Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living3 Apr 2019

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
The mitochondria in your cells make energy (ATP)
There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
Cancer cells ferment - therefore they don't use oxygen
Not all cancer cells have genetic mutations, but all cancer cells ferment
The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
On the other hand, normal cells use oxygen and very little amounts of glucose
This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
Have to re-emphasize the fact that the DNA damage comes as a downstream effect
Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
The oxidative stress also causes damage to the nucleus and the genome
The field of cancer research studies effects instead of causes
We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
This is supported by thousands of experiments and studies
Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
Cancer cells can't use ketones
There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
Basically nobody he's heard of is treating it this way
If it's so clear this is how cancer works, why has this not reached the mainstream?
The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
Entrenched beliefs continue this. Also funding money is all based around the genetic theory
If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
Cancer is a result of the industrialization as a society
Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
These are all secondary - the root cause is damage to the respiration
Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
Metabolic therapies need to at least be options for people
Problem is doctors aren't aware of them or aren't trained on them
Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
There's therapeutic weight loss and toxic weight loss
Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
ROS damages tissues and is why you age
He published the glucose-ketone index calculator
People need to realize sweets are a treat once in awhile - not an everyday thing
The food industry has played into our ancient desires for sweet
Otto Warburg studied cancer in the early 1900s
He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
Because their mitochondria are defective they can't switch back to oxidative phosphorylation
He recently published a paper filling in the gaps from Otto Warburg's work
Missing link was the glutamine that cancer cells can also use
Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
He's developed the press-pulse system in his lab to attack tumors strategically
Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
He's having trouble getting funding for this for some reason
One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
People are going to have to participate in the management of their disease and the culture of the diseases has to change
Another problem is the high cost of these standard therapies - people have to pay $400k
His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
The wheelchair doesn't cause your legs to not work
Needle biopsies are putting people at risk and are pointless
He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
What do critics of his views say? They try to create doubt
They rely on private funding and some great organizations supporting this research
Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
Dr. George Yu's foundation https://yufoundation.org
Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Part 229 -Reviving Regenerative Agriculture with Will Harris

Will Harris is known for his pioneering regenerative agriculture practices. The episode explores Harris's journey from traditional farming to regenerative agriculture, the economic challenges, and the impact on land, community, and ecosystems. Harris shares insights from his experiences, including his transition away from chemical-dependent farming and the development of vertically integrated operations. They discuss the benefits of regenerative practices, the difficulties in marketing and scaling, as well as the broader implications for nutrition and sustainability. Lastly, the episode addresses the sustainability of feeding the world through regenerative practices, emphasizing local community support and the long-term generational benefits. 05:10 Introduction to Will Harris 09:05 Challenges and Evolution in Farming Practices 29:43 The Impact of Erosion on Soil Health 30:09 Scientific Comparison: Monocrop vs. Diverse Ecosystem 30:48 Economic Challenges of Transitioning to Regenerative Farming 31:49 The Rise of Grass-Fed Beef and Market Challenges 33:00 Educating Consumers on Grass-Fed Beef 35:03 The Influence of Propaganda on Food Choices 42:18 The Role of Debt in Farm Management 44:15 Challenges in Poultry Farming 50:31 The Benefits of Regenerative Agriculture 53:31 Feeding the World Sustainably 01:00:20 Reflections on the Future of Regenerative Farming BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Okt 1h 2min

Sapien Podcast- Fiber Myths, Vitamin C Lies, and the Fight for Root-Cause Health with Chris Kruger

In this episode of the Sapien Podcast, Chris Kruger returns as co-host with Brian Sanders for a deep dive into nutrition myths, fiber fallacies, and the failures of mainstream dietetics. Together, they expose how official guidelines and academic institutions push confusion for profit while ignoring root-cause solutions. The hosts critique health narratives around fiber, red meat, vitamin C, and weight-loss drugs, while sharing client case studies that reveal the real path to metabolic health. They emphasize the Sapien approach: whole foods, animal-based nutrition, hormone balance, and lifestyle over pills and procedures. SHOW NOTES: 04:00 The Football Analogy: nutritionists misunderstand cause and effect 06:00 Debunking fiber myths and why whole foods matter most 09:00 Case study: reversing lifelong constipation with a low-fiber diet 12:00 Red meat, healthy user bias, and flawed nutrition studies 14:30 Academia, food industry funding, and distorted guidelines 15:30 Carnivore diets and the vitamin C myth 18:00 Beyond "calories in, calories out" 27:00 Defining metabolic syndrome vs. metabolic excellence 30:00 Statins, side effects, and why lifestyle beats prescriptions 32:00 Hormone health as the foundation of motivation and vitality BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Okt 37min

Sapien Podcast- Fitness Wisdom Unplugged

In this episode of the Sapien Podcast, Chris Krueger joins the show as a new co-host along with host Brian Sanders. They introduce the podcast as a fun, unplanned discussion about health, fitness, and hormone optimization. The hosts share personal fitness stories and emphasize the importance of a holistic approach to health, advocating for living naturally and avoiding artificial supplementation like TRT. They critique Brian Johnson's extreme health regimens and promote practical, actionable steps for achieving and maintaining elite health without extensive gym workouts or complex diet plans. SHOW NOTES: 00:00 Introduction to the Sapien Podcast 01:11 Fitness and Hormone Optimization 01:25 Generational Fitness and Relatability 01:43 Chris's Fitness Feats and Midlife Reflections 04:57 The Importance of Staying Active 05:38 Family Dynamics and Health Advice 08:01 The Sapien Lifestyle and Hormone Balance 14:16 Insulin and Metabolic Health 17:31 Raw Milk and Sapien Center Community 18:42 Farmer's Market Raw Milk Prices 20:43 Brian Johnson's Cult-Like Brunch 22:03 The Profit in Food Processing 25:31 Debunking Diet Myths BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

22 Okt 35min

Part 228 - Dr. Doug McGuff on High-Intensity Training, Recovery, and the Truth About Nutrition

Dr. Doug McGuff is an emergency physician, exercise researcher, and co-author of Body by Science. Known for his pioneering work in high-intensity resistance training, McGuff blends decades of medical practice with deep knowledge of physiology to reveal how short, focused workouts can yield extraordinary health benefits. He also runs training studios in South Carolina that specialize in safe, supervised strength training. In this episode of Peak Human, Brian Sanders and Dr. McGuff dive into why most people misunderstand exercise, the dangers of overtraining, and how nutrition and movement fit together for long-term health. They cover everything from the "12-minute workout" to the role of myokines, why VO₂ max is misunderstood, and how subsidies and processed foods hijacked the human diet. This conversation reframes what it truly means to build strength, resilience, and health for life. Show Notes: 03:00 Dr. McGuff's Background: Emergency Medicine & Strength Training 07:00 Adaptive Resistance Training (ARX) & How It Works 14:00 The Physiology of Strength: Motor Units & True Failure 22:00 The "12-Minute Workout" – Time Efficiency & Maximum Results 25:00 Overtraining, PEDs, and the Myths of Modern Fitness Culture 28:00 Long-Term Damage from Inefficient Training Methods 30:00 You Can't Out-Exercise a Bad Diet 33:00 The Straight Line Between You and the Sun – Whole Food Nutrition 44:00 Debunking the Meat & Gout Myth 48:00 Eat Densely, Move Intensely – Rethinking Fitness Advice 49:00 Cardio Myths, VO₂ Max, and the Zone 2 Obsession 56:00 What Really Correlates With Longevity: Adaptation, Not Numbers BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Sep 1h 14min

Part 227 - Holistic Health, Slow Food, and Lifelong Vitality with Tara Couture

In this episode of Peak Human, host Brian Sanders welcomes back Tara Couture. Tara, a renowned advocate for the Sapien lifestyle, shares insights into her holistic approach to health, which includes growing her own food and embracing a nutrient-dense diet. The discussion covers various topics, including nutrition, lifestyle factors, nature, hormone optimization for both men and women, and practical tips for adopting this lifestyle even in urban settings. Tara also discusses her new book, 'Radiance of the Ordinary,' which explores the profound rewards of living authentically and nourishing one's body. Brian also highlights the benefits of natural supplements like oyster pills for hormone optimization. A must-listen for anyone interested in sustainable living and holistic health. Show Notes: 00:15 Tara's Lifestyle and Farmstead 00:59 Nutrition and Lifestyle 07:46 Raising Healthy Children 15:36 Cooking and Food Preparation 31:45 Travel and Eating Healthy 35:10 Carbs and Diet Adjustments 36:42 Exploring the Benefits of Carbs 38:00 Introducing Tara's Book: Radiance of the Ordinary 38:46 The Dichotomies of Life and Embracing Mortality 43:33 The Importance of Real Food and Nutrition 48:13 Men's Health and Hormones 57:41 The Simplicity of Whole Foods 01:05:54 The Gift of a Healthy Body BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Tara's Book: https://www.penguinrandomhouse.com/books/798098/radiance-of-the-ordinary-by-tara-couture/ Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

3 Sep 1h 12min

Part 226 - Biohacking and Homesteading: Bridging the Gap with Michael Kummer

In this episode, Brian Sanders chats with Michael Kummer about his multifaceted approach to health and wellness, which combines elements of biohacking, fitness, and homesteading. Kummer, a proponent of the 'Sapien' philosophy, emphasizes a diet and lifestyle that closely mimic natural human behaviors. The discussion covers Michael's fitness routine, which involves minimal gym time, his creation of an accessible fitness program, and his unique perspective on the synergy between biohacking and homesteading. They delve into the issue of modern diets, stress, and lifestyle factors impacting health, using Austria as a case study to highlight these trends. Kummer also shares insights into his family's transition to a homesteading lifestyle and offers practical tips for integrating these principles into various lifestyles. Try the oyster pills! https://nosetotail.org/products/pure-oyster Show Notes: 02:18 Biohacking vs. Natural Living 04:12 Homesteading and Food Production 08:45 Health Impacts of Modern Lifestyle 12:03 Traditional Food Preparation Techniques 24:41 The Importance of Muscle Mass 28:12 Austrian Lifestyle and Longevity 33:02 Traditional Austrian Diet: Then and Now 33:16 Impact of World War II on Diet and Lifestyle 35:32 Modern Austrian Diet and Health Trends 37:46 Comparing Health Outcomes: Austria vs. USA 45:38 Personal Fat Threshold and Its Implications 51:52 Homesteading and Sustainable Living 54:21 Balancing Modern Life with Traditional Practices 58:21 The Role of Community in Homesteading 01:03:13 Supplements and Whole Foods for Optimal Health BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

13 Aug 1h 6min

Part 225 - Unlocking the Secrets of Satiety Per Calorie with Dr. Ted Naiman

In this episode of Peak Human, host Brian Sanders interviews Dr. Ted Naiman, discussing the concept of satiety per calorie and its implications for diet and health. They dive into the importance of understanding different diet patterns, focusing on high-protein, nutrient-dense foods, and avoiding overly processed foods. The conversation covers the four pillars of satiety per calorie: protein percentage, energy density, fiber content, and hedonics. Dr. Naman also talks about his new book 'Satiety Per Calorie,' which aims to provide a comprehensive understanding of diet and nutrition, helping people make informed food choices to maintain optimal body composition effortlessly. The episode concludes with discussions on the benefits of natural exercise routines and natural supplements for overall health. Try the oyster pills! https://nosetotail.org/products/pure-oyster Show notes 00:28 Understanding Diets and Nutrition 01:28 Exercise and Fitness Insights 02:09 Oyster Pills and Testosterone Boost 03:15 Daily Life and Health Philosophy 03:53 Satiety and Nutrient Density 05:38 The PE Diet and Satiety Per Calorie 06:34 Explaining Diet Patterns and Health Outcomes 12:48 Practical Tips for Diet and Exercise 41:09 Understanding Protein Leverage and Obesity 44:07 Can You Get Fat on Protein? 45:47 Nutrient Calories vs. Energy Calories 49:33 The Four Pillars of Satiety Per Calorie 54:42 The Role of Fiber in Satiety 01:01:38 Energy Density and Caloric Intake 01:07:01 The Liver's Role in Metabolism REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

6 Aug 1h 14min

Part 224- Boosting Health with Oysters: Conversations on Deep Nutrition with Marine Biologist Stephen Kavanagh

In this episode of Peak Human, host Brian Sanders delves into a comprehensive discussion with marine biologist Stephen Kavanagh, an expert in shellfish and particularly oysters. Brian and Stephen explore the nutritional benefits of oysters, including their historical significance in human evolution and their roles in promoting testosterone, immunity, and overall health. Stephen details his artisanal processes at his facility in Ireland, emphasizing the purity and nutrient density of oysters used in their products. The conversation expands into broader themes of deep nutrition, the slow food movement, and the importance of returning to nature's ratios in our diets. Listeners also receive insights into the issues surrounding processed foods and modern health epidemics like obesity. Try the oyster pills! https://nosetotail.org/products/pure-oyster Show Notes: 02:25 The Journey of Oyster Processing and Supplement Manufacturing 06:02 The Aphrodisiac Effect of Oysters 10:00 Nutritional Benefits and Historical Significance of Oysters 14:18 The Importance of Real Food and Avoiding Processed Foods 15:03 Challenges in the Oyster Industry and Food Lies 20:06 The Synergy of Nutrients and Fortified Foods 26:49 Ancient Diets and the Role of Oysters in Human Evolution 28:48 The Nutritional Power of Oysters 29:41 Evolutionary Benefits of Oysters 31:21 Human Connection to Marine Life 32:17 Oysters and Water Quality 33:01 Oyster Pure: Quality and Testing 34:06 Personal Health Benefits of Oyster Supplements 35:29 Challenges in Marketing Oyster Supplements 43:39 The Slow Food Movement BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

31 Juli 56min

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