), 371-380. Pucciarelli, S., Moreschini, B., Micozzi, D., De Fronzo, G. S., Carpi, F. M., Polzonetti, V., ... & Napolioni, V. (2012). Spermidine and spermine are enriched in whole blood of nona/centenarians. Rejuvenation research, 15(6), 590-595 Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020). Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. NeuroImage, 221, 117132. Soda, K., Kano, Y., & Chiba, F. (2012). Food Polyamine and Cardiovascular Disease-An Epidemiological Study. Global journal of health science, 4(6), 170. HUMAN TRIALS RE SPERMIDINE Pekar, T., Bruckner, K., Pauschenwein-Frantsich, S., Gschaider, A., Oppliger, M., Willesberger, J., ... & Jarisch, R. (2020). The positive effect of spermidine in older adults suffering from dementia. Wiener klinische Wochenschrift, 1-8. Schwarz, C., Stekovic, S., Wirth, M., Benson, G., Royer, P., Sigrist, S. J., ... & Flöel, A. (2018). Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY), 10(1), 19. Wirth, M., Benson, G., Schwarz, C., Köbe, T., Grittner, U., Schmitz, D., ... & Flöel, A. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex, 109, 181-188. IN VIVO STUDY RE MICROBIAL SPERMIDINE PRODUCTION & BONE Chevalier, C., Kieser, S., Çolakoğlu, M., Hadadi, N., Brun, J., Rigo, D., ... & Trajkovski, M. (2020). Warmth prevents bone loss through the gut microbiota. Cell metabolism, 32(4), 575- 590. POLYAMINES/SPERMIDINE IN FOOD Handa, A. K., Fatima, T., & Mattoo, A. K. (2018). Polyamines: bio-molecules with diverse functions in plant and human health and disease. Frontiers in chemistry, 6, 10. Kandasamy, S., Yoo, J., Yun, J., Kang, H. B., Seol, K. H., & Ham, J. S. (2021). Quantitative Analysis of Biogenic Amines in Different Cheese Varieties Obtained from the Korean Domestic and Retail Markets. Metabolites, 11(1), 31. Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-1584. SEX DIFFERENCES RE EXERCISE & AUTOPHAGY INDUCTION Escobar, K. A., Welch, A. M., Wells, A., Fennel, Z., Nava, R., Li, Z., ... & Mermier, C. M. (2020). Autophagy response to acute high-intensity interval training and moderate-intensity continuous training is dissimilar in skeletal muscle and peripheral blood mononuclear cells and is influenced by sex. Human Nutrition & Metabolism, 200118.

17 Mars 20211h 6min

In this episode, Dr. Misak and I talked about how bioelectric chemistry changes our bodies and how to optimize personal energy efficiency. He has developed a fascinating system to give each of his patients insight into how their body works, based on bioelectric chemistry that effectively reads the body metrics, and then conveys individual deficiencies. Let us welcome him on this podcast as he unravels the chemistry and optimization of the human body. At the end of the episode we talk about a new antiaging supplement that Dr. Misak formulated that is getting rave reviews from his patients - after 3 years of development he has launched Vi-Telometry a unique & eclectic herbal formula that supports and possibly even restores telomeres! Dr Misak generously has provided a 10% discount for listeners who want to try Vi-Telometry for themselves: BIONAT10 https://vitelometry.com/ Meet this week's guest: Darrell S.C.S. Misak, ND, RPh - Doctor of Naturopathic Medicine, Licensed Pharmacist is a father of five healthy children and the creator of VI-Telometry. After receiving his Bachelor of Science degree in Pharmacy from West Virginia University in 1992, he gained 3½ years of university hospital pharmacy experience at Duke University Medical Center. During his hospital pharmacy experience, Dr. Misak's primary focus was clinical rounding in Oncology and General Medicine. As he began to realize the pitfalls of traditional medicine and pharmacy, he started his continued search for truth in health, which directed him to naturopathic medicine. Key Highlights: 03:07 Basic principles of how the body restores itself06:11 The five phases of health 08:53 Symptoms of poor sugar regulation 10:35 Cause and effect of deficiencies 12:43 How bioelectric chemistry can read the symptoms 14:32 Dr. Misak's Youtube journey 18:21 Metrics identifying the needed nutrition 22:00 Knowing your body better 25:21 People's testimonials about Vi-Telometry Dr Misak's Longevity supplement 28:24 The ingredients in Vi-Telometry 37:00 Growing food that will nourish the body - it goes beyond adding Phosphorus, Nitrogen & Potassium to the soil 39:00 Feeding soil to create nourishing food -the difference between organic and biodynamic food Linkage: Restoration of the Human Organism through Concentration on Numbers Hyperbaric oxygen therapy VI-Telometry Carey Reams Connect with Dr Misak: Website: https://vitelometry.com/ Dr Misak: https://vitelometry.com/pages/meet-dr-misak To try the Vi-Telometry Supplement: https://vitelometry.com/ Use promo code BIONAT10 for 10% off

11 Mars 202148min

In this episode, we meet Shawn Wells, the author of The Energy Formula, his new book that covers pretty much every aspect of health optimization you can think of - from nutrition to supplementation, sleep optimization to the people you surround yourself with and, most importantly, the inner work and healing we must take on to achieve truly show up as our best selves. Shawn also shares his incredible health journey, how he came to love himself on his way to a healthy lifestyle, and the many challenges he had to overcome along the way. As a master formulator, Shawn takes us on a deep dive into choosing the right supplements that can improve health and vitality while introducing us to some little-known compounds that are sure to be game changers in metabolic health. Meet this week's guest: Shawn Wells MPH, LDN, RD, CISSN, FISSN is the world's leading nutritional biochemist and expert on Health Optimization. He has been dubbed the "World's Great Formulator" of nutritional supplements. Shawn is a popular speaker and has been featured on over 150 podcasts, in documentaries and on TV segments. He has also written for numerous magazines, blogs and websites. Key Highlights: Shawn's personal health journey and how it shaped his career choice early on. [21:39] Shawn's unique take on what Biohacking means to him [30:57 ] What's in a name - breaking down the name of Energy Formula Book [36:41 ] The After-effects of stress on our body and their different types [43:10] Resiliency in our body critical for our well being [45:29] People that are closed to you have the biggest effect on our lives and how give-and-take should manifest in every relationship [49:13 ] This is the part where we dive into the book, supplementation etc...DiHydroBerberine, L Baiba, Grains of Paradise…. Connect with Shawn Wells: Shawn Wells Shawn Wells on Instagram Buy the Book!!! https://www.energyformula.com

4 Mars 20211h 23min

Dr Siobhan Newman is a fellow of Dr William Seed's SSRP (Seed's Scientific and Research Performance) Mastermind - a growing group of physicians specializing in practicing lifestyle and regenerative medicine using, among many other things, peptides. Dr Newman spent 20 Years as a Board-certified Emergency Room Dr. until she decided it was time to help patients actually reclaim their health and vitality. She is co-founder and Chief Medical Officer of Newman MD Lifecare in Southern California. Our conversation covers the span of her philosophy of caring for her patients and how she integrates peptides, lifestyle management and bioidentical hormone therapy to help her patients reclaim their health and vitality. Meet this week's guest: Dr. Siobhan Newman is board certified in Emergency Medicine and Family Medicine, specializes in Emergency Medicine. Dr Newman has also acquired advanced certifications in Bio-Identical Hormone Therapy and Peptide Therapy - the latter through the A4M. She is affiliated with Hollywood Presbyterian Medical Center and Good Samaritan Hospital and is Co-Founder and Chief Medical Officer at Newman MD LifeCare. Key Highlights: From Emergency Room medicine to regenerative and lifestyle practice….what made it happen? Going "back to school", learning about ways to support the body, from lifestyle to nutrition, hormones and the discovery (and study) of peptides Healing the body from the inside out The importance of symptoms over (or with testing) when assessing hormone function & balance The role of and source of toxins in inflammation and disease - addressing them through detoxification and reduced exposure Where/when do peptides fit into a protocol? Hormone replacement/optimization for people in advanced years (70's and 80's) (27:00) Dr Newman's top peptides in practice… (32:00) Optimizing the immune system with peptides.. (36:00) Using peptides in cycles and in stacks….addressing cell cycles, cellular senescence, etc. Linkage: BPC 157 Thymus alpha 1 AOD 9604 Connect with Dr Siobhan Newman: admin@NewmanLifecare.com Linkedin NewMan MD Lifecare

1 Mars 202154min

In this episode, Part 2 of the Biostrap EVO series, we get the perspective of Biostrap's Chief Science Officer - Kevin Longoria on the Biostrap technology, some of the clinical studies using it and how to apply some of the metrics to your health journey. Kevin and I continue the conversation about how the Biostrap EVO could be an essential tool for Biohackers looking for clinical grade data that they can trust. We go deeper into a new metric - arterial age and elasticity and how it may turn out to be a powerful way to assess and monitor cardiovascular health. This episode has a lot of great insights! Listen in. Meet this week's guest: Kevin Longoria is an expert in the field of Clinical Physiology with an emphasis on cardiopulmonary and nervous system-based approaches to optimizing health and athletic performance. His previous role is a Chief Science Officer (CSO) for a progressive neuroscience company. He is currently a Clinical Exercise Physiologist and the Chief Science Officer at Biostrap. To buy a Biostrap: Biostrap.com To save 10% use promo code Longevity10 Key Highlights: 01:51 How Kevin found the Biostrap and ultimately became their Chief Science Officer 03:34 Biostrap is adapting through generations 05:46 What are the limitations of Biostrap? 07:58 What are the reading specifications of Biostrap? 08:28 Understanding Arterial Age 10:20 The ideal metrics for humans 12:14 The Biostrap data checking process 15:42 The most important metrics for people 23:52 How meditation reflects data 27:13 Wearable technology and Covid research 29:16 Covid intervention 33:42 Biometrics trigger indicators 40:51 Ideal sleeping pattern routine Linkage: Patrick McCown's book, The Oxygen Circadian Pattern Photoplethysmography Connect with Kevin: Website: biostrap.com Linkedin: https://www.linkedin.com/in/kevin-longoria-2b581b164/

26 Feb 202158min

In this episode, Elias Arjan and I talk about the new edition of the Biostrap, the BiostrapEVO. I've now been using Biostrap EVO for over a month and I have to say I'm pretty impressed with the quality of the data I am getting. The BiostrapEVO along with the Shoe pod and external Heart Rate Monitor together provide one of the most advanced wearable health, activity and sleep-tracking devices on the market. The Biostrap EVO enables you to get deeper insights about your body at various points in time by providing clinical-grade data. I'm really impressed with the detailed and highly accurate data readings, exercise tracking, and recovery recommendations based on exercise, exertion, sleep quality and recovery. Another great feature of Biostrap is the heart rate monitor that provides heart rate variability, blood oxygen saturation and respiratory rate monitoring. With the upcoming release of the Heart Lab - a new feature, Biostrap EVO customers will also be able to assess and track a relatively new metric: arterial age. Listen in to the episode and discover the powerful pros of Biostrap that health hackers find game-changing. This is the first of a two-part series - in part two I talk to Kevin Longoria, Chief Science Officer at Biostrap. Meet this week's guest: Elias Arjan, is the Senior Vice President at Biostrap. As part of his executive role at Biostrap, Elias oversees the marketing, communications, and sales teams and works together with the CEO to establish strategic partnerships worldwide. As a thought-leader in the field, Elias has presented at various conferences and participated in panels across medical technology and health optimization. Elias is also the Executive Director of the LA Chapter of the Biohackers Collective, a global not-for-profit dedicated to fostering community and sharing knowledge about how to unlock the code of ultimate human potential. Key Highlights: 6:24 Elias' background from science to the arts and athletics - the amazing path that led to his current position as SVP of Biostrap today 10:45 LA Magazine's recent cover story on Biohacking - an interview with Elias and a number of other prominent Biohackers in LA...setting the record straight. 13:28 Eating disorders and OCD in biohacking is it really a thing? 14:01 Managing the spectrum between growth and comfort 19:12 What is a true measurement of our health? 22:00 the Biostrap difference from other devices 26:42 Importance of HRV data - and what actually is HRV? 29:49 Obsession in data health tracking 35:03 Variation Interval between heartbeats 38:31 Wearable technology after-effects 44:36 Possible reasons in sleep latency 53:42 Specifications of medical-grade wearables 59:00 Four key biometrics 01:12:26 Arterial age vs. chronological age 01:15:49 Biostrap as a pre-screening tool... Linkage: Heart rate variability Biohackers Collective Connect with Elias Arjan: Facebook: https://www.facebook.com/eliasarjan Website: www.biostrap.com Linkedin: https://www.linkedin.com/in/eliasarjan Get your Biostrap EVO today! Use promo code LONGEVITY10 and save 10%

22 Feb 20211h 18min

In this episode, I got the privilege to speak with three powerful and badass women who are incredibly driven into working together to fix the gap in women's health through a masterful program they created called PowHer, designed uniquely for women, by these three talented women. We talk about how finding the right partners has made this huge task remarkably effortless, how amazing their inner synergies have come together, how each of their strengths complements the other. It's just so great to see women coming together and creating something that is not built out of any amount of competition. Just ease and beauty it's truly extraordinary. Listen to the episode. Meet this week's guests: Dr. Nasha Winters A global healthcare authority and best-selling author in integrative cancer care and research consulting with physicians around the world. She has educated hundreds of professionals in the clinical use of mistletoe and has created robust educational programs for both healthcare institutions and the public on incorporating vetted integrative therapies in cancer care to enhance outcomes. Dr. Nasha aims to bring integrative, bio-individual care to the women's health community and beyond. Dasha Maximov Dasha is a yoga teacher, health coach, and founder of WhealthCo. As the Director of Health Coaching for the PowHer Program, her goal is to impart to clients and other coaches the habits that are required to make long-lasting change in health happen and to bring forth the idea that health is not reductionist, but a symphony of cascading events and things in our bodies the create an environment for disease or for health. Kayla Osterhoff Former CDC Health Scientist, Researcher, and Health Optimization Medicine Practitioner formally trained across the spectrum of the health sciences. As the Director of Research and Development for the Women's Health Organization, she aims to use their pilot 12-month women's health cohort program (PowHer) as a vehicle to help bridge the gap in women's health research and build the evidence base for high quality women-centric health care. Key Highlights: How Nasha, Dasha, and Kayla came into this together Why women get left out of too many clinical studies About the PowHer program How is the program different from other programs out there? Critical things included in the program How does this amazing program work Optimizing women's health like never before How do the tests work Common misconceptions in women's health Your cycle is a superpower The program is limited to 30 women in the US and Canada this March How do people learn about the program? Program limitations such as the age range, health issues, health history, etc. Linkage: BioCurious Podcast American Board of Naturopathic Oncology World Health Organization Summit in London Whealth.co (Women's Health Community) on Mighty Networks Centers for Disease Control and Prevention Global Heart Initiative Ambien The Red Tent book Social links: Instagram: @powherprogram | @drnashawinters | @_dashofhealth | @biocurious_kayla Website: www.powherprogram.org

16 Feb 20211h 4min

Everything You Need to Know About BPC 157 and its Practical Application in Anti-Aging, Muscle Growth and Health in General Jean-Francois Tremblay is an anti-aging expert and the owner of CanLab in Montreal, Quebec and a regular guest. In this episode, we dive deep into BPC 157, an incredibly versatile peptide that seems to have a positive effect on virtually every major system in the body. There are a plethora of different aspects of human healing that BPC 157 can assist with - from gut healing to healing of wounds, muscle, ligament, bone and tendon repair. It can also help to normalize blood pressure, improve brain health, ease withdrawal from alcohol and much more. Although there is no one peptide that can do all the work on its own, BPC 157 is one of the ones that may come the closest. It's one of a few peptides that in certain conditions can deliver results almost before people make significant changes to anything else. At this time most of the published research on BPC 157 is still mostly animal studies but we are gradually seeing an increase in human research - we still have much to learn but in this episode, we spend some time exploring what we do know and have seen. Meet this week's guest: Jean-François Tremblay is a frequent guest on this podcast. He is the founder and owner of Canlab - a lab in Montreal that synthesizes high quality peptides. Jean-Francois studied Exercise Physiology, Biochemistry, and Pharmacy at UQAM. He has been researching (in theory and in practice) peptides and SARMS since the 90's and has been studying the theoretical basis of what peptides are and their practical applications in sports performance, anti-aging, and health in general. Key Highlights: 4:32 What is BPC 157? 5:57 Does BPC 157 really work? 7:18 Using BPC 157 for gastric ulcers 8:08 BPC 157's effect on growth hormone receptors 9:11 How BPC 157 supports angiogenesis 14:11 Talking about cholesterol 16:35 Applications for Crohn's disease and Ulcerative Colitis 18:09 BPC 157 for repairing ligaments 18:59 How it normalizes blood pressure, vs lowering it 24:48 Nerve regeneration 25:29 It improves alcohol intoxication 26:51 Kidney support 27:54 The stability of BPC 157 and other peptides after reconstitution 29:19 Peptides that are used in cancer research 32:46 How fast does BPC 157 break down when we ingested? 34:47 Is BPC 157 bioavailable taken sublingually? 40:33 Tricks for using BPC 157 on an empty stomach 40:55 It resists more than we would predict with the digestive tract Connect with Jean-François Tremblay: Canlabsciences.com Promo Code: Niddam10 Disclaimer: This podcast is intended for information purposes only, none of the information is to be taken or used as medical advice. Before making any changes to your lifestyle, supplementation or nutrition please consult with your medical provider.

5 Feb 202154min