Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Part 35 - Dr. Thomas Seyfried on Cancer as a Metabolic Disease, More Effective Therapies, and Treating it Without Toxicity

Dr. Thomas Seyfried is a Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois. He then worked as an assistant professor in the neurology department at the Yale school of medicine. He has over 180 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease. He recently received a Lifetime Achievement Award from the Academy of Complimentary and Integrative Medicine.

I got a chance to meet and interview him at the Metabolic Health Summit earlier this year. You'll notice we did this podcast shortly after the Super Bowl. In case people aren't familiar with American football the New England Patriots had just beaten the LA Rams.

I hope people look up the paper he recently published that we mention and watch his presentation I linked to in the show notes and go deeper on this topic. It's very surprising to learn of this completely new view on cancer if you haven't heard of it before. This really shouldn't be very surprising to anyone, however, because of course our modern diet and lifestyle would have the biggest effect on the rising cancer rates. And of course fixing these things would also be a major part of the treatment. He's really doing legendary work. So without further ado, here's professor Seyfried.

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Show Notes

  • Dr. Thomas Seyfried believes cancer is a metabolic disease, not a genetic disease and explains in simple terms why that is
  • The mitochondria in your cells make energy (ATP)
  • There's 2 types of energy: ancient energy which is a fermentation metabolism which means you can make energy without oxygen, or respiration where you make energy from breathing air
  • Cancer cells ferment - therefore they don't use oxygen
  • Not all cancer cells have genetic mutations, but all cancer cells ferment
  • The mitochondrial metabolic theory says that the organelle that makes energy from respiration is defective, forcing the cell to ferment. When the cell ferments, mutations collect in the nucleus
  • This means the genetic mutations seen in cancer cells come from a downstream effect of disruption of energy metabolism
  • The cancer cell has to consume a large amount of glucose and the amino acid glutamine in order to survive on a fermentation metabolism
  • On the other hand, normal cells use oxygen and very little amounts of glucose
  • This should make sense to a lot of people because they've probably heard cancer cells need a lot of glucose and if you starve them of that they die
  • Have to re-emphasize the fact that the DNA damage comes as a downstream effect
  • Damaged mitochondria, instead of making ATP, make Reactive Oxygen Species (ROS) or oxidative stress (which causes a lot of problems in our body)
  • The oxidative stress also causes damage to the nucleus and the genome
  • The field of cancer research studies effects instead of causes
  • We're not treating cancer by looking at the root cause - it's absurd - how would we ever cure it?
  • This is supported by thousands of experiments and studies
  • Obvious step to treat cancer is to deprive the cancer cells of glucose and glutamine and transition healthy cells into the use of ketones which they can readily use
  • We evolved as a starving creature and convert fatty acids into ketones and usable forms of energy
  • Cancer cells can't use ketones
  • There's no dietary way to restrict glutamine to the cancer cells so drugs have to be used
  • Basically nobody he's heard of is treating it this way
  • If it's so clear this is how cancer works, why has this not reached the mainstream?
  • The Federal government puts out websites saying cancer is genetic, medical schools teach it's genetic, leading cancer clinics tell patients it's genetic
  • Entrenched beliefs continue this. Also funding money is all based around the genetic theory
  • If you look at the mitochondria of any cancer cell under an electron microscope you can easily see the damage to the organelles and mitochondria
  • Cancer is a result of the industrialization as a society
  • Cancer is so rare throughout history or with non-industrialized societies they don't even have the word for it in their language
  • Cancer comes from all kinds of things like pollution, chemicals, radiation, hypoxia, infections, chronic inflammation, even some rare inherited diseases like BRCA1 (but it has to damage the mitochondria)
  • These are all secondary - the root cause is damage to the respiration
  • Obese people have higher rates of cancer and also higher inflammation (measured by C reactive protein)
  • To avoid cancer it's as simple as avoiding diets and lifestyles that risk damage to the mitochondria
  • Metabolic therapies need to at least be options for people
  • Problem is doctors aren't aware of them or aren't trained on them
  • Therapeutic ketosis is a medicine - it's different than just a diet (which is a turn-off to a lot of medical professionals)
  • There's therapeutic weight loss and toxic weight loss
  • Using a suite of therapies to cure cancer including ketogenic metabolic therapy and hyperbaric oxygen therapy
  • Hyperbaric oxygen creates reactive oxygen species that kills cancer cells but healthy cells using ketones are protected from oxidative stress and are fine
  • Burning ketones creates less ROS (which is a good thing) and is why many people without cancer eat a ketogenic diet
  • ROS damages tissues and is why you age
  • He published the glucose-ketone index calculator
  • People need to realize sweets are a treat once in awhile - not an everyday thing
  • The food industry has played into our ancient desires for sweet
  • Otto Warburg studied cancer in the early 1900s
  • He found that cancer cells would grow in an 100% oxygen environment - they continue to ferment and create lactic acid
  • Because their mitochondria are defective they can't switch back to oxidative phosphorylation
  • He recently published a paper filling in the gaps from Otto Warburg's work
  • Missing link was the glutamine that cancer cells can also use
  • Have to pulse the glutamine so the immune system can do it's job and clear out the dead cells
  • He's developed the press-pulse system in his lab to attack tumors strategically
  • Almost there with dosage, timing, and schedule - when done with this will have the pathway to resolution
  • He's having trouble getting funding for this for some reason
  • One problem is people have created separate little communities and foundations around their specific type of cancer even though they all have the common metabolic foundational problem
  • People are going to have to participate in the management of their disease and the culture of the diseases has to change
  • Another problem is the high cost of these standard therapies - people have to pay $400k
  • His paper looking at research conducted on cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941741/
  • If you take a normal cytoplasm and implant a nucleus with a tumor you get normal cells. But if you implant a normal nucleus to a cell with damaged cytoplasm, you get more tumor cells. This shows it's the damaged mitochondria in the cytoplasm, not the DNA in the nucleus
  • The wheelchair doesn't cause your legs to not work
  • Needle biopsies are putting people at risk and are pointless
  • He calls this general misunderstanding of cancer the biggest tragedy in the history of medicine
  • What do critics of his views say? They try to create doubt
  • They rely on private funding and some great organizations supporting this research
  • Travis Christofferson's foundation https://foundationformetaboliccancertherapies.com
  • His book Tripping Over the Truth https://www.amazon.com/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/
  • Dr. George Yu's foundation https://yufoundation.org
  • Presentation by Dr. Seyfried https://www.youtube.com/watch?v=APwnkpD_BfI&frags=pl%2Cwn
  • Dr. Seyfried's book https://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920/

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Avsnitt(235)

Part 163 - Jayne Buxton on The Great Plant Based Con

Part 163 - Jayne Buxton on The Great Plant Based Con

On this episode, Brian speaks with the renowned author and journalist Jayne Buxton. Jayne had published several books, non-fiction and fiction, on various subjects, but had a strong passion for regenerative agriculture, nutritional research and advocacy for animal products.  She is the author of the recently released book, The Great  Plant-Based Con, which is discussed today.  Jayne is also an ambassador for The Real Food Campaign and The Public Health Collaboration, while also having written for publications such as The Guardian and The Independent.   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES: [3:00] Jayne and Buxton speak on their books/film and what inspired them to start that path [5:15] - Brian and Jayne share their experience with the USDA scientist David Klurfeld  who blew the whistle on the WHO study which demonized Meat  [9:25] - The high-level view of plant-based arguments  [14:10] - Diving into the nutritional differences in omnivore and vegetarian diets and their relation to health [29:30] - the ramifications of Ancel Keys and the demonization of saturated fat, cholesterol and their association to heart disease  [49:40] - The propaganda and narrative behind the environmental arguments in the plant-based agenda  [1:12:00] - Where the globalization behind the plant-based agenda is leading to [1:17:00] - Getting the book and moving forward   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Juni 20221h 27min

Part 162 - L. Amber O'Hearn on Should Humans Eat Mostly Fat and the Rest Meat?

Part 162 - L. Amber O'Hearn on Should Humans Eat Mostly Fat and the Rest Meat?

Amber O'Hearn has an eclectic background, with academic publications in several fields including theoretical mathematics, cognitive psychology, computational linguistics, and more recently, evolutionary nutrition and biology. She has been studying and experimenting with low-carb, ketogenic diets since 1997, and is particularly interested in evolutionary constraints and interspecies differences. Amber has been eating a nearly plant-free diet since 2009 Ambers Website Mostly-fat.com BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES [1:00] - Amber's background, history, education and interests related to nutrition and a long-term carnivore lifestyle [9:00] - Amber's introduction in 2009 to keto and carnivore through pregnancy [15:45] - Plant antinutrients and health [24:40] - Carnivore + Fruit and Ray Peat [34:35] - "Zooming out" on Plants vs Meat studies and the risks vs costs [42:45] - Plant compounds, antioxidants and oxidative stress [53:00] - Ineffectiveness of RDA's based on individual diets and vitamin deficiencies [1:03:15] - mTOR, Valter Longo, and longevity diets [1:14:30] - High fat diet vs. high protein [1:20:35] - Can the Carnivore community fall into the vegan community nutrient deficiency trap? BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

8 Juni 20221h 32min

Part 161 - Dr. Frederic Leroy Unravels 100 years of the Anti-Meat Agenda

Part 161 - Dr. Frederic Leroy Unravels 100 years of the Anti-Meat Agenda

Specializing in the science and application of animal foods in society and nutrition, Dr. Frederic Leroy is a food scientist, technologist and professor at the University of Brussels. With a dense background in peer-reviewed journals, academic boards, and nonprofits, Dr. Leroy currently is an advocate for a deeper, more nuanced discussion of the importance of animal products, an understanding our our historic relationships with them, and the current war against them in western cultures. Frederic's Twitter Page Watch on YouTube: https://youtu.be/lKGeRAB-K3E Dr. Leroy's slides: https://drive.google.com/file/d/1z7l1vmwCWPnHbyS4BVP-1dx6Jo46dP_a/view?usp=sharing GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [4:10] - Brian and Frederic discuss how the overall health of a society relates to diet and nutrition and how modern fake food plays into them [12:15] - How fake meat corporations are trying to make animal agriculture industry disappear [15:30] - Our connection to butchering, modern animal butchering and how they play into our separation to our ancient ways of living [26:50] - Diving into sensationalism in DailyMail articles since 2000 around Meat [32:50]- Why nuance and context always matters when speaking about foods and specifically meat [35:50] - Do we need meat? Is it fundamental to health? [47:20] - How meat, animal foods, and our relationships to animals provided security for hunter-gatherer communities interactions with animals is changing: slaughtering, butchering, consumption [1:108:30] - The hierarchy of our modern society and the agendas to form mobs, embrace authority, and subvert power [1:22:00] - How our view of death has changed and its role in our our view of meat/animal products [1:29:00] - How to have a societal and individual relationships with animals that are healthy for you, the community and the earth GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

1 Juni 20221h 47min

Part 160 - Kara Collier on Optimal Health Through Blood Sugar Regulation

Part 160 - Kara Collier on Optimal Health Through Blood Sugar Regulation

Kara Collier is a Registered Dietician Nutritionist and a co-founder of Nutri-Sense, currently leading their team of dieticians to using their continuous glucose monitoring systems to help individuals properly manage their glucose and metabolism. She graduated from Purdue University, previously worked at the Memphis VA medical center as a clinical dietician at Providence Hospital and in a management role at Nutritionix   Use code "PeakHuman" at Nutrisense for $25 off a CGM     GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES [0:30] - Kara details her past and what motivated her to get involved with healthcare, metabolic health and Nutrisense and [5:00] - How using a continuous glucose monitor can increase your awareness of how foods affect your glucose levels, energy, mood etc. [14:30] - How your body adapts to lower levels of carbohydrates in diet and its effects [16:30] - Detailing glucose and its role in metabolism [20:30] - What is a Continuous Glucose Monitor, what it tells you and who might benefit from using it [25:05] - Why Hemoglobin A1c is not the only indicator of your metabolic health and what can make those results less reliable [34:15] - Why its very hard and uncommon for the traditional healthcare system to prescribe beneficial testing as preventative care [41:10] - Lipids, LDL, HDL, Trigs and how their levels affect overall health [48:15] - Lifestyle factors and basic nutrition guidelines to maximize glucose response and metabolic health [58:00] - How Sleep and Alcohol affect glucose response and health [1:11:00] - How larger meals, like an OMAD format, affects your glucose response and metabolism [1:16:00] - Do we know if eating a bunch of fruit and sugar is good/bad?   BUY THE MEAT NosetoTail.org Support me on Patreon! http://patreon.com/peakhuman Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

25 Maj 20221h 24min

Part 159 - Patrick Theut on the Miraculous Reversal of Heart Disease

Part 159 - Patrick Theut on the Miraculous Reversal of Heart Disease

Patrick Theut is a biochemist and engineer who has successfully managed to reverse his coronary artery disease. He has invested over 16,000 hours of study into the cause of heart disease. He has developed theories and protocols on how this disease is developed, how to stop it from progressing, and protocols to even reverse it. Vitamin K Website The ancestral health & events center in East Austin is getting closer to becoming a reality! Email Brian at hi@foodlies.org to get involved. We're looking for anyone from members to investors! GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES [3:50] - Patrick details his life-changing scare with a high Coronary Artery Calcium score [14:04] - Why he thinks a MMR jab negatively affected his life [24:30] - Patrick's mission to get high quality vitamin K to solve his heart disease [29:45] - Why Patrick thinks that conventional western medicine doesn't routinely test for CAC and other root cause issues [40:00] - A breakdown of Fats, Lipids, hormonal health, and the importance of LDL [57:50] - Brian and Patrick Discuss healthy diet and lifestyle factors [1:20:00] - What to do once your get a CAC score [1:27:45] - The "hydra" of heart disease GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

18 Maj 20221h 40min

Part 158 - Dr. Tyna Moore on The Secrets to Living a Long & Pain-Free Life

Part 158 - Dr. Tyna Moore on The Secrets to Living a Long & Pain-Free Life

11 Maj 20221h 8min

Part 157 - Jessica Thompson, PhD on How Eating Animal Fat & Marrow Made Us Human

Part 157 - Jessica Thompson, PhD on How Eating Animal Fat & Marrow Made Us Human

Specializing in human evolution and the aspects revealed through the analysis of ancient animal bones, Jessica Thomspon is a leading voice in paleo-anthropology, evolutionary theory and hunter-gatherer ethnography. She is a professor at Yale University and also leads the Malawi ancient Lifeways and Peoples Project in Malawi, in central Africa, to develop and interpret the evolutionary history in the area during the last Ice Age. Jessica thompson PhD website: https://campuspress.yale.edu/jcthompson/ The ancestral health & events center in East Austin is getting closer to becoming a reality! Email Brian at hi@foodlies.org to get involved. We're looking for anyone from members to investors! GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org SHOW NOTES: [0:30] - Dr. Jessica speaks about getting back on campus at Yale University and her specialties research in the field of anthropology [5:40] - Jessica's take on where and when we started as a human species [10:10] - What is the difference in diet, structure, etc. between humans and primates split around 7+ million years ago? [16:40] - Diving deep into tool marks on bones and what we can learn from them [24:40] - Jessica shares her opinion on the nuance of why our evolutionary adaptations that make us human occurred [36:10] - Did protein or fat change human evolution? [55:22] - The importance that megafauna played in our evolution and how they played into cooperation and competition in populations [57:05] - Jessica shares her thoughts on adaptations to the type of energy we consume such as milk, fat, etc. as it relates to the genes/skills that get passed down [1:01:00] - The massive shift in our modern diet in the short time frame, causing massive implications in long-term health [1:09:19] - Jessica weighs in on the role of animal products on evolution and our current health [1:17:30] - Jessica's thoughts on longevity and biological anthropology GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Apr 20221h 37min

Part 156 - Keith Norris on Becoming Healthy & Free in Our Crazy Modern World

Part 156 - Keith Norris on Becoming Healthy & Free in Our Crazy Modern World

Keith Norris is an author, speaker, and the founder of Paleo f(x), the world's premier holistic wellness event, covering health, nutrition, spirituality, entrepreneurship and everything in between, which is happening on the 29th of April  through May 1st.    BUY ONE, GET ONE FREE TICKETS   He and his wife also recently wrote a book, Primal Uprising, The Paleo f(x) Guide to Optimizing Your Health, Expanding Your Mind, and Reclaiming Your Freedom Keith and Michelle's book Primal Uprising  Paleo f(x) tickets and teaser video   GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   SHOW NOTES: [0:00] - Brian and Keith catch up and chat about when they first met and Paleo f(x) [10:02] - Keith speaks his mind on living in "bubbles" and the different types that exist in areas, the ideologies that go along with it and Brian's own bubbles [14:40] - Neuro Linguistic Programming - what it is and how to use it for more success [23:15] - Willpower, Nutrient Density, Anthropology and Vegetarianism  [47:30] - Redpilling, Food Guidelines, and Effective thinking  [1:01:00] - Censorship and confronting the establishment by beginning with yourself     GET THE MEAT http://NosetoTail.org FREE SAPIEN FOOD GUIDE http://sapien.org   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

20 Apr 20221h 19min

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