Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity
Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living3 Apr 2019

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

  • Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
  • The mitochondria in your cells make energy (ATP)
  • There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
  • Cancer cells ferment - therefore they don't use oxygen
  • Not all cancer cells have genetic mutations, but all cancer cells ferment
  • The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
  • This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
  • The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
  • On the other hand, normal cells use oxygen and very little amounts of glucose
  • This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
  • Have to re-emphasize the fact that the DNA damage comes as a downstream effect
  • Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
  • The oxidative stress also causes damage to the nucleus and the genome
  • The field of cancer research studies effects instead of causes
  • We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
  • This is supported by thousands of experiments and studies
  • Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
  • We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
  • Cancer cells can't use ketones
  • There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
  • Basically nobody he's heard of is treating it this way
  • If it's so clear this is how cancer works, why has this not reached the mainstream?
  • The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
  • Entrenched beliefs continue this. Also funding money is all based around the genetic theory
  • If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
  • Cancer is a result of the industrialization as a society
  • Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
  • Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
  • These are all secondary - the root cause is damage to the respiration
  • Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
  • To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
  • Metabolic therapies need to at least be options for people
  • Problem is doctors aren't aware of them or aren't trained on them
  • Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
  • There's therapeutic weight loss and toxic weight loss
  • Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
  • Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
  • Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
  • ROS damages tissues and is why you age
  • He published the glucose-ketone index calculator
  • People need to realize sweets are a treat once in awhile - not an everyday thing
  • The food industry has played into our ancient desires for sweet
  • Otto Warburg studied cancer in the early 1900s
  • He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
  • Because their mitochondria are defective they can't switch back to oxidative phosphorylation
  • He recently published a paper filling in the gaps from Otto Warburg's work
  • Missing link was the glutamine that cancer cells can also use
  • Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
  • He's developed the press-pulse system in his lab to attack tumors strategically
  • Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
  • He's having trouble getting funding for this for some reason
  • One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
  • People are going to have to participate in the management of their disease and the culture of the diseases has to change
  • Another problem is the high cost of these standard therapies - people have to pay $400k
  • His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
  • If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
  • The wheelchair doesn't cause your legs to not work
  • Needle biopsies are putting people at risk and are pointless
  • He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
  • What do critics of his views say? They try to create doubt
  • They rely on private funding and some great organizations supporting this research
  • Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
  • His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
  • Dr. George Yu's foundation https://yufoundation.org
  • Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
  • Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Part 208 - Mary Ruddick Debunks the Blue Zones and Explains Worldwide Health Decline

Part 208 - Mary Ruddick Debunks the Blue Zones and Explains Worldwide Health Decline

Mary Ruddick is an internationally acclaimed nutritionist currently based in Europe and Africa. She has personally trained professional nutritionists around the globe. Dubbed the "Sherlock Holmes of Health" for her unique ability to expeditiously assess and remediate rare neuromuscular conditions that others have deemed impossible, Mary Ruddick is a seasoned researcher, educator, medical nutritionist, entrepreneur, and philanthropist. Her writing has been published in medical journals and her own inspirational healing story can be found in several publications. http://enableyourhealing.com BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (10:38) The Maasai people who live the most traditional lifestyles are living what us moderns would consider a "utopia". (22:32) The mental health crisis came as a result of being unhealthy in general. (28:12) When you eat organ meat, you take in a lot of serine. (34:34) Another practice within these indigenous cultures is that there is no trading of food, meaning everything eaten is native. Their food is also traditionally processed. (45:25) You don't need to completely remove plants from your diet, but gravitate towards those that you enjoy eating and have been properly prepared to minimize toxicity. (53:12) When optimizing your nutrition, don't focus on achieving balance. Focus on avoiding deficiencies. (1:08:42) There are different levels of nutritional knowledge. (1:21:17) The concept of "Blue Zones" as presented in the mainstream is largely misrepresented. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Nov 20231h 34min

Part 207 - Veronica Max, APRN, FNP on Your Complete Health Makeover

Part 207 - Veronica Max, APRN, FNP on Your Complete Health Makeover

Veronica Max is a nurse practitioner and the CEO of UltraPersonal Healthcare. Bringing more than eleven years of family and functional medicine experience to the table, Veronica founded UltraPersonal Healthcare with the aim of creating a quality of care, service and experience that she found missing in the modern healthcare system. Just tell her Brian sent you! https://www.ultrapersonal.healthcare BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (12:24) Find a healthcare practitioner that focuses on preventing disease rather than treating disease. (16:14) Terrain theory takes into account the human body and the health of the organism. (23:31) Exposure to the sun and the elements is vital to a healthy body with normal levels of sex and thyroid hormone. (36:40) A healthy diet involves meat, fish, and seasonal fruits and vegetables. (41:44) There's ancient wisdom in the fact that all the major religions incorporate fasting. (47:21) Hashimoto's is autoimmune hypothyroidism (underactive thyroid). (55:57) Calorie restriction is a form of stress. (1:02:02) Movement is important. But if you overlook food and light, you won't meet your goals. (1:08:30) It's no coincidence that the thyroid is in the throat. (1:11:29) There's no right or wrong place for a woman to have her baby. It's important to know your options. (1:14:32) When it comes to your child's immunization schedule, it's important to educate yourself and to listen to your intuition as a parent. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

25 Okt 20231h 19min

Part 206 - Chris Kruger on How to Lose Fat the Easy Way

Part 206 - Chris Kruger on How to Lose Fat the Easy Way

Chris Kruger is a fitness coach and a promoter of the high-testosterone lifestyle. At 40 years old, he has already dedicated two full decades to assisting men worldwide in achieving their peak potential – in appearance, well-being, and overall performance – all without the need for pills, powders, prescriptions, or PEDs/TRT. http://Instagram.com/krugerbody Just DM him you want to do the SAPIEN program ck@testosteronesuperchallenge.com BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (06:19) Natural hormone optimization applies to men just as much as it applies to women. (07:20) A calorie deficit for weight loss purposes is only effective in the short-term. (16:15) Instead of restricting yourself nutritionally while trying to improve or maintain performance, go for naturally optimizing your hormones. (26:55) Don't think "energy balance". Think "energy metabolism". (37:28) True health or fitness is about living like a human should to the fullest. (53:04) Testosterone can be produced from saturated fat. (1:01:52) Your health and fitness is a reflection of the relationship you have with yourself. (1:22:46) Outside of sleep, the biggest lever you can pull is getting enough protein. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

19 Okt 20231h 32min

Part 205 - Dave Feldman on The Amazing Study of Fit People w/ High LDL Cholesterol

Part 205 - Dave Feldman on The Amazing Study of Fit People w/ High LDL Cholesterol

Dave Feldman is an independent researcher and software engineer who has gained notoriety for his work on cholesterol and lipid metabolism, particularly in the context of low-carbohydrate and ketogenic diets. Coming from a background in software engineering, Feldman took a systems engineering approach to understanding cholesterol, creating what he calls the "lipid energy model." He has presented his findings at various medical conferences and is a frequent guest on health and wellness podcasts. Although not a credentialed medical professional, Feldman's citizen science has challenged traditional views on cholesterol, encouraging more nuanced discussions around its role in health. His work has captivated a large following of both laypeople and experts interested in the complexities of lipidology. http://CholesterolCode.com BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (4:18) A study on the Lipid Energy Model (LEM) (https://pubmed.ncbi.nlm.nih.gov/35629964/) may explain why cholesterol increases in those who decide to consume fat for energy over carbs. (12:46) The status of your metabolic health influences how a particular diet affects your health, no matter the diet. (20:42) HDL at 50 or higher and triglycerides at 100 or lower are good benchmarks to strive for. (36:19) Multiple studies demonstrate that, if you take 100 random people in the same demographic with 0 risk factors, 60 male and 40 female, a little more than half of them would have 0 CAC. (44:07) Dave's ongoing companion study (follow updates at https://citizensciencefoundation.org/) running parallel to the main study features a control group with more relaxed criteria. (52:03) If we had more data on healthy populations, a clearer path towards a healthy way of life will be achieved (59:40) Visit (https://ownyourlabs.com/) which is both a blood testing service and a hub to participate in citizen science. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

4 Okt 202356min

Part 204 - Gabor Erdosi on The Root Cause of Diabetes, Disease, and Obesity

Part 204 - Gabor Erdosi on The Root Cause of Diabetes, Disease, and Obesity

Gabor is a food scientist with a master's in molecular biology. He lives in Hungary and is one of these engineers/scientists who I love talking to who look at nutrition differently. He has a very unique perspective because he worked for big food manufacturers. He spends almost all of his free time researching this stuff to help people understand how bad these processed foods actually are. He has a large community on Facebook where he shares and discusses this information. He also has some great presentations he's done you can find online. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (12:29) To determine whether a study is biased, refer first to potential conflicts of interest. (14:56) Adipose tissue is a question of function over mass. (23:53) We are adaptive organisms. (31:04) Accelerated Appearance and Absorption (AAA) takes place when your small intestinal tract is filled too quickly with ultra-processed foods (refined carbs and/or added fats). (41:03) Processed proteins are nowhere near as unhealthy as processed carbs. (55:40) Overeating doesn't necessarily equal gaining weight, and vice versa. (58:36) Adipogenesis is the generation of more fat mainly through the addition of new fat cells. (1:09:19) In general, metabolic health is a good marker of future health outcomes. (1:17:58) A diet rich in refined carbohydrates and added fats leads to the production of endotoxins that are easily absorbed. (1:27:46) Visceral fat is a protective mechanism. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Sep 20231h 28min

Part 203 - Dr. Joel Kahn Thinks You Should Go Vegan

Part 203 - Dr. Joel Kahn Thinks You Should Go Vegan

Dr. Joel Kahn is a cardiologist, integrative medicine practitioner and promoter of plant-based nutrition. Having practiced traditional cardiology since 1983, it was only after his own commitment to a plant based vegan diet that he truly began to delve into the realm of non-traditional diagnostic tools, prevention tactics and nutrition-based recovery protocols. These ideologies led him to change his approach and focus on being a holistic cardiologist. https://www.drjoelkahn.com/ GET THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (16:52) According to Dr. Khan, if you suffer from heart disease, consider a plant-based diet based on science. (20:38) We start to develop atherosclerosis in our 20s and 30s. (31:00) We have more than enough data that a human can live through their reproductive years on a huge variety of diets. (47:08) To assess whether or not you're on the right path, assess your own cardiovascular status. (59:54) 30-40% of heart attacks, strokes, and early deaths are due to genetic factors, completely regardless of nutrition and lifestyle. (1:09:50) Examine whether or not your lifestyle is working for you. Don't just assume it is. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

20 Sep 20231h 13min

Part 202 - Stephan Guyenet, PhD on Why Do Humans Overeat?

Part 202 - Stephan Guyenet, PhD on Why Do Humans Overeat?

Stephan J. Guyenet, Ph.D. is an obesity researcher and health writer whose work ties together neuroscience, physiology, evolutionary biology, and nutrition to offer explanations and solutions for our global weight problem. He received a B.S. in biochemistry at the University of Virginia and a Ph.D. in neurobiology at the University of Washington. He is the author of the popular health website, Whole Health Source, and is a frequent speaker on topics of obesity, metabolism, and nutrition. https://www.stephanguyenet.com/about-stephan-guyenet/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (11:16) Our brains determine our food intake and regulate our energy expenditure, in a way that works best in our ancestral environment, but not in our modern environment. (24:33) We consume calories for many reasons, hunger being just one of them. Likewise, satiety is just one of many reasons we stop eating. (34:40) As a rule of thumb, eat a diet of omnivorous whole foods that are lower in calorie density. (49:56) Fiber is not an essential nutrient. (58:35) Nutrient-to-energy is important to health, but once you have adequate intake, there's not much benefit in taking in more. (1:04:46) Most people in the US are more susceptible to obesity than others. Whether or not they actually become obese comes down to the environment they choose. (1:15:31) Blood pressure, on a genetic level, doesn't typically change as one gets older. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

12 Sep 20231h 26min

Part 201 - Brad Kearns on Finding the Holy Grail of Diet & Lifestyle

Part 201 - Brad Kearns on Finding the Holy Grail of Diet & Lifestyle

Brad Kearns, 58, is a New York Times bestselling author, Guinness World Record setting professional Speedgolfer, #1 USA-ranked Masters age 55-59 track & field high jumper in 2020, and former national champion and #3 world-ranked professional triathlete. He has written twenty books on diet, health, peak performance, and ancestral living, and is a popular speaker, retreat host, and face of the Primal Blueprint online multimedia educational courses. In 2017, The Keto Reset Diet became a New York Times bestseller, and briefly ranked as the #1 overall bestselling book on amazon.com. Brad also hosts the B.rad podcast BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (09:56) We know what's possible. Now let's shoot for optimal. (21:22) Processed foods disrupt our appetite and satiety hormones, prompting us to overeat. (33:02) Injuries are a sign of overdoing it. (40:56) Homo sapiens are built for near-constant everyday movement. (47:38) Always ask "what's optimal" instead of just "what's possible". (59:54) Raw forms of high-toxin natural plant foods is a potentially problematic category of nutrition. (1:08:26) Our main nutritional challenge is energy toxicity. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

31 Aug 20231h 24min

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