Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases
Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living30 Maj 2019

Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

This is an interview I've been looking forward to for years. Dr. Dale Bredesen is shaking up the medical world by showing that Alzheimer's actually can be prevented, treated, and sometimes even reversed. This is really important to me because my mom is the final stages of Alzherimer's and I, of course, am doing everything I can to prevent myself from falling to the same fate.

I believe the Sapien way of eating and lifestyle is doing just that - setting me up for my best chances at my longest healthspan. You can learn more about this at http://sapien.org/diet

Dr. Bredesen and I agree on all the core principles. He really is describing a Sapien diet with his protocol. We're only at odds with the ratio of plant foods to animal foods.

As I've posted today on social media, I think people are actually more on the side of animal foods than they think. In the context of a whole foods, low carb diet without refined grains, sugar or vegetable oil, more often than not people are getting the majority of their calories from animal foods without necessarily realizing it. Only people eating Standard American Diets or Mediterranean Diets and the like are getting most of their calories from plant foods from all the empty calories coming from grains and other carbohydrates.

Many health figures in this space say things like "a plant heavy diet" or "fill half your plate up with greens" and people take this as being akin to a vegetarian diet. As I showed in my post, a daily intake where about 70% of the plates are filled with plants are actually 92% animal foods by calories.

I actually eat this way a lot. This is carnivore adjacent and is part of the Sapien Framework. You're still getting a ton of flavor, variety, and nutrients from plants (even though they're not as bioavailable), but you're really getting 90% of your calories from animal foods. So make your own decision on the ratio of plant to animal foods, but from what I've found, higher animal foods is more species appropriate for homo sapiens, and is actually what most people avoiding empty calorie, nutrient poor foods are already doing.

As always, I didn't want to press him on this. I don't invite people on my podcast to tell them I don't agree with their opinions. I'd love for this to be debated with a moderator at some point, but as long as it's a 1 on 1 Peak Human podcast I'm letting the guest speak their minds.

Here's a bit of Dr. Bredesen's extensive resume. He received his undergraduate degree from Caltech and his medical degree from Duke. He served as Resident and Chief Resident in Neurology at UCSF, he was the Director of the Easton Center for Alzheimer's Disease Research, he's a Professor in the Department of Molecular and Medical Pharmacology at UCLA School of Medicine, and the Founder of the Buck Institute for Research on Aging.

The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process, and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, leading to the publication of over 220 research papers. He and his group developed a new approach to the treatment of Alzheimer's disease, and this approach led to the discovery of subtypes of the disease, followed by the first description of reversal of symptoms in patients with MCI and Alzheimer's disease, with the ReCODE protocol, published in 2014, 2016, and 2018. His book, The End of Alzheimer's, is a New York Times Bestseller and has been translated into 29 languages.

I'll largely skip the plugs for today. Everyone listening knows about the Food Lies film on Indiegogo, the Patreon at http://patreon.com/peakhuman and my new grass fed meat company http://NoseToTail.org If you find any value in this podcast or my other content on YouTube or social media channels, please consider supporting me and my projects there. I wish I could really get across how much it means to me. It's honestly the only way any of this is possible. Thanks so much, and I'll most likely end season 3 with this episode and come back in a couple weeks with an amazing season 4. Here's the future legend, Dr. Dale Bredesen.

BUY THE MEAT NosetoTail.org

Preorder Food Lies: http://indiegogo.com/projects/food-lies-post

Support me on Patreon! http://patreon.com/peakhuman

SHOW NOTES

  • Dr. Bredesen has been studying the phenomenon of Alzheimer's Disease (AD) for 3 decades and have published over 200 papers on his research
  • Understanding the fundamental nature of the disease is how we can design an effective treatment
  • His protocol is different because it targets the root cause, not the symptoms like most AD drugs do
  • Humans are extremely complicated and there is no one single therapy that will treat the complexity of AD
  • AD is the result of the brain protecting itself from different insults
  • The protective response in the brain causes the brain to shrink and "retreat" so that there is less for foreign substances (insults) to target
  • Amyloids are antimicrobial, bind to toxins, and change the brain's response to glucose but when they are overproduced and build up that's when problems occur
  • Some of the contributors to AD are: chronic inflammation, insulin resistance, glycation damage, toxin exposure, decrease in nutrients, hormones, trophic factors, poor vascular support
  • He has identified and categorized 6 different types of AD: inflammatory, atrophic, glycotoxic, toxic, vascular, and traumatic
  • Paraffin candles produce toxins that damage the brain
  • Most damaging mycotoxins (produced from mold) are the ones you breathe - test your home for molds
  • Go to www.survivingmold.com to learn how to test your home for mold and if you are concerned about mold exposure to learn about what to personally get tested
  • For overall markers you should get tested, you can order tests directly from Dr. Bredesen's site www.drbredesen.com or go to your doctor and test markers
  • Markers for glycotoxicity: fasted insulin, HbA1c, and fasted glucose
  • Markers for nutrients, hormones, and trophic factors: o Vit. D, pragnenolone, progesterone, estradiol, testosterone, free T3 and free T4 (for thyroid), TSH (thyroid stimulating hormone), and reverse T3 (which is an inhibitor of the effect of your active thyroid hormone)
  • Inflammation markers: HS-CRP, TNF-a, IL6, IL8, IL1-b
  • Don't wait until it's too late to check for these things, because AD is preventable
  • Glycotoxicity and how sugar is toxic
  • Humans are not designed to eat sugar
  • Overconsumption of sugar is linked to hypertension, CVD, diabetes, dementia, arthritic, leaky gut, and more
  • Sugar is this generation's smoking, we will get to a day when we think back to how crazy it was that we were eating this stuff
  • We have biomarkers that will tell you whether AD is creeping up on you, so check early in life because you might not feel sick now, but that doesn't mean it's not on its way
  • All these lifestyle and diet changes that you make to prevent AD, apply to so many other modern illnesses
  • If AD runs in your family, you should be interested in prevention
  • AD should be a rare disease
  • APOE4 is the most common genetic risk factor
  • If you have a single copy of APOE4 the risk is ~30%
  • If you have a double copy of APOE4 the risk becomes greater than 50%
  • For people with APOE4, find out early and get on prevention, and you will have a low chance of getting the disease
  • 21st century medicine is about root cause and prevention
  • There is no mono-therapy for AD
  • Look out for symptoms of early cognitive decline like the lack of ability to learn new things, losing organizational skills, not being able to do simple calculations, not being able to find the right word, getting lost in familiar places
  • Don't shake these off as "senior moments"
  • Basic things everyone can do: optimize insulin sensitivity, follow a low-carb, moderate protein, high (good) fat diet, exercise, get enough sleep, reduce stressors in your life, detox, avoid or fix any gut issues, go into periods of ketosis
  • His diet plan is called "KetoFlex 12/3"
  • "Keto" for going into periods of ketosis
  • "Flex" because it is flexitarian, if you want to be a vegetarian or eat meat you can do either
  • "12" because he wants people fasting for at least 12 hours between dinner and the next day's first meal
  • "3" because he wants people to finish eating at least 3 hours before they go to sleep
  • The Big Four to avoid: grains, simple carbs, dairy, and lectins
  • He has had amazing success with his patients and has been publishing results since 2014
  • He has never had someone at risk come in for prevention and develop even mild cognitive impairment (MCI)
  • People who come in with subjected cognitive impairment (SCI) see improvement
  • People who come in with MCI the majority improve
  • People with full-blown AD, some people improve and some people don't
  • He has had people score zero on cognitive tests that have improved
  • The most important point of all of this is that if you get put on a drug for AD you might get a little bump but you fall back to declining again, his approach targets what is actually causing the decline, the people who get better sustain their improvement
  • Complexity gap between the complexity of the problem (human illness) and the data sets that traditional medical doctors are using to treat them (aka we can't expect a simple mono-therapy to treat a complex condition)
  • Dr. Bredesen's daughter is a brain health coach and you can find her at www.siabrainhealth.com
  • His protocol includes sauna for riding the body of toxins
  • We are swimming in an Alzheimer's soup with the amount of toxins we are exposed to in our modern world
  • Get rid of toxins by sweating (sauna and exercise), high fiber diet, optimizing glutathione levels, filtered water, urination, each one of these gets rid of different things
  • If you have leaky gut, fix that
  • The importance of sleep
  • Current research on macular degeneration
  • His new book coming out "The First Survivors of Alzheimer's Disease" will be about people's first-hand stories of people told they had no hope but used his protocol and got better and have kept themselves better
  • The future of medicine will need to look at how humans were evolutionarily designed to live
  • You are not powerless to AD, you have control over it
  • We can reduce the global burden of dementia, we can fight cognitive decline
  • Find Dr. Dale Bredesen at www.drbredesen.com
  • His Facebook page https://facebook.com/drdalebredesen/

BUY THE MEAT NosetoTail.org

Support me on Patreon! http://patreon.com/peakhuman

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Avsnitt(233)

Sapien Podcast - Simplicity, Discipline & Living Fit Past 40 with Chris Kruger

Sapien Podcast - Simplicity, Discipline & Living Fit Past 40 with Chris Kruger

In this episode of Sapien Podcast, Brian Sanders and Chris unpack how to simplify health in a noisy world. They discuss intermittent fasting, the truth about cardio, testosterone, and why building muscle is the foundation for longevity. Chris and Brian share their personal journey, practical tips for busy men, and the philosophy that has helped thousands transform their lives by doing less, but better.   Show Notes: 04:00 The Ten Commandments of Health – Simplicity Over Complexity 07:30 Why Discipline Brings Freedom in Health and Life 10:15 Eating Real Food vs. Diet Dogma 13:40 Intermittent Fasting, Energy, and Recovery 17:20 Muscle as the Anchor of Longevity 20:00 Cardio Myths and Why Strength Training Wins 24:00 Testosterone, Aging, and Building Vitality After 40 28:00 Lifestyle Habits That Compound Over Time 32:00 The Role of Faith, Family, and Community in Health 36:00 Why Simplicity Is the Ultimate Sophistication

4 Nov 35min

Part 229 -Reviving Regenerative Agriculture with Will Harris

Part 229 -Reviving Regenerative Agriculture with Will Harris

Will Harris is known for his pioneering regenerative agriculture practices. The episode explores Harris's journey from traditional farming to regenerative agriculture, the economic challenges, and the impact on land, community, and ecosystems. Harris shares insights from his experiences, including his transition away from chemical-dependent farming and the development of vertically integrated operations. They discuss the benefits of regenerative practices, the difficulties in marketing and scaling, as well as the broader implications for nutrition and sustainability. Lastly, the episode addresses the sustainability of feeding the world through regenerative practices, emphasizing local community support and the long-term generational benefits. 05:10 Introduction to Will Harris 09:05 Challenges and Evolution in Farming Practices 29:43 The Impact of Erosion on Soil Health 30:09 Scientific Comparison: Monocrop vs. Diverse Ecosystem 30:48 Economic Challenges of Transitioning to Regenerative Farming 31:49 The Rise of Grass-Fed Beef and Market Challenges 33:00 Educating Consumers on Grass-Fed Beef 35:03 The Influence of Propaganda on Food Choices 42:18 The Role of Debt in Farm Management 44:15 Challenges in Poultry Farming 50:31 The Benefits of Regenerative Agriculture 53:31 Feeding the World Sustainably 01:00:20 Reflections on the Future of Regenerative Farming BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Okt 1h 2min

Sapien Podcast- Fiber Myths, Vitamin C Lies, and the Fight for Root-Cause Health with Chris Kruger

Sapien Podcast- Fiber Myths, Vitamin C Lies, and the Fight for Root-Cause Health with Chris Kruger

In this episode of the Sapien Podcast, Chris Kruger returns as co-host with Brian Sanders for a deep dive into nutrition myths, fiber fallacies, and the failures of mainstream dietetics. Together, they expose how official guidelines and academic institutions push confusion for profit while ignoring root-cause solutions. The hosts critique health narratives around fiber, red meat, vitamin C, and weight-loss drugs, while sharing client case studies that reveal the real path to metabolic health. They emphasize the Sapien approach: whole foods, animal-based nutrition, hormone balance, and lifestyle over pills and procedures. SHOW NOTES: 04:00 The Football Analogy: nutritionists misunderstand cause and effect 06:00 Debunking fiber myths and why whole foods matter most 09:00 Case study: reversing lifelong constipation with a low-fiber diet 12:00 Red meat, healthy user bias, and flawed nutrition studies 14:30 Academia, food industry funding, and distorted guidelines 15:30 Carnivore diets and the vitamin C myth 18:00 Beyond "calories in, calories out" 27:00 Defining metabolic syndrome vs. metabolic excellence 30:00 Statins, side effects, and why lifestyle beats prescriptions 32:00 Hormone health as the foundation of motivation and vitality BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Okt 37min

Sapien Podcast- Fitness Wisdom Unplugged

Sapien Podcast- Fitness Wisdom Unplugged

In this episode of the Sapien Podcast, Chris Krueger joins the show as a new co-host along with host Brian Sanders. They introduce the podcast as a fun, unplanned discussion about health, fitness, and hormone optimization. The hosts share personal fitness stories and emphasize the importance of a holistic approach to health, advocating for living naturally and avoiding artificial supplementation like TRT. They critique Brian Johnson's extreme health regimens and promote practical, actionable steps for achieving and maintaining elite health without extensive gym workouts or complex diet plans. SHOW NOTES: 00:00 Introduction to the Sapien Podcast 01:11 Fitness and Hormone Optimization 01:25 Generational Fitness and Relatability 01:43 Chris's Fitness Feats and Midlife Reflections 04:57 The Importance of Staying Active 05:38 Family Dynamics and Health Advice 08:01 The Sapien Lifestyle and Hormone Balance 14:16 Insulin and Metabolic Health 17:31 Raw Milk and Sapien Center Community 18:42 Farmer's Market Raw Milk Prices 20:43 Brian Johnson's Cult-Like Brunch 22:03 The Profit in Food Processing 25:31 Debunking Diet Myths   BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

22 Okt 35min

Part 228 - Dr. Doug McGuff on High-Intensity Training, Recovery, and the Truth About Nutrition

Part 228 - Dr. Doug McGuff on High-Intensity Training, Recovery, and the Truth About Nutrition

Dr. Doug McGuff is an emergency physician, exercise researcher, and co-author of Body by Science. Known for his pioneering work in high-intensity resistance training, McGuff blends decades of medical practice with deep knowledge of physiology to reveal how short, focused workouts can yield extraordinary health benefits. He also runs training studios in South Carolina that specialize in safe, supervised strength training. In this episode of Peak Human, Brian Sanders and Dr. McGuff dive into why most people misunderstand exercise, the dangers of overtraining, and how nutrition and movement fit together for long-term health. They cover everything from the "12-minute workout" to the role of myokines, why VO₂ max is misunderstood, and how subsidies and processed foods hijacked the human diet. This conversation reframes what it truly means to build strength, resilience, and health for life. Show Notes: 03:00 Dr. McGuff's Background: Emergency Medicine & Strength Training 07:00 Adaptive Resistance Training (ARX) & How It Works 14:00 The Physiology of Strength: Motor Units & True Failure 22:00 The "12-Minute Workout" – Time Efficiency & Maximum Results 25:00 Overtraining, PEDs, and the Myths of Modern Fitness Culture 28:00 Long-Term Damage from Inefficient Training Methods 30:00 You Can't Out-Exercise a Bad Diet 33:00 The Straight Line Between You and the Sun – Whole Food Nutrition 44:00 Debunking the Meat & Gout Myth 48:00 Eat Densely, Move Intensely – Rethinking Fitness Advice 49:00 Cardio Myths, VO₂ Max, and the Zone 2 Obsession 56:00 What Really Correlates With Longevity: Adaptation, Not Numbers BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Sep 1h 14min

Part 227 - Holistic Health, Slow Food, and Lifelong Vitality with Tara Couture

Part 227 - Holistic Health, Slow Food, and Lifelong Vitality with Tara Couture

In this episode of Peak Human, host Brian Sanders welcomes back Tara Couture. Tara, a renowned advocate for the Sapien lifestyle, shares insights into her holistic approach to health, which includes growing her own food and embracing a nutrient-dense diet. The discussion covers various topics, including nutrition, lifestyle factors, nature, hormone optimization for both men and women, and practical tips for adopting this lifestyle even in urban settings. Tara also discusses her new book, 'Radiance of the Ordinary,' which explores the profound rewards of living authentically and nourishing one's body. Brian also highlights the benefits of natural supplements like oyster pills for hormone optimization. A must-listen for anyone interested in sustainable living and holistic health. Show Notes: 00:15 Tara's Lifestyle and Farmstead 00:59 Nutrition and Lifestyle 07:46 Raising Healthy Children 15:36 Cooking and Food Preparation 31:45 Travel and Eating Healthy 35:10 Carbs and Diet Adjustments 36:42 Exploring the Benefits of Carbs 38:00 Introducing Tara's Book: Radiance of the Ordinary 38:46 The Dichotomies of Life and Embracing Mortality 43:33 The Importance of Real Food and Nutrition 48:13 Men's Health and Hormones 57:41 The Simplicity of Whole Foods 01:05:54 The Gift of a Healthy Body BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Tara's Book: https://www.penguinrandomhouse.com/books/798098/radiance-of-the-ordinary-by-tara-couture/ Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

3 Sep 1h 12min

Part 226 - Biohacking and Homesteading: Bridging the Gap with Michael Kummer

Part 226 - Biohacking and Homesteading: Bridging the Gap with Michael Kummer

In this episode, Brian Sanders chats with Michael Kummer about his multifaceted approach to health and wellness, which combines elements of biohacking, fitness, and homesteading. Kummer, a proponent of the 'Sapien' philosophy, emphasizes a diet and lifestyle that closely mimic natural human behaviors. The discussion covers Michael's fitness routine, which involves minimal gym time, his creation of an accessible fitness program, and his unique perspective on the synergy between biohacking and homesteading. They delve into the issue of modern diets, stress, and lifestyle factors impacting health, using Austria as a case study to highlight these trends. Kummer also shares insights into his family's transition to a homesteading lifestyle and offers practical tips for integrating these principles into various lifestyles.   Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show Notes: 02:18 Biohacking vs. Natural Living 04:12 Homesteading and Food Production 08:45 Health Impacts of Modern Lifestyle 12:03 Traditional Food Preparation Techniques 24:41 The Importance of Muscle Mass 28:12 Austrian Lifestyle and Longevity 33:02 Traditional Austrian Diet: Then and Now 33:16 Impact of World War II on Diet and Lifestyle 35:32 Modern Austrian Diet and Health Trends 37:46 Comparing Health Outcomes: Austria vs. USA 45:38 Personal Fat Threshold and Its Implications 51:52 Homesteading and Sustainable Living 54:21 Balancing Modern Life with Traditional Practices 58:21 The Role of Community in Homesteading 01:03:13 Supplements and Whole Foods for Optimal Health   BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

13 Aug 1h 6min

Part 225 - Unlocking the Secrets of Satiety Per Calorie with Dr. Ted Naiman

Part 225 - Unlocking the Secrets of Satiety Per Calorie with Dr. Ted Naiman

In this episode of Peak Human, host Brian Sanders interviews Dr. Ted Naiman, discussing the concept of satiety per calorie and its implications for diet and health. They dive into the importance of understanding different diet patterns, focusing on high-protein, nutrient-dense foods, and avoiding overly processed foods. The conversation covers the four pillars of satiety per calorie: protein percentage, energy density, fiber content, and hedonics. Dr. Naman also talks about his new book 'Satiety Per Calorie,' which aims to provide a comprehensive understanding of diet and nutrition, helping people make informed food choices to maintain optimal body composition effortlessly. The episode concludes with discussions on the benefits of natural exercise routines and natural supplements for overall health.   Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show notes   00:28 Understanding Diets and Nutrition 01:28 Exercise and Fitness Insights 02:09 Oyster Pills and Testosterone Boost 03:15 Daily Life and Health Philosophy 03:53 Satiety and Nutrient Density 05:38 The PE Diet and Satiety Per Calorie 06:34 Explaining Diet Patterns and Health Outcomes 12:48 Practical Tips for Diet and Exercise 41:09 Understanding Protein Leverage and Obesity 44:07 Can You Get Fat on Protein? 45:47 Nutrient Calories vs. Energy Calories 49:33 The Four Pillars of Satiety Per Calorie 54:42 The Role of Fiber in Satiety 01:01:38 Energy Density and Caloric Intake 01:07:01 The Liver's Role in Metabolism   REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

6 Aug 1h 14min

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