Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases
Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living30 Maj 2019

Part 43 - Dr. Dale Bredesen and the End of Alzheimer's, How YOU Can Prevent it, and Hope for All Degenerative Diseases

This is an interview I've been looking forward to for years. Dr. Dale Bredesen is shaking up the medical world by showing that Alzheimer's actually can be prevented, treated, and sometimes even reversed. This is really important to me because my mom is the final stages of Alzherimer's and I, of course, am doing everything I can to prevent myself from falling to the same fate.

I believe the Sapien way of eating and lifestyle is doing just that - setting me up for my best chances at my longest healthspan. You can learn more about this at http://sapien.org/diet

Dr. Bredesen and I agree on all the core principles. He really is describing a Sapien diet with his protocol. We're only at odds with the ratio of plant foods to animal foods.

As I've posted today on social media, I think people are actually more on the side of animal foods than they think. In the context of a whole foods, low carb diet without refined grains, sugar or vegetable oil, more often than not people are getting the majority of their calories from animal foods without necessarily realizing it. Only people eating Standard American Diets or Mediterranean Diets and the like are getting most of their calories from plant foods from all the empty calories coming from grains and other carbohydrates.

Many health figures in this space say things like "a plant heavy diet" or "fill half your plate up with greens" and people take this as being akin to a vegetarian diet. As I showed in my post, a daily intake where about 70% of the plates are filled with plants are actually 92% animal foods by calories.

I actually eat this way a lot. This is carnivore adjacent and is part of the Sapien Framework. You're still getting a ton of flavor, variety, and nutrients from plants (even though they're not as bioavailable), but you're really getting 90% of your calories from animal foods. So make your own decision on the ratio of plant to animal foods, but from what I've found, higher animal foods is more species appropriate for homo sapiens, and is actually what most people avoiding empty calorie, nutrient poor foods are already doing.

As always, I didn't want to press him on this. I don't invite people on my podcast to tell them I don't agree with their opinions. I'd love for this to be debated with a moderator at some point, but as long as it's a 1 on 1 Peak Human podcast I'm letting the guest speak their minds.

Here's a bit of Dr. Bredesen's extensive resume. He received his undergraduate degree from Caltech and his medical degree from Duke. He served as Resident and Chief Resident in Neurology at UCSF, he was the Director of the Easton Center for Alzheimer's Disease Research, he's a Professor in the Department of Molecular and Medical Pharmacology at UCLA School of Medicine, and the Founder of the Buck Institute for Research on Aging.

The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process, and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, leading to the publication of over 220 research papers. He and his group developed a new approach to the treatment of Alzheimer's disease, and this approach led to the discovery of subtypes of the disease, followed by the first description of reversal of symptoms in patients with MCI and Alzheimer's disease, with the ReCODE protocol, published in 2014, 2016, and 2018. His book, The End of Alzheimer's, is a New York Times Bestseller and has been translated into 29 languages.

I'll largely skip the plugs for today. Everyone listening knows about the Food Lies film on Indiegogo, the Patreon at http://patreon.com/peakhuman and my new grass fed meat company http://NoseToTail.org If you find any value in this podcast or my other content on YouTube or social media channels, please consider supporting me and my projects there. I wish I could really get across how much it means to me. It's honestly the only way any of this is possible. Thanks so much, and I'll most likely end season 3 with this episode and come back in a couple weeks with an amazing season 4. Here's the future legend, Dr. Dale Bredesen.

BUY THE MEAT NosetoTail.org

Preorder Food Lies: http://indiegogo.com/projects/food-lies-post

Support me on Patreon! http://patreon.com/peakhuman

SHOW NOTES

  • Dr. Bredesen has been studying the phenomenon of Alzheimer's Disease (AD) for 3 decades and have published over 200 papers on his research
  • Understanding the fundamental nature of the disease is how we can design an effective treatment
  • His protocol is different because it targets the root cause, not the symptoms like most AD drugs do
  • Humans are extremely complicated and there is no one single therapy that will treat the complexity of AD
  • AD is the result of the brain protecting itself from different insults
  • The protective response in the brain causes the brain to shrink and "retreat" so that there is less for foreign substances (insults) to target
  • Amyloids are antimicrobial, bind to toxins, and change the brain's response to glucose but when they are overproduced and build up that's when problems occur
  • Some of the contributors to AD are: chronic inflammation, insulin resistance, glycation damage, toxin exposure, decrease in nutrients, hormones, trophic factors, poor vascular support
  • He has identified and categorized 6 different types of AD: inflammatory, atrophic, glycotoxic, toxic, vascular, and traumatic
  • Paraffin candles produce toxins that damage the brain
  • Most damaging mycotoxins (produced from mold) are the ones you breathe - test your home for molds
  • Go to www.survivingmold.com to learn how to test your home for mold and if you are concerned about mold exposure to learn about what to personally get tested
  • For overall markers you should get tested, you can order tests directly from Dr. Bredesen's site www.drbredesen.com or go to your doctor and test markers
  • Markers for glycotoxicity: fasted insulin, HbA1c, and fasted glucose
  • Markers for nutrients, hormones, and trophic factors: o Vit. D, pragnenolone, progesterone, estradiol, testosterone, free T3 and free T4 (for thyroid), TSH (thyroid stimulating hormone), and reverse T3 (which is an inhibitor of the effect of your active thyroid hormone)
  • Inflammation markers: HS-CRP, TNF-a, IL6, IL8, IL1-b
  • Don't wait until it's too late to check for these things, because AD is preventable
  • Glycotoxicity and how sugar is toxic
  • Humans are not designed to eat sugar
  • Overconsumption of sugar is linked to hypertension, CVD, diabetes, dementia, arthritic, leaky gut, and more
  • Sugar is this generation's smoking, we will get to a day when we think back to how crazy it was that we were eating this stuff
  • We have biomarkers that will tell you whether AD is creeping up on you, so check early in life because you might not feel sick now, but that doesn't mean it's not on its way
  • All these lifestyle and diet changes that you make to prevent AD, apply to so many other modern illnesses
  • If AD runs in your family, you should be interested in prevention
  • AD should be a rare disease
  • APOE4 is the most common genetic risk factor
  • If you have a single copy of APOE4 the risk is ~30%
  • If you have a double copy of APOE4 the risk becomes greater than 50%
  • For people with APOE4, find out early and get on prevention, and you will have a low chance of getting the disease
  • 21st century medicine is about root cause and prevention
  • There is no mono-therapy for AD
  • Look out for symptoms of early cognitive decline like the lack of ability to learn new things, losing organizational skills, not being able to do simple calculations, not being able to find the right word, getting lost in familiar places
  • Don't shake these off as "senior moments"
  • Basic things everyone can do: optimize insulin sensitivity, follow a low-carb, moderate protein, high (good) fat diet, exercise, get enough sleep, reduce stressors in your life, detox, avoid or fix any gut issues, go into periods of ketosis
  • His diet plan is called "KetoFlex 12/3"
  • "Keto" for going into periods of ketosis
  • "Flex" because it is flexitarian, if you want to be a vegetarian or eat meat you can do either
  • "12" because he wants people fasting for at least 12 hours between dinner and the next day's first meal
  • "3" because he wants people to finish eating at least 3 hours before they go to sleep
  • The Big Four to avoid: grains, simple carbs, dairy, and lectins
  • He has had amazing success with his patients and has been publishing results since 2014
  • He has never had someone at risk come in for prevention and develop even mild cognitive impairment (MCI)
  • People who come in with subjected cognitive impairment (SCI) see improvement
  • People who come in with MCI the majority improve
  • People with full-blown AD, some people improve and some people don't
  • He has had people score zero on cognitive tests that have improved
  • The most important point of all of this is that if you get put on a drug for AD you might get a little bump but you fall back to declining again, his approach targets what is actually causing the decline, the people who get better sustain their improvement
  • Complexity gap between the complexity of the problem (human illness) and the data sets that traditional medical doctors are using to treat them (aka we can't expect a simple mono-therapy to treat a complex condition)
  • Dr. Bredesen's daughter is a brain health coach and you can find her at www.siabrainhealth.com
  • His protocol includes sauna for riding the body of toxins
  • We are swimming in an Alzheimer's soup with the amount of toxins we are exposed to in our modern world
  • Get rid of toxins by sweating (sauna and exercise), high fiber diet, optimizing glutathione levels, filtered water, urination, each one of these gets rid of different things
  • If you have leaky gut, fix that
  • The importance of sleep
  • Current research on macular degeneration
  • His new book coming out "The First Survivors of Alzheimer's Disease" will be about people's first-hand stories of people told they had no hope but used his protocol and got better and have kept themselves better
  • The future of medicine will need to look at how humans were evolutionarily designed to live
  • You are not powerless to AD, you have control over it
  • We can reduce the global burden of dementia, we can fight cognitive decline
  • Find Dr. Dale Bredesen at www.drbredesen.com
  • His Facebook page https://facebook.com/drdalebredesen/

BUY THE MEAT NosetoTail.org

Support me on Patreon! http://patreon.com/peakhuman

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Avsnitt(233)

Part 217 - Stephan van Vliet on the Hidden Health Benefits of Red Meat

Part 217 - Stephan van Vliet on the Hidden Health Benefits of Red Meat

Stephan van Vliet, PhD, is a distinguished researcher specializing in nutritional metabolomics at the Center for Human Nutrition Studies at Utah State University. He is widely recognized for his groundbreaking work in identifying and analyzing over 50,000 bioactive secondary compounds in meat. Dr. van Vliet's research emphasizes the nutritional and environmental implications of these compounds, particularly their roles in human health and disease prevention. His work challenges conventional dietary recommendations by highlighting the complex nutrient profile of meat and its potential benefits beyond primary nutrients. His contributions to the field have been published in numerous esteemed scientific journals, making significant impacts on our understanding of diet and health.   SHOW NOTES   01:10 Introduction to the Center for Human Nutrition Studies 02:07 Exploring Nutrition Studies and Grass-Fed Beef Research 03:03 Collaborations and Mentorship in Nutrition Science 04:46 The Impact of Diet on Human Health: A Deep Dive 18:40 The Complexity of Food and Its Nutritional Value 36:53 Regenerative Agriculture and Its Economic Implications 42:47 Debunking Processed Meat Myths 43:43 The Surprising Health Benefits of Traditional Meats 47:30 Nutrient Density and Satiety: The Protein Leverage Hypothesis 48:44 Exploring the World of Secondary Compounds 52:21 The Power of Whole Foods: Simple Yet Effective 54:32 Personalizing Nutrition: One Size Does Not Fit All 01:10:31 The Height and Health Connection: A Global Perspective 01:14:41 Regenerative Agriculture: Beyond the Hype 01:21:52 Concluding Thoughts: Accessibility and Health

9 Maj 20241h 17min

Part 216 - Mollie Englehart Makes All Her Vegan Restaurants Animal Based

Part 216 - Mollie Englehart Makes All Her Vegan Restaurants Animal Based

In this enlightening episode, we dive deep into Mollie Engelhart's transformative journey from a lifelong vegan upbringing to embracing regenerative agriculture and modifying her Los Angeles restaurant, Sage Bistro, to incorporate regenerative meat. Engelhart shares her compelling story, backed by her experience as both a regenerative farmer and a vegan chef, highlighting the environmental, nutritional, and ethical considerations that led to her pivotal shift. This discussion not only sheds light on the practical aspects of sustainable farming and the impact of dietary choices on personal health and the environment but also illustrates Engelhart's commitment to nutrient-dense food production and her vision for the future of sustainable dining.   REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   SHOW NOTES 02:33 Molly Engelhardt's Big Announcement: A Vegan Restaurateur's Shift to Regenerative Practices 04:11 The Realities of Veganism and the Importance of Animal Nutrition 14:58 Molly's Personal Journey: From Veganism to Regenerative Farming 22:29 Raising a Family on a Regenerative Farm: Diverse Diets and Health Insights 22:49 Adopting a Regenerative Lifestyle: Osmar's Story 28:36 Navigating Beliefs and Changing Perspectives: A Conversation on Food, Health, and Society 34:16 Celebrating Earth Day with Regenerative Agriculture 34:21 The Common Ground of Soil Health 35:30 The Impact of Big Ag and Big Pharma on Agriculture 36:13 The Harsh Realities of Monocropping 38:07 Embracing Regenerative Farming Practices 44:41 The Journey from Veganism to Regenerative Agriculture 44:42 Traditional Diets and Dental Health 57:07 The Dangers of Processed Foods and the Benefits of Whole Foods 01:05:17 Fermentation: Unlocking Nutritional Value in Indigenous Diets 01:06:40 Reflecting on Modern Diets and the Genius of Human Adaptation 01:07:44 Announcing the New Regenerative Kitchen Concept   REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Apr 20241h 8min

Part 215 - Jason Karp on How to Cure Incurable Diseases with Diet

Part 215 - Jason Karp on How to Cure Incurable Diseases with Diet

This podcast episode, featuring host Brian Sanders and entrepreneur Jason Karp, delves into Jason's personal health journey of overcoming incurable blindness through dietary changes. It critically examines the negative impacts of the industrial food system on both human health and the environment, spotlighting deceptive practices by major food corporations like Kellogg's. The conversation advocates for a shift towards consuming less processed foods, supporting regenerative agriculture, and making informed food choices for sustainable living.   REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   SHOW NOTES 00:00 Welcome to Peak Human & Introduction to Jason Karp's Journey 02:47 Jason Karp's Health Transformation Through Diet 09:04 The Sapien Thesis: Unveiling the Metacrisis of Modern Society 22:11 The Power of Nature and Ancestral Wisdom in Healing 30:14 Challenging Modern Food Systems and Embracing Regenerative Agriculture 34:38 The Importance of Community, Love, and Returning to Human Fundamentals 38:02 Rediscovering Human Roots for Happiness 38:36 Aligning with Nature in Modern Society 40:14 The Journey from Cyborg to Balanced Human 40:39 Leveraging vs. Aligning with Nature 41:29 Creating Healthier Food Alternatives 43:40 Human Co: Revolutionizing Food with Health in Mind 46:55 The Power of Regenerative Farming 48:40 Challenging the Ultra-Processed Food Paradigm 56:03 The Economics of Healthy Eating 01:03:22 Taking Action Against Unhealthy Food Practices 01:09:59 Personal Health Miracles Through Diet   BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

18 Apr 20241h 12min

Part 214 - You Can't Cheat Nature

Part 214 - You Can't Cheat Nature

Drako, an international entrepreneur, nutrition advocate and partner at Nose to Tail, champions a diet centered on whole natural foods, emphasizing their crucial role in optimal health. He is the co-founder of the Sapien Center and the Sapien Movement, a community organization focused on human health and thriving. After solving multiple chronic health conditions through nutrition and lifestyle methods, he now promotes the use of nutrient-dense foods to combat chronic diseases and insulin resistance. Beyond the health sector, Drako has made significant strides in the financial world as CEO of the African fintech company Kuva.com. His diverse expertise reflects a commitment to enhancing human health and wealth in the modern world. Get on the waitlist for the Sapien Community Organization Sapien.org BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (05:16) One of the keys to longevity among those living in "Blue Zones" are their tight-knit communities and strong sense of personal identity, more than just their nutrition. (11:27) Longevity is not just the amount of years you live, but the quality of experiences and that throughline of purpose in your life. (20:59) Avoid eating plants with vigor-altering chemicals, which become gut irritants that poison the body over time. Such chemicals exist as a defense mechanism to prevent the over-eating of these plants. (29:48) Whatever is in your body is there for a reason, in accordance with nature. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

11 Apr 202447min

Part 213 - Escape the Matrix of Modern Society

Part 213 - Escape the Matrix of Modern Society

Drako, an international entrepreneur, nutrition advocate and partner at Nose to Tail, champions a diet centered on whole natural foods, emphasizing their crucial role in optimal health. He is the co-founder of the Sapien Center and the Sapien Movement, a community organization focused on human health and thriving. After solving multiple chronic health conditions through nutrition and lifestyle methods, he now promotes the use of nutrient-dense foods to combat chronic diseases and insulin resistance. Beyond the health sector, Drako has made significant strides in the financial world as CEO of the African fintech company Kuva.com. His diverse expertise reflects a commitment to enhancing human health and wealth in the modern world. Sapien.org BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (06:16) Commercial food is not necessarily healthy food. (17:03) The Haber–Bosch process has resulted in a population explosion, but our current food supply now depends on synthetic resources to sustain itself as a result. (30:33) You can't cheat nature. (36:06) When you prioritize energy-dense foods over nutrient-dense foods, your body will be left starving for more even as it gets fatter and sicker. (46:50) What serves the structure does not serve the individual. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

28 Mars 20241h 4min

Part 212 - Dr. Ted Naiman & Dr. Andreas Eenfeldt on How to Not Overeat

Part 212 - Dr. Ted Naiman & Dr. Andreas Eenfeldt on How to Not Overeat

Dr. Ted Naiman is a distinguished physician recognized for his contributions to the field of health and wellness. With a background in family medicine and bariatric medicine, Dr. Naiman has built a reputation for his innovative patient care approaches, focusing on lifestyle interventions for chronic disease management. He is the author of several influential publications and a sought-after speaker at health conferences worldwide. His groundbreaking work in nutritional health has positioned him as a key thought leader in the medical community. http://tednaiman.com Dr. Andreas Eenfeldt is a highly esteemed medical professional and a pioneer in the digital health space. He has garnered widespread acclaim for his work in simplifying complex medical concepts for the general public, particularly through his influential health website. Dr. Eenfeldt's commitment to patient education and empowerment has made a significant impact, evidenced by the large online community he has built. As a speaker and author, he continues to contribute to important discussions on health and wellness, inspiring a global audience. http://dietdoctor.com and  Their new project: http://hava.co

20 Mars 20241h 8min

Part 211 - The #1 Trick To Not Get Fat - From Acclaimed Scientists Raubenheimer & Simpson

Part 211 - The #1 Trick To Not Get Fat - From Acclaimed Scientists Raubenheimer & Simpson

Dr. Stephen J. Simpson and Dr. David Raubenheimer are renowned scientists known for their work in the field of nutritional ecology. Their research primarily focuses on understanding how organisms, including humans, regulate their intake of nutrients and how this affects their health and behavior. Dr. Stephen Simpson is an Academic Director of the Charles Perkins Centre and a Professor in the School of Life and Environmental Sciences at the University of Sydney. His research has spanned several disciplines, from studying locusts to human obesity, and he has been influential in developing the field of nutritional ecology. Dr. David Raubenheimer, also affiliated with the University of Sydney, holds the Leonard P. Ullmann Chair in Nutritional Ecology. His research involves the study of nutrition and its effects across a wide range of species, including humans. He has worked extensively on the concept of nutritional geometry, which is a framework for understanding how animals and humans make decisions about what and how much to eat. Together, Simpson and Raubenheimer developed the "Protein Leverage Hypothesis," which suggests that the protein content of the diet can strongly influence total energy intake and thus has significant implications for understanding obesity. Their collaborative work has been pivotal in highlighting the complex interactions between diet composition, appetite, and health, making significant contributions to both basic biology and implications for human health and nutrition. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (08:00) Every species studied in their natural, undisturbed environments thrive in their nutritional balance. (16:32) The protein leverage hypothesis (see study: https://pubmed.ncbi.nlm.nih.gov/22022472/#:~:text=The%20'protein%20leverage%20hypothesis'%20proposes,promote%20the%20development%20of%20obesity.) posits that we have a preference for protein over other macronutrients, and that the amount of protein we consume influences our appetite for carbs and fats afterwards. (28:07) Eating more, per se, isn't the problem. It's when that food is higher in energy density than fiber that leads to overeating and, by extension, obesity. (38:58) Much of the fruit we eat is not entirely natural due to the modification they go through in farms. (46:02) Over time, our bodies have adapted to thrive in the environment in which human beings find themselves. Today, we continue to adapt, but not necessarily for the better. (54:18) Even our circadian biology has been shaken up through modern sleep patterns and our supplementation with sleep pills and caffeine. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

6 Mars 202458min

Part 210 - Nora Gedgaudas on Animal-Based Diets & Eating Off the Ground For Health

Part 210 - Nora Gedgaudas on Animal-Based Diets & Eating Off the Ground For Health

Nora Gedgaudas is a renowned nutritionist and author, recognized for her expertise in the Paleo diet and ancestral health. She advocates for a nutrient-dense diet, emphasizing the importance of whole foods, healthy fats, and proteins for optimal health and well-being. Nora's work blends modern nutritional science with evolutionary biology, offering a unique perspective on diet and wellness. She is a sought-after speaker and consultant, inspiring individuals to adopt lifestyle changes for long-term health benefits. Discover more about her philosophy and access a wealth of resources at her website: www.noragedgaudas.com.

6 Dec 20231h 9min

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