Peptides for Fat Loss w/ CanLab: Setmelanotide, AOD 9604, FRAG17691, Tesamorelin, CJC 1295 NO Dac

Peptides for Fat Loss w/ CanLab: Setmelanotide, AOD 9604, FRAG17691, Tesamorelin, CJC 1295 NO Dac

In this Interview, Jean-Francois Tremblay, owner of CanLab and I dig in to one of the new darlings of the peptide world - Tesamorelin and a less known but possibly just as effective other option - Setmelanotide - an offshoot of the better known Melantonan 2. We also cover AOD 9604, FRAG 17691 and CJC1295 ...and why you probably want to avoid the version with DAC (drug affinity complex)... We start with a chat about how if you're after lasting results there's really no way to avoid optimizing your diet, moving more, optimizing sleep etc... but these peptides might just help to speed things along and ease some of the bumps along the way.

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Show Notes:

Keto Calorie

Peptides Help with Fat Loss Body Recomposition Growth Hormone unregulated by Fat Loss peptides like FRAG 17691 or AOD9604 (just one amino acid difference) help to mobilize fatty acids in the fat cell – but need to be in calorie/energy deficit for it to stay out

Consistency and sticking to your plan is the ultimate secret sauce…

Why Canlab combines Frag and AOD 9604 More about Frag and AOD….are they the same or different? AOD lacks one tyrosine…means that it lasts longer…whereas Frag uses more up front and gets metabolized faster…..

Tesamorelin…..what it does….

The skinny on Tesamorelin….it's not about Tesa it's about the growth hormone release….

Re Muscle Gains attributed to Peptides….in studies re old people it's about bringing back muscle you once had…. Hormone replacement therapy is at the foundation of reclaiming muscle mass GH good for muscle sustaining (vs growth) and tissue repair (but doesn't hold a candle to BPC and TB4)

Tesamorelin – origins – where it came from originally….very close to CJC 1295 (Mod IGRF 121 is actually CJC 1295 without dac). and other Growth Hormone Secretagogues.

The difference between Tesa and CJC not really all that great….why some people may be promoting Tesa over CJC 1295 the magic is in the dose.

Difference about with Dac and without Dac. With Dac too many peaks of growth hormone (similar to MK 677….increases risk of insulin resistance…..why is the Dac long lasting…binds to albumin in the blood ….which is problematic as there may have been relationship to blood cancer seen in certain studies….so better to use without DAC…just use multiple times a day if necessary

Post workout (3) is a good time…but pre bed(1), pre workout and first thing in the morning (2) are all better

Setmelanotide – another derivative of alpha MSH (Melanotan, melanotan 2, PT141) Basically prioritizes appetite suppression over tanning and sexual enhancement..they all create a tan just to varying degrees…. SM get appetite curbing (some sexual stim)…increases metabolic rate by about 6%, without increasing HR or BP…. On average can expect about 1 lb a week fat loss…. Many reports of people using it with good results – safe track record…..Clinical studies went for 12 months

Do not start at full dose of 1.5mg a day….start at .5 1-2 days then 1.0mg for a couple of days and then increase to full dose to avoid possible /nausea In studies – they changed nothing else….and saw results but it's likely that as people lost weight they may have started to move more etc…

At this point best method for most peptides is SubQ over oral….Intranasal may work but need to use higher dose (aka PT141 1 mg is SubQ and 2mg is IntraNasal)

Tesofensine – not a peptide acts on dopamine and AC receptors in the brain so needs to be used with great caution Please note that this video is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition.

Avsnitt(381)

#351: How to Rewire Your Gut (and Mind) For Health: Coffee, Microbiome DIVERSITY, and The Power of Belief | Dr. Vincent Pedre

#351: How to Rewire Your Gut (and Mind) For Health: Coffee, Microbiome DIVERSITY, and The Power of Belief | Dr. Vincent Pedre

Today, I'm joined by the brilliant Dr. Vincent Pedre, one of the most sought-after experts in functional medicine and an incredible advocate for what he calls "gut-centric medicine." Together, we explore how your emotions and beliefs directly impact your gut, why there is no one-size-fits-all approach to gut healing, and the practical steps you can take to support your body's natural balance. What we discuss: Dr. Pedre's personal and medical background ... 00:06:05 Mind-body connection and overcoming fear through meditation ... 00:09:16 Impact of antibiotics and gut health journey ... 00:18:06 Energy healing, boundaries, and the empath-practitioner challenge ... 00:21:05 Gut-brain connection and integrating mindset in healing ... 00:24:45 Mindset, mantras, and patient transformation ... 00:30:04 Personalizing gut protocols and addressing resistance ... 00:39:03 Tools: intuitive eating, true cravings vs. microbiome-driven urges ... 00:47:45 No one-size-fits-all: diversity and personalized gut diets ... 00:54:08 How the Gut Smart Protocol tailors recommendations ... 00:58:54 Probiotics, spore-based options, and gut support basics ... 01:02:48 Coffee as a gut health microhabit (toxins, plastics, quality) ... 01:06:33 Happy Gut Coffee: rationale, tips, and final takeaways ... 01:09:11 Our Amazing Sponsors: StemRegen - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order. Mitolux NEW Second Generation - This second-generation red and near-infrared light therapy panel hits all the marks. Two new wavelengths—810nm and 940nm—target brain performance, deep muscle recovery, and circulation. I use GAMA mode for focus, and Fireplace 2 to wind down. Get a Mitolux BTS2 Sunlamp for 10% off at https://mitolux.com/NAT10, NAT10 will be automatically applied at checkout. MitoBlue - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng. Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

11 Juli 1h 14min

#350: Nature's Longevity CODE Revealed: Exosomes, Plasma HACKS & the Real Science of Aging | With Dr. Ian White

#350: Nature's Longevity CODE Revealed: Exosomes, Plasma HACKS & the Real Science of Aging | With Dr. Ian White

In this episode, I sit down with Dr. Ian White—one of the most exciting researchers in regenerative medicine today. If you're even a little bit curious about how to hack aging or have heard the buzz about things like plasma exchanges, exosomes, or why on earth lobsters never seem to grow old, you're in for a treat. What we discuss: Expanding autologous hematopoietic stem cells and FDA challenges ... 00:08:28 Heterochronic parabiosis, plasma exchange, and aging signals ... 00:17:35 Nature's clues: Lobsters, jellyfish, and biological age reset ... 00:24:02 Entropy, epigenetics, and limiting factors in aging ... 00:27:56 Vision: Youthful healthspan, not just longer lifespan ... 00:32:43 Amniotic fluid as a source of rejuvenation ... 00:36:01 Therapeutic results: burns, ulcers, and immune modulation ... 01:03:18 Exosomes vs. stem cells: Definitions and market problems ... 01:02:31 How exosomes function and the importance of source ... 00:51:23 Ensuring safe and effective regenerative therapies ... 01:00:10 Guidance for patients interested in exosome therapy ... 01:09:42 Dr. White's research legacy and goals ... 01:14:04 Our Amazing Sponsors: Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there. NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Berberine Breakthrough - Take 15 min. before a meal and your body will push carbs and glucose into your muscles to be used as fuel instead of turning them into fat. Enjoy more stable energy without the post-meal crash. Visit bioptimizers.com/bionat and enter the code BIONAT to get 10% off your order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

8 Juli 1h 19min

#349: Jaw-Dropping Moments From The Last 6 Months: The Conversations Still Stuck in My Head With Nat Niddam (Solo)

#349: Jaw-Dropping Moments From The Last 6 Months: The Conversations Still Stuck in My Head With Nat Niddam (Solo)

Today, I've got something special for you: a solo episode where I look back at the past six months and handpick the five episodes and ideas that truly changed the game for me—and, based on your feedback, for many of you too.   Episodes from this podcast: #300: Breast Cancer Overdiagnosis, Mammogram Myths, The REAL Risks For Women And Bold NEW Alternatives With Dr. Jenn Simmons #302: If You Have Creeky or Painful Joints and BIG Dreams of Staying Active, These Nonsurgical Solutions Are The NEW Way Forward - With Dr. Jeff Gross #309: Cordycepin and Methylene Blue: Two Game-Changers For Better Energy, Focus, Sleep, and So Much More With Dr. Scott Sherr #312: Age-Defying Bone Health: Preventing Osteoporosis with Science-Backed Interventions and Reversal Techniques You Can Try TODAY With Doug Lucas #318: Lies He Taught In Medical School: The METABOLIC Secret To Reversing Chronic Disease with Dr. Robert Lufkin   What I discuss: Exosomes for regeneration: cartilage, bone, and joint repair ... 00:02:19 Exosomes vs. PRP and stem cells—key differences ... 00:05:20 Managing inflammation before regenerative treatments ... 00:06:09 Exosomes in neurology & anti-aging ... 00:07:01 Regulation, safety, and advances in exosome therapy ... 00:08:33 Mammogram controversy: risks, overdiagnosis, and dense breasts ... 00:10:00 Alternatives: QT scan benefits and radiation-free screening ... 00:15:21 Optimizing mitochondrial health—importance & methylene blue ... 00:18:28 Widespread mitochondrial dysfunction & modern disruptors ... 00:21:03 How methylene blue supports energy & cautions ... 00:23:17 Bone health: density vs. quality, collagen, and vibration plates ... 00:31:17 Mechanical input & gaps in traditional osteoporosis care ... 00:34:22 Lifestyle reversal of chronic disease ... 00:37:15 Medical system limitations & patient health agency ... 00:39:25 Fasting and metabolic health—power & nuance ... 00:48:06   Our Amazing Sponsors: Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

4 Juli 52min

#348 The Overlooked Power of Your Lymphatic System in Longevity and Recovery (Fascia Release and Deep Healing EXPLAINED) with Dr. Stephanie Canestraro

#348 The Overlooked Power of Your Lymphatic System in Longevity and Recovery (Fascia Release and Deep Healing EXPLAINED) with Dr. Stephanie Canestraro

I'm your host, Nathalie Niddam, and today I'm thrilled to bring you a truly fascinating conversation with Dr. Stephanie Canestraro—a chiropractor, functional medicine practitioner, and someone with an incredible personal story about overcoming chronic illness. Dr. Canestraro works with elite athletes, including NHL players, but her expertise comes from her own journey through mysterious health challenges that eventually led her to discover the vital role of the lymphatic system. What we discuss: Dr. Canestraro's personal health journey and lymphatic issues ... 00:07:58 Explanation of the lymphatic system ... 00:10:33 Superficial vs. deep lymphatics and fascia's role ... 00:15:20 Personal stories of lymphatic stagnation and deep lymph solutions ... 00:17:03 Why movement isn't always enough for lymph flow ... 00:2447 Modern challenges: EMFs, toxins, fascia, and liver ... 00:25:00 Lymph, anxiety, and the vagus nerve ... 00:35:40 Tools and approaches for lymph support ... 00:39:22 Body-wide impact of fascia ... 00:43:47 Frequency medicine and resilience strategies ... 00:51:16 Our Amazing Sponsors: Bio-Shield by Young Goose - It's a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there. OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

1 Juli 1h 3min

#347: Left vs Right Brain: The NEW Science Behind ADHD, OCD & Childhood Development With Dr. Robert Melillo

#347: Left vs Right Brain: The NEW Science Behind ADHD, OCD & Childhood Development With Dr. Robert Melillo

In this episode, I'm thrilled to sit down with Dr. Robert Melillo, a clinical neuroscientist with nearly 40 years of experience decoding the mysteries of the brain and how our modern lifestyle—and especially technology—are changing it. If you've ever worried about what all that screen time means for your kids' developing brains (or your own), this conversation is going to give you a whole new perspective. What we discuss: Left/right brain imbalance and modern tech's impact ... 00:12:31 Gut health, peptides, and foundational health tips ... 00:05:37 Dr. Melillo's journey, research, and clinical experience ... 00:08:04 Technology's rapid evolution vs. brain adaptation ... 00:12:31 Making brain health more accessible ... 00:15:39 Biohacking brain interventions: risks and basics ... 00:17:34 ADHD, OCD, and the connectivity problem ... 00:20:14 How brain imbalances manifest and can be changed ... 00:23:45 Root causes: movement, milestones, and environment ... 00:39:09 Functional treatment: targeted, practical steps ... 00:47:25 Technology, lifestyle, and the left-brain epidemic ... 00:55:50 Correcting imbalances at any age ... 01:06:02 Dr. Melillo's resources and how to learn more ... 01:14:38 Our Amazing Sponsors: CAROL Bike: With its cutting-edge, science-backed method, CAROL Bike can boost your VO2max by 12% in just 8 weeks—essentially rewinding your fitness clock by a decade. The folks at CAROL Bike are offering a 100-day FREE trial! Visit http://carolbike.pxf.io/Nat or use code NAT100 for a free 100-day trial. Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off. Berkeley Life: Nitric oxide is key for blood flow, energy, brain clarity, and even healthy blood pressure. When you subscribe at BerkeleyLife.com/NAT, you'll get a free tube of 50 nitric oxide test strips with your first delivery, so you can track how your body responds. Visit BerkeleyLife.com/NAT and click "Subscribe" to get started. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

27 Juni 1h 16min

#346: How Wearables, Biological Age Tests, And AI Are Shaping the Future Of Longevity With David Korsunsky

#346: How Wearables, Biological Age Tests, And AI Are Shaping the Future Of Longevity With David Korsunsky

Today I'm joined by my friend and fellow biohacker, Dave Korsunsky, founder of Heads Up Health. In this episode, we take you on a journey through the evolution of biohacking—from the early days when continuous glucose monitors were a novelty and cryotherapy sounded like science fiction, all the way to the sophisticated, data-driven tools we have at our fingertips today. What we discuss: Dave's journey: Heads Up Health and the rise of health data ... 00:08:18 Making sense of health metrics: Knowing if protocols work ... 00:10:06 GLP-1s: muscle loss risks, proper technique, and hydration ... 00:16:18 Clinical stories: HRV, autoimmune disease, and diabetes management ... 00:25:57 The foundational power of sleep, hydration, and micro-experiments ... 00:34:14 Core metrics: HRV, blood sugar, sleep, and their significance ... 00:40:46 The promise and impact of new longevity diagnostics ... 00:50:42 No-equipment longevity tests: grip, hang, balance, sit-to-stand ... 01:00:31 Aggregate your data and run micro-experiments ... 01:05:25 Our Amazing Sponsors: Bio-Shield by Young Goose - It's a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there. OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

24 Juni 1h 10min

#345: The IMMUNITY Gamechanger | Thymosin alpha-1 Peptide (Cancer, Aging & Autoimmune) with Nat Niddam

#345: The IMMUNITY Gamechanger | Thymosin alpha-1 Peptide (Cancer, Aging & Autoimmune) with Nat Niddam

Welcome back to the Longevity Podcast! I'm your host, Nathalie Niddam—a nutritionist, human potential and epigenetic coach, and devoted biohacker. Today, I'm tackling one of your most-requested topics: Thymosin Alpha 1, a peptide that keeps lighting up conversations in my communities. Resources from the episode: Thymosin alpha 1: A comprehensive review of the literature What we discuss: Overview of Thymosin alpha-1 ... 00:02:16 Medical uses, orphan drug status, and immune effects ... 00:03:53 Contraindications and vaccine adjuvant potential ... 00:05:01 Benefits in sepsis, infections, and elderly ... 00:07:40 Mechanisms of action and immune modulation ... 00:08:31 Antimicrobial properties and hospital study highlights ... 00:09:13 Support in aging, cancer, chemo, and mold toxicity ... 00:09:53 Cautions for autoimmune and sensitive individuals ... 00:13:04 Potential cancer therapy support and anti-inflammatory effects ... 00:14:48 Wound healing, safety, and administration ... 00:20:23 Risks, final cautions, and practitioner advice ... 00:23:15 App resource, newsletter, and wrap-up ... 00:25:24 Our Amazing Sponsors: Masszymes by BiOptimizers - is the most complete, most potent digestive enzyme with over 102% MORE PROTEASE than the nearest competitor. That's crucial, because protein is the most complex macronutrient to break down. Try MassZymes at bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

20 Juni 27min

#344: Mindset Over Mortality: Top Breakthroughs for EXTREME Longevity (And How to Think Like an Immortal) with James Strole

#344: Mindset Over Mortality: Top Breakthroughs for EXTREME Longevity (And How to Think Like an Immortal) with James Strole

Welcome back to the Longevity Podcast! In this episode, I have the pleasure of sitting down with James Strole, a beacon in the radical longevity space and the visionary founder behind People Unlimited and RAADfest. James shares the personal journey that led him into the world of life extension—shaped by a spiritually open-minded mother, a pivotal loss, and a lifelong desire to challenge the idea that aging is inevitable. Get 10% off your tickets to RAADfest using code: "niddam" What we discuss: James Strole's personal journey to radical longevity ... 00:04:00 Spiritual roots and early inspiration ... 00:10:00 Transition from spiritual to scientific approaches ... 00:13:00 Launching RAADfest and the shift toward hard science ... 00:16:00 Evolution of the longevity movement over the decade ... 00:21:00 Access to longevity innovations and RAAD Clinics ... 00:22:00 Most exciting developments: gene therapy and age reversal ... 00:24:00 Daily longevity pillars: diet, movement, mindset ... 00:26:00 Mindset and embracing the possibility of immortality ... 00:35:00 Overcoming skepticism and "against nature" arguments ... 00:41:00 Societal implications of extreme longevity ... 00:44:00 Are we at the tipping point? The "era of immortality" ... 00:47:00 Advice for newcomers: join the conversation and community ... 00:50:00 Our Amazing Sponsors: NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase. Mitoblue by Wizard Sciences - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase. Mimio: A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you're eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

17 Juni 56min

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