Spermidine – The Powerful AntiAging compound you've never heard of but is about to take the world by storm

Spermidine – The Powerful AntiAging compound you've never heard of but is about to take the world by storm

Primeadine
Spermidine – The Powerful AntiAging compound you've never heard of but that is about to take
the world by storm. In this episode I sit down with Leslie Kenny the CEO and Founder of
OxFord Healthspan – a company founded for the purpose of bringing powerful healthy/anti
aging compounds to market. Today we deep dive into their first entry which is rooted in
ancient knowledge and yet relatively new to the modern world. Consider that this compound
hits at least 5 of the 9 hallmarks of aging….even better, new research seems to point to its
ability to improve immune response in elderly adults by helping certain areas of the immune
system to reboot and rejuvenate!! Oxford Span is committed to making this
supplement available to as many people as possible – for the month of December you can
benefit from introductory pricing PLUS an additional 15% discount (BIONAT15 promo code). If
you are this after December 2020 the discount code will still work!!
Note that this supplement will produce most noticeable results in the 50+ crowd who are
already seeing a decline in endogenous spermidine production and is not appropriate for
people with celiac disease or severe wheat allergies – we talk about all this and more in the
episode….enjoy!!
6:08
Leslie's story – from autoimmune disease & infertility to how she first came across spermidine
7:22
The link between ancient Japanese scrolls on longevity and sexual intimacy and spermidine
11:05
Compounds that target the 9 hallmarks of aging and the 5 specifically targeted by Spermidine
13:30
Dietary sources and the reason why supplement companies are having to extract spermidine
from wheat instead of Natto
15:30
Natto – possibly the best and most economical source of spermidine
17:33
Who should NOT use the current Spermidine supplements (including Primeadine) and why
18:02
Amount of gluten per serving vs a slice of
19:54
Why the 50+ crowd is likely to experience the best visible results from Primeadine
20:55

Endogenous and exogenous sources of spermidine
22:57
The physical signs that your spermidine production is declining
28:20
Short, medium and long term benefits
36:05
Maximum dose as determined by regulatory bodies
38:49
Getting back to the ancient Daoist Scrolls – the aging male's advantage over women

45:29
Best time of day to take Primeadine
50:27
DO NOT mix with hot foods or beverages
52:25
Introductory pricing in place until December 31, 2020
15% discount code in place for December and the new year: BIONAT15
Website:
Primeadine.com or OxfordHealthSpan.com

Just a few of the growing list of studies assessing Spermidine's possible benefits for human
and longevity
Studies/References
Effect on Hormones, Fertility in men and women
The regulatory effect of biogenic polyamines spermine and spermidine in men and women. Open
Journal of Endocrine and Metabolic Diseases, 9(03), 35
Spermidine Intake and Longevity in humans
Higher spermidine intake is linked to lower mortality: a prospective population-based study. The
American journal of clinical nutrition, 108(2), 371-380
The autophagy enhancer spermidine reverses arterial aging in aged mice. Mechanisms of ageing
and development, 134(7-8), 314-320.

Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary
foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-
1584
Ramot, Y., Tiede, S., Bíró, T., Bakar, M. H. A., Sugawara, K., Philpott, M. P., ... & Paus, R. (2011).
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell
functions. PLoS One, 6(7), e22564
Rinaldi, F., Marzani, B., Pinto, D., & Ramot, Y. (2017). A spermidine-based nutritional supplement
prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-
blind study. Dermatology Practical & Conceptual, 7(4), 17.
Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020).
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
NeuroImage, 221, 117132
Dietary polyamine intake and colorectal cancer risk in postmenopausal women. The American
journal of clinical nutrition, 102(2), 411-419

And finally an article on new findings of the effects of Spermidine on immune function is elderly
humans:
https://www.longevity.technology/autophagy-in-t-cells-maintained-by-
spermidine/?utm_source=ZohoCampaigns

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Avsnitt(382)

#304: UnMASKING GMO Dangers: The Science Monsanto Wants to Hide | Why You Should Eat Organic Whenever Possible With Jeffrey Smith

#304: UnMASKING GMO Dangers: The Science Monsanto Wants to Hide | Why You Should Eat Organic Whenever Possible With Jeffrey Smith

Today we're lifting the lid on the food industry's best-kept secrets with Jeffrey Smith. Ever wonder why gut issues, anxiety, or even insomnia are on the rise? It turns out, that GMOs and glyphosate—the chemical found in everything from cereal to wine—might have something to do with it. Jeffrey Smith is the Founder & Executive Director of the Institute for Responsible Technology, a Best Selling Author Seeds Of Deception, and a Filmmaker. He reveals the jaw-dropping results of a study where thousands of people saw improvements in 28 conditions after switching to organic. Stick around to learn why glyphosate has been called a "Darth Vader chemical" and why your pantry might be plotting against you. Resources: Glyphosate Report Non-GMO Shopping Guide…And When You Dine Out What I Discuss: NeuralRx Advertisement ... 00:01:59 Discussion on GMOs and glyphosate ... 00:06:17 The rise of certain diseases and their correlation with GMOs and glyphosate ... 00:26:43 BT toxin explanation and its risks ... 00:43:22 Impact of glyphosate on gut health and mineral absorption ... 00:53:30 Second advertisement: Youth Daily by Young Goose ... 00:49:18 Healing prospects with an organic diet ... 00:56:17 Dangers of gene editing (GMO 2.0) ... 01:03:32 Urgent need for regulatory action and support for IRT ... 01:16:01 Sponsors: Wizard Sciences (Neural Rx) - Neural Rx isn't just about a quick boost. It's designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com. Young Goose (Youth Daily) - Youth Daily activates your skin's anti-aging genes, shields against environmental nasties by day and tackles signs of aging by night. Visit Younggoose.com and use code NAT20 on your first order, or, if you're an existing customer 5NAT will reward you with an ongoing discount. SiPhox - The only comprehensive at-home blood testing solution that lets you check up to 50 biomarkers from your very own home. No travel, no appointments, just a few drops of blood on a card and you're set. Visit SiPhoxhealth.com/nat and you get 20 % off your first order using code NAT. Nat's links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

28 Jan 1h 21min

#303: The Fasting PLAYBOOK: Nathalie Niddam Reveals Top Strategies for Health & Longevity

#303: The Fasting PLAYBOOK: Nathalie Niddam Reveals Top Strategies for Health & Longevity

In this episode, I discuss the fascinating and multi-faceted practice of fasting. Today I uncover the various types of fasting—from intermittent fasting and water fasting to the more intensive dry fasting and the innovative Fasting Mimicking Diet. *More about the Fasting Mimicking Kit at prolonlife.com/Nat for 20% off (applied at checkout). If you're in Canada you can just go to Prolonfast.ca and use code NAT20 to save. What I Discuss: Types of Fasting Explained ... 01:15 Intermittent Fasting and Eating Windows ... 02:45 Skipping Breakfast vs. Skipping Dinner ... 04:10 Different Intermittent Fasting Schedules (16/8, 18/6, 20/4) ... 06:05 Benefits of Longer Fast Durations ... 09:30 Water Fasting and Its Effects ... 10:45 Dry Fasting: Risks and Rewards ... 12:20 Alternate Day Fasting Overview ... 14:50 Protein Sparing Modified Fasts ... 17:15 Introduction to Bone Broth Fasting ... 19:00 Fasting Mimicking Diet Explained ... 21:40 Significance of Nutrient Density and Sleep ... 24:25 Enhancing Fasting with Peptides, Bioregulators, and GLP1s ... 26:10 Consulting Medical Providers Before Fasting ... 28:50 Made Possible By Our Amazing Sponsor: BiOptimizers: It's the only full-spectrum magnesium supplement with 7 unique forms of magnesium that your body can actually use and absorb. Go to bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

24 Jan 34min

#302: If You Have Creeky or Painful Joints and BIG Dreams of Staying Active, These Nonsurgical Solutions Are The NEW Way Forward - With Dr. Jeff Gross

#302: If You Have Creeky or Painful Joints and BIG Dreams of Staying Active, These Nonsurgical Solutions Are The NEW Way Forward - With Dr. Jeff Gross

In this episode, I'm joined by the incredible Dr. Jeff Gross from ReCELLebrate, a top neurosurgeon specializing in non-surgical regenerative medicine. Dr. Gross is here to debunk some long-standing myths, most notably the belief that cartilage can't regrow. What We Discuss: Introduction to regenerative medicine and stem cells ... 00:50 Stem cell differentiation and their potential ... 03:45 Patient preparation before therapies ... 06:20 Exosomes and their therapeutic benefits ... 09:05 Applications in joint and sports injuries ... 12:30 Treating osteoarthritis and cartilage regeneration ... 16:10 Bone edge vs. joint injections for osteoarthritis ... 19:15 Legalities and misconceptions about stem cell therapies ... 28:30 Safety with stem cell treatments ... 31:45 PRP, adipose products, and amniotic fluid in therapies ... 34:15 Dr. Gross's professional journey in regenerative medicine ... 37:35 Dr. Gross's contact information for consultations ... 42:20 Final thoughts and future advancements ... 45:00 Made Possible By Our Amazing Sponsor: Puori - Ready to ditch the questionable protein powders? Visit Puori.com/NAT and use my code NAT to get 20% off your first order. BEAM Minerals - Their Liquid Formula delivers the perfect mix of all these sleep supporting minerals. Visit beamminerals.com and use code NAT20 to get 20% off your order. Young Goose - Get 10% off your first order with code NAT10 and this link. And save on future orders with code 5NAT using this link. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

21 Jan 1h 15min

#301: The 5-Day Reset - How To Get All The Benefits Of Fasting Without Feeling Hungry With Renee Fitton

#301: The 5-Day Reset - How To Get All The Benefits Of Fasting Without Feeling Hungry With Renee Fitton

In this episode, Renee Fitton from Prolon Life joins me in a discussion about how to gain all the benefits of fasting without feeling hungry and giving up! Learn more about Renee Fitton and her Fasting Mimicking Kit at prolonlife.com/Nat, where podcast listeners get 20% off at checkout! In Canada? Visit Prolonfast.ca and use code NAT20 to save. What We Discuss: Nathalie's new health initiative announcement ... 00:45 Encouragement to start fasting anytime ... 02:00 Invitation to join the group fast, March 2nd ... 05:00 Caffeinated beverages and fasting ... 07:15 Contents of ProLon five-day fast ... 08:45 L drink benefits and tips ... 09:30 Fasting recommendations ... 10:15 Muscle-sparing properties of FMD ... 12:30 Dr. Longo's research findings ... 13:15 Recommendation to start with three FMD cycles ... 14:00 FMD's benefits in oncology ... 14:45 Combining GLP-1s with FMD ... 20:00 Intermittent fasting and circadian rhythms ... 21:45 Nat's experience with ketosis ... 32:15 Bio-individuality in fasting responses ... 33:00 Safety of fasting mimicking diets ... 35:15 Made Possible By Our Amazing Sponsors: Mitopure from Timeline: Improve your cellular health by taking Mitopure in its simplest form with two vegan softgels daily for the recommended dose of Urolithin A (500mg of Mitopure). Visit timeline.com/nat10 for 10% off. SOLTEC: Struggling with restless nights and daily stress? Introducing the Soltec System—a revolutionary solution designed to transform the way you sleep and manage stress. Visit www.soltechealth.com for $100 off your purchase using code LONGEVITY. Experience the difference for yourself with a 60-day risk free trial. LVLUP: The secret to CREvolution? It's all about GAA. This powerful compound helps you get more creatine into your cells faster than traditional creatine. Ready to crush your next workout? Head to lvluphealth.com and use the code NAT for 15% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

17 Jan 1h 23min

#300: Breast Cancer Overdiagnosis, Mammogram Myths, The REAL Risks For Women And Bold NEW Alternatives With Dr. Jenn Simmons

#300: Breast Cancer Overdiagnosis, Mammogram Myths, The REAL Risks For Women And Bold NEW Alternatives With Dr. Jenn Simmons

Today, we dive into a thought-provoking discussion with Dr. Jennifer Simmons, a breast cancer surgeon turned functional medicine oncologist, who is redefining breast cancer diagnosis, treatment, and screening. Use Jenn's code: Drjenn20 for 20% of the Auria test. What We Discuss: Critique of Mammograms and Below-Average Efficacy ... 03:15 Canadian Breast Cancer Screening Trial Findings ... 06:50 Concerns with Overdiagnosis in Mammograms ... 08:25 Consequences of Unnecessary Breast Cancer Treatments ... 11:40 Absence of Predictive Tests for Cancer Aggressiveness ... 15:10 Debunking the Myth of Early Detection's Efficacy ... 18:00 Dense Breast Tissue and Mammogram Limitations ... 21:30 Risks Associated with Mammogram Radiation ... 24:10 Importance of Lymphatic System Health ... 29:00 Alternative Approaches to Monitoring Breast Health ... 32:20 Holistic Benefits of Rebounding, Dry Skin Brushing ... 35:45 Criticism of Restrictive Bras and Advice on Usage ... 38:10 Bioidentical Hormone Replacement Therapy (HRT) Insights ... 41:20 Misconceptions About Estrogen and Breast Cancer ... 45:05 Introduction to the Mitolux Device ... 51:50 Dietary and Physical Recommendations for Optimal Health ... 54:20 History and Long-term Impact of Breast Health ... 1:09:05 Pharmaceutical Dependencies and Lifestyle Impact ... 1:12:20 Arguments Against Over-treatment of DCIS ... 1:15:30 Innovative Breast Cancer Screening Tests: AURIA and QT Scan ... 1:18:50 Challenges with Current Breast Cancer Treatments ... 1:22:10 Ethical Considerations in Breast Cancer Treatment ... 1:25:45 Made Possible By Our Amazing Sponsor: SiPhox - SiPhox Health offers at-home blood testing solutions, providing custom supplements based on your personalized blood work. Visit http://SiPhoxhealth.com/nat and use code LONGEVITY to save on your test. Manukora - Looking to boost your immunity and gut health with nature's finest? Manukora Honey, sourced from New Zealand, brings you high-quality honey rich in health benefits. Visit this link http://manukora.pxf.io/kO0rJN to enjoy a special discount with the code LONGEVITY. Wizard Sciences - Ready to upgrade your brain game? Unlock your cognitive potential with Neural Rx. Use code NAT15 at checkout to get 15% off your purchase. Don't wait—start the year with a sharper, more focused mind. Visit Wizardsciences.com Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

14 Jan 1h 33min

#299: 2025 Health Breakthroughs - New GLP-1 Topics, Home Testing Innovations, and Cancer Detection with Nathalie Niddam

#299: 2025 Health Breakthroughs - New GLP-1 Topics, Home Testing Innovations, and Cancer Detection with Nathalie Niddam

In today's episode, I reveal the top health trends of 2025 that you can't afford to miss. What We Discuss: 2025 Trends in Health ... 01:15 GLP1s: Managing body composition with emerging variations ... 01:30 Importance of lifestyle factors such as diet and exercise alongside GLP1s ... 03:45 Home Testing Innovations ... 05:05 Theriom's Aristotle Test and upcoming microbiome test ... 05:25 MI Screen: Non-invasive mitochondrial function test ... 07:40 True Diagnostic: The Harmony Test for aging ... 09:00 Syphox: Comprehensive blood analysis innovation ... 10:45 Vaitrakt: Affordable gut microbiome test ... 11:35 Prodrome Science Test: Practitioner guided health insights ... 13:20 Early Cancer Detection Advances ... 15:00 Auria Test: Tear-based breast cancer detection ... 16:50 QT Scan: Imaging dense breasts non-invasively ... 18:35 Cardiovision Care: Predictive cardiovascular disease test ... 20:10 Emerging Technologies in Peptides and Bioregulators ... 21:45 Enhanced bioavailability through skin delivery ... 22:00 Addressing past traumas and experiences for holistic health ... 27:25 Closing Remarks and Teasers for Future Episodes ... 31:30 Made Possible By Our Amazing Sponsor: Mitopure from Timeline: Improve your cellular health by taking Mitopure in its simplest form with two vegan softgels daily for the recommended dose of Urolithin A (500mg of Mitopure). Visit timeline.com/nat10 for 10% off. That's timeline.com/nat10. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

10 Jan 33min

#298: Aging Well with Jean Fallacara: Simple Habits, Tech Hacks, and Longevity Tips

#298: Aging Well with Jean Fallacara: Simple Habits, Tech Hacks, and Longevity Tips

Today's guest, Jean Fallacara, is part scientist, part philosopher, and 100% here to help us rethink mornings, aging, and what it means to truly live well. What We Discuss: Biohacking challenges: optimizing versus expensive elite pursuit ... 09:26 Lifestyle shift is about sustainable, basic habits ... 13:56 Embrace natural lifestyle over modern "biohacking" ... 17:17 Calm mornings improved her busy, chaotic life ... 24:51 Morning meditation, mindfulness, present focus, no projections ... 28:39 Be the pilot of your own life ... 35:09 Age-defying calisthenics through mind-body connection ... 39:56 Gut health impacts resolutions; probiotics enhance success ... 45:56 Adjusting age impacts health, but basics remain ... 54:37 Fasting activates autophagy, aiding natural fat loss ... 59:08 Fasting weekly now, lost weight too fast ... 01:01:41 Prioritizing sleep improves well-being despite noise ... 01:06:45 Challenged, not sore; testing improved suit technology ... 01:12:03 AI impacts research, urges responsibility for future ... 01:20:05 AI-powered platform offers personalized supplement recommendations ... 01:22:44 Made Possible By Our Amazing Sponsors: Zona Health - A small, handheld device that you squeeze using the science of isometric exercise. In just a few minutes a day, it can naturally boost blood flow, reduce stress, and lower your blood pressure. Visit zona.com, and use code NAT24 to save $100 on your Zona Plus. Puori - Ready to ditch the questionable protein powders? Visit Puori.com/NAT and use my code NAT to get 20% off your first order. Or, if you want to go big and get nearly a third off with a subscription, you can do that too. Head to Puori.com/NAT and use promo code NAT at checkout. Just Thrive - The only probiotic guaranteed to arrive 100% alive where you need it most. Visit JustThriveHealth.com and use code NAT20 for 20% off your first 90 day bottle Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

7 Jan 1h 24min

Episode #297: You Want The Formula For Long-term Success with GLP-1's (aka Ozempic)? It's All Here In This, Our Most Popular, Episode of 2024 with Gus Vickery

Episode #297: You Want The Formula For Long-term Success with GLP-1's (aka Ozempic)? It's All Here In This, Our Most Popular, Episode of 2024 with Gus Vickery

Are you tired of yo-yo dieting and struggling to achieve lasting weight loss? Have you heard about the buzz surrounding GLP-1 agonist medications like semaglutide and tirzepatide but aren't sure how to effectively incorporate them into your journey? In today's episode, Dr. Gus Vickery and I discuss the effective use of GLP-1 agonist medications like semaglutide and tirzepatide for sustainable weight loss. He emphasizes the need for a mindset shift, viewing these drugs as powerful tools to catalyze positive changes rather than easy fixes or crutches. Dr. Vickery explains that these medications provide leverage to implement foundational healthy habits and that the key to success lies in focusing on nutrient sufficiency, not just calorie restriction. We also discuss concerns surrounding GLP-1 medications, such as the potential for muscle loss and the risk of regaining weight after discontinuing the drugs. He shares strategies to mitigate these issues, including resistance training, adequate protein intake, and gradual dose reduction when nearing one's goal weight. Dr. Gus Vickery is an author, speaker, and the founder and directing physician of Authentic Health in Asheville, North Carolina. He established his practice with a commitment to delivering holistic, compassionate, and evidence-based care. Thank you to our sponsors for making this episode possible: BiOptimizers: BiOptimizers: Go to bioptimizers.com/bionat and enter the coupon code BIONAT to get 10% off your order. What We Discuss: 04:00 Understanding the Power of Peptides 07:45 The Underlying Benefits of Peptides 12:59 Addressing Concerns about Side Effects 29:06 The Right Way to Use Peptides 30:06 Hormone Therapy and Peptides 34:12 Nutrient Sufficiency and Protein 41:17 The Impact of Fasting and Gut Health 45:33 Addressing Microbiome Balance 58:56 The Pace of Fat Loss and Patience 59:42 Pushing Through Plateaus and Delicate Nervous System 01:07:13 Managing Hormetic Stress and Resting the Nervous System 01:09:00 Choosing Carbs or Fats and Individualization Key Takeaways: Peptides can be a powerful tool for improving body composition and metabolic health. It is important to understand the proper use of peptides and not rely on them as a quick fix or easy way out. Peptides have a range of benefits, including improving insulin sensitivity and reducing fatty liver disease. Concerns about side effects and risks should be weighed against the potential benefits and individual circumstances Find more from Dr. Gus Vickery: Website: https://drgusvickery.com/ Authentic Health Book: https://drgusvickery.com/book/ Instagram: @drgusvickerymd Youtube: The Family Doctor Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat's Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: www.NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

3 Jan 1h 22min

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