Digital Twins: The End of Human Drug Testing for Biohackers  : 1342

Digital Twins: The End of Human Drug Testing for Biohackers : 1342

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he’s a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension.


Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today’s standards. You’ll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life.


You’ll Learn:

• How digital twins will end human drug testing

• Why AGI could replace doctors and computer jobs within five years

• How AI models immune function, metabolism, and aging

• The role of mitochondria and inflammation in longevity

• How GLP-1 drugs and metformin extend lifespan

• What continuous biological monitoring means for health tracking

• How AI is transforming functional medicine and personalized care

• Why NAD and energy metabolism are key to human performance


They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You’ll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan.


This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation.


This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You’ll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder


Thank you to our sponsors!


Resources:

• Keep up with Derya’s work: https://x.com/derya_?lang=en

• Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 — Trailer

01:25 — Intro

02:26 — AI’s Role in Extending Lifespan

02:56 — Regulatory Frameworks and Medical Adoption

05:19 — Problems with the Immune System

08:19 — Chronic Fatigue and Long COVID Research

10:32 — Modern Testing and Multi-Omic Analysis

14:07 — Personal Longevity Strategy and Supplements

15:17 — Understanding Exhausted Cells

23:43 — Personalization in Medicine and AI Analysis

31:35 — Longevity Escape Velocity

36:13 — AI Doctors and Prescriptions

39:55 — Data Quality Concerns in AI Training

43:19 — The Future of Wearable Technology

45:50 — Revolutionizing Education with AI

49:04 — The Future of Higher Education

52:03 — Future of Work and AI Agents

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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The Ultimate Guide to a Metabolism That Burns Fat Again  — with Ben Azadi : 1295

The Ultimate Guide to a Metabolism That Burns Fat Again — with Ben Azadi : 1295

93% of people are metabolically unhealthy, and it’s not because they’re lazy or eating too much fat. It’s because their bodies forgot how to burn fat at all. This episode gives you a complete roadmap to reboot your metabolism, escape the sugar-burning trap, and reignite your fat-burning engine for good. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Ben Azadi, functional health expert, best-selling author of Metabolic Freedom, and one of today’s most trusted voices in the ketogenic and fasting space. After reversing his own obesity through biohacking and functional medicine, Ben has helped millions unlock metabolic flexibility and master human performance through smarter-not-harder strategies. They explore how high insulin, not fat or salt, drives most chronic disease, and why your doctor probably isn’t testing for it. You’ll learn the truth about seed oils, fructose, and blood sugar spikes, and why most people using continuous glucose monitors are still missing the real metabolic threat. You’ll also discover how to: • Switch out of sugar-burning mode and back into fat-burning ketosis • Use fasting, cold therapy, and sleep optimization to repair mitochondrial damage • Fix hidden nutrient deficiencies with the right supplements, potassium, and electrolytes • Build real metabolic resilience with Danger Coffee, functional medicine, and nootropics • Avoid the trap of endless keto or carnivore and learn how to cycle your way to true metabolic freedom • Understand why low HRV, high insulin, and sleep debt crush longevity, energy, and brain optimization • Decode how neuroplasticity, emotional regulation, and resilience all connect to metabolism This is your science-backed guide to transforming your energy, losing stubborn fat, and becoming metabolically unstoppable. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. - IGNITON | Go to https://www.igniton.com/DAVE and use code DAVE to save 15%. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Ben’s New Book - Metabolic Freedom: A 30-Day Guide to Restore Your Metabolism, Heal Hormones & Burn Fat: https://www.amazon.com/Metabolic-Freedom-Restore-Metabolism-Hormones/dp/1401994369 • Ben’s Instagram: https://www.instagram.com/thebenazadi/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:04 Intro • 02:42 Insulin Explained • 06:00 Salt vs. Potassium • 08:10 Uric Acid & Fructose • 12:56 Health Trolls • 18:14 Seed Oil Truth • 24:24 Cooking Oil Breakdown • 31:08 Carnivore & Flexibility • 34:57 Gut Test Insights • 36:09 Cholesterol Panel • 36:43 LMHR Explained • 37:39 Inflammation Markers • 40:25 Managing Autoimmunity • 42:07 Gut Bacteria & Fiber • 46:55 Fasting for Gut Health • 48:03 Saturated Fat & Gut • 49:34 Oxalates & Diet • 57:32 Metabolic Efficiency • 01:03:08 Hormesis & Stress • 01:08:21 Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Juni 1h 6min

Why Your Workouts Aren’t Giving You a Summer Body — with Nick Bare  : 1294

Why Your Workouts Aren’t Giving You a Summer Body — with Nick Bare : 1294

You’re working out, eating clean, and still not getting the results you want. This episode reveals the real reason your fitness isn’t translating to the summer body you’re chasing and what to do instead. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with performance-driven entrepreneur and former Army Ranger Nick Bare, founder of Bare Performance Nutrition and the Go One More movement. With over a decade of experience in human performance, endurance, and mindset training, Nick has built a cult-like following by pushing the limits of physical and mental resilience without burning out. In this episode, you’ll learn why consistency beats intensity, how to spot the traps of overtraining, and how to train smarter by understanding mitochondria function, recovery science, and sleep optimization. Dave and Nick go deep on longevity tactics, cold therapy, neurohacking rituals, and why emotional regulation is the missing link in high performance. They also break down elite strategies for entrepreneurial stress, parenting under pressure, and how to balance ambition with recovery using tools from biohacking, self-quantification, and functional medicine. You’ll get practical insights into how Upgrade Labs, Danger Coffee, and the principles behind Smarter Not Harder can dramatically boost your energy and focus. Whether you’re an endurance athlete, a sleep-deprived parent, or a business builder trying to avoid burnout, this conversation gives you the blueprint for sustainable energy, powerful willpower, and next-level fitness that actually works. You’ll Learn: • The true cost of overtraining and how to avoid it • How to create “sprints” in life without sacrificing long-term performance • Tactical upgrades for training, sleep, fasting, and emotional recovery • What most people get wrong about motivation and discipline • How to use nootropics, cold therapy, and fasting to accelerate growth • Why fear of mediocrity can be fuel if used correctly • How testosterone, cortisol, and dopamine affect parenting, performance, and purpose Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order -Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Nick’s Website – https://www.nickbare.com/ • Nick’s Instagram: https://www.instagram.com/nickbarefitness/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:55 Intro • 02:59 Longevity & health • 07:51 Endurance vs recovery • 20:23 Focus & boundaries • 23:16 Pain & recovery • 24:48 Dopamine & motivation • 25:48 Breath work & states • 28:24 Endurance as meditation • 30:44 Curiosity & fear • 32:22 Purposeful suffering • 33:33 Vision quests • 40:18 Nervous system switching • 45:59 Decision-making • 47:59 Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Juni 49min

The Plants That Reverse Aging And Block Daily Toxins — with Darin Olien : 1293

The Plants That Reverse Aging And Block Daily Toxins — with Darin Olien : 1293

Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You’ll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking from two experts who’ve spent decades researching how to upgrade the human body. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Darin Olien, environmental health expert, bestselling author of Fatal Conveniences, and co-host of the Netflix series Down to Earth with Zac Efron. Darin has traveled the globe uncovering forgotten plant compounds, investigated the most overlooked environmental toxins, and now works with leading scientists and governments to bring these breakthroughs into functional medicine and human performance. Together, they break down: • How rare plant compounds like osmotin support adiponectin and mitochondrial repair • Why PFAS, synthetic fragrances, and EMFs are sabotaging your biology • How environmental toxins contribute to hormone disruption and infertility • What makes tap water so dangerous and how to fix it with simple filtration • Why microplastics and heavy metals are harder to avoid than ever • The role of habit design, detox protocols, and indoor air quality in biohacking longevity • Why removing toxins first leads to better results in fasting, ketosis, nootropics, and cold therapy This episode delivers practical tools for building resilience, improving detox capacity, and navigating the modern world with awareness. You’ll also get insights into the systems that have failed to protect public health and how personal action can create collective change. If you’re interested in senolytics, sleep optimization, neurohacking, and smarter ways to upgrade your environment, you’ll find those topics explored in depth throughout this channel. Whether you’re detoxing from hidden toxins or optimizing with Danger Coffee, this conversation aligns with the core principles of Smarter Not Harder and the mission of Upgrade Labs. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: -OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Darin’s Website – https://superlife.com/ • Darin’s Instagram: https://www.instagram.com/darinolien/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:10 Intro • 02:14 Meet Darin Olien • 04:26 Wildfires and Pollution • 07:13 PFAS and Everyday Toxins • 12:37 Corporate and Regulatory Failure • 26:36 Synthetic Fragrances • 36:12 Water and Air Filtration • 36:53 Indoor Air Quality • 38:33 Building Healthy Habits • 40:05 Essential Oils and Hormones • 41:54 Tofu, Tempeh, and Estrogen • 46:34 Adiponectin and Biohacking • 47:04 Osmotin for Longevity • 49:48 Stem Cells and Repair • 53:57 Communicating Science • 01:04:12 Nutrition and the Microbiome • 01:06:14 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Juni 1h 5min

The Anti-Aging Skincare Trends That Are DAMAGING Your Skin | Amitay Eshel  : 1292

The Anti-Aging Skincare Trends That Are DAMAGING Your Skin | Amitay Eshel : 1292

Your anti-aging skincare routine might be secretly aging you faster. In this episode, you’ll uncover how trending skincare products including vitamin C serums, harsh exfoliants, and blue light therapies can damage your skin’s mitochondria, accelerate senescence, and trigger systemic inflammation. You’ll learn how to reverse this damage, support cellular repair, and choose smarter formulations that work with your biology for long-term skin and brain health. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Amitay Eshel, a pioneer in biohacking skincare and founder of Young Goose. With expertise in regenerative aesthetics and advanced bioactive formulations, Amitay is leading the charge in applying longevity science, epigenetics, and senolytics to skincare. His work helps high performers integrate topical nootropics, mitochondrial support, and neurohacking principles directly into their daily routine through the skin. You’ll explore how skin aging connects to brain inflammation, how leaky skin barriers affect immune health, and why most anti-aging trends are outdated or biologically disruptive. The Human Upgrade unpacks how red-light therapy, ketosis, cold therapy, fasting, and self-quantification tools can be leveraged to enhance skin function from the inside out. This is a masterclass in smarter not harder skincare, rooted in cellular optimization and performance longevity. This episode is essential listening for anyone serious about biohacking, human performance, skincare longevity, mitochondria, Upgrade Labs-style recovery, and science-backed beauty routines. You’ll learn: • Which anti-aging skincare trends actually age you faster • How mitochondria and senescent cells influence visible aging and inflammation • What role neurohacking and the skin-brain connection play in longevity • How to repair the skin barrier and reduce oxidative stress naturally • The best red light, cold therapy, and fasting tools to reverse skin aging • How to use skin as a self-quantification tool for overall health • Why smarter skincare equals better cognitive and biological performance Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: -OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Young Goose Website – https://www.younggoose.com/ and use code “Dave10” at checkout to get a discount! • Young Goose Instagram: https://www.instagram.com/young_goose_skincare/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 00:52 – Intro • 01:27 – Anti-Aging Mistakes • 05:20 – Skin Recovery Science • 07:44 – NAD & Mitochondria • 08:52 – Autophagy Compounds • 12:06 – Sleep & Topicals • 18:36 – Overtraining Effects • 21:07 – Vitamin C & Antioxidants • 28:48 – Breakthrough Formulations • 35:50 – Tallow vs. MCT • 36:11 – Sun & Longevity • 37:28 – Red Light Therapy • 40:12 – UV Light Benefits • 42:18 – Advanced Skincare Tech • 48:48 – NAD Topicals • 01:00:05 – Building Your Routine • 01:07:39 – Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Juni 1h 8min

Why Most Supplements Are a WASTE of Money (And What Actually Works)  : 1291

Why Most Supplements Are a WASTE of Money (And What Actually Works) : 1291

Most supplements don’t work, and this episode reveals why. You’ll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jeff Boyd, founder of MTE and a leader in the new wave of performance supplements. With a background in data-driven wellness and a decade of experience optimizing human performance without caffeine or sugar, Jeff breaks down the science of nootropics, adaptogens, and smart nutrient stacking. His work focuses on self-quantification, nervous system regulation, and sustainable energy for founders, athletes, and high performers. Together, they explore why 85% of supplements are designed to fail, how to activate mitochondria for real results, and what it means to biohack your biology smarter, not harder. This isn’t just about supplements. It’s about reclaiming your energy, upgrading your brain, and aligning your stack with how your body actually works. You’ll also hear how fasting, sleep optimization, and even subtle neurohacking protocols support long-term resilience and better decision-making. You’ll Learn: • The real reason most supplements don’t absorb and how to fix it • How to build a caffeine-free stack that fuels energy, mood, and clarity • The latest in adaptogens, nootropics, and functional medicine • How to align your supplement timing with circadian biology and ketosis • Why “clean labels” often mean nothing • How emotional regulation and neurotransmitters shape performance • Tools for self-quantification and supplement personalization This is essential listening for anyone serious about biohacking, longevity, smarter supplementation, mitochondrial health, sleep optimization, emotional resilience, and conscious human performance. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks questions no one else dares and brings you real tools to become more resilient, aware, and high performing. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • MTE website – www.getmte.com • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:13 Saffron Benefits • 02:26 Medicinal Herbs • 04:12 Supplement Formulation • 13:16 Theanine & GABA • 20:06 Adaptogens & Performance • 23:23 Stress & Muscle Growth • 24:03 Parenting & Energy • 27:47 Nervous System for Kids • 35:15 Sleep for Families • 36:41 Wrap-Up & Offers See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Juni 43min

Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA  – Rick Doblin  : 1290

Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA – Rick Doblin : 1290

Psychedelic therapy is on the verge of reshaping mental health, trauma healing, and human consciousness. This episode reveals what’s really happening behind the scenes at the FDA, inside pharmaceutical companies, and within the global movement to legalize MDMA-assisted therapy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Rick Doblin, PhD, the legendary founder of MAPS and one of the most influential figures in psychedelic science. With nearly 40 years leading clinical research on MDMA, psilocybin, and trauma healing, Rick brings unmatched insight into how these compounds are transforming functional medicine, emotional resilience, and neuroplasticity. They break down the regulatory battle over MDMA therapy, the clash between pharmaceutical profit and public benefit, and the urgent need to combine pharmacology with therapy for real results. You’ll also learn how psychedelics impact neurohacking, epigenetics, and the default mode network—and why the next frontier of self-transformation may be couples therapy with MDMA. This episode offers critical knowledge for anyone serious about biohacking, trauma release, mental performance, and accessing deeper states of healing. This podcast channel dives into the intersections of psychedelics with fasting, ketosis, cold therapy, and self-quantification—and how altered states can unlock more energy, better relationships, and lasting change. You’ll Learn: • Why separating therapy from psychedelics is the most dangerous path forward • How MAPS evolved into a public benefit pharma company—and what went wrong • The real story behind the FDA’s rejection of MDMA therapy in 2024 • How MDMA affects neuroplasticity, mitochondria, and trauma recovery • Why group therapy and couples therapy are the future of psychedelic healing • The dangers of overusing ketamine—and how it’s being exploited by profit-driven clinics • What the Psychedelic Science 2025 conference will reveal about the future of medicine, spirituality, and consciousness hacking • How psychedelics could reverse epigenetic trauma passed down through generations • The role of default mode network suppression in spiritual experiences and trauma resolution • Why the war on drugs was never about safety—and what a post-drug-war world might look like Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, neurohacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off- ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Psychedelic Science Conference 2025 Website – https://www.psychedelicscience.org/ • Rick’s Website: https://maps.org/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 02:00 Intro • 03:43 Rise of Psychedelic Pharma • 05:00 Therapy vs. Profit • 06:44 Neurofeedback + Psychedelics • 08:28 Origins of Drug Laws • 14:06 MDMA Safety + Usage • 16:32 Psychedelics in Therapy + Meditation • 25:18 Psychedelic Hierarchy for New Users • 26:51 Psychedelic Churches + Culture • 28:58 Ayahuasca: Spiritual Insights • 30:24 MDMA and Federal Policy • 31:09 Inside the FDA Decision • 32:52 Therapeutic Promise of Psychedelics • 34:43 Psychedelics + Spirituality • 37:37 Neuroscience of Psychedelics • 40:12 Epigenetics + Generational Trauma • 43:50 War on Drugs Revisited • 46:37 Future of Legalization • 49:55 MDMA for Couples • 51:29 Group Therapy with Psychedelics • 52:26 Psychedelic Science 2025 Preview See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Juni 53min

Should You Eat Dirt? The “Healthy” Foods Destroying Your Gut – Dr. Josh Axe : 1289

Should You Eat Dirt? The “Healthy” Foods Destroying Your Gut – Dr. Josh Axe : 1289

You’ve been told to eat clean, but what if your “healthy” foods are wrecking your gut, crushing your hormones, and aging you faster? This episode exposes the nutrient-depleted truth behind modern diets, soil erosion, and why regenerative farming might be the key to reversing chronic disease, boosting mitochondria, and rebuilding your biology from the ground up. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Josh Axe, a trusted pioneer in functional medicine, bestselling author, and co-founder of Ancient Nutrition. Dr. Axe bridges the gap between biblical farming, ancestral nutrition, and modern science to explain how your food and even your supplements may be harming your human performance, digestion, and brain health. With clinical insights, personal stories, and science-backed tools, he shares what to eat instead if you want real longevity, energy, and healing. They dig into the collapse of soil nutrients, how monocropping damages the microbiome, and why organic food standards may be outdated. You’ll learn how regenerative agriculture rebuilds the earth and your gut, and why biohacking starts with dirt, not pills. Plus, they explore the hormonal chaos caused by seed oils, plastics, blue light, sleep disruption, and even birth control, especially in relation to testosterone loss in men and women. This episode also touches on biblical nutrition, fasting cycles, natural nootropics, testosterone-supporting peptides, the dangers of synthetic vitamins, and the future of real-time self-quantification. From poop-powered farming to smarter sourcing, it’s a wild ride into how food, faith, and farming affect every part of your biology. This is essential listening for anyone serious about biohacking, neurohacking, longevity, Upgrade Labs, Danger Coffee, Smarter Not Harder, and understanding the real root of disease and dysfunction. You’ll Learn: • Why regenerative farming beats “organic” for health and the planet • How depleted soil is linked to hormone imbalances and chronic disease • What birth control is doing to testosterone, fertility, and mitochondrial health • Why your supplements may just be “expensive pee” • The truth about biblical farming and why dirt still matters • How to support testosterone naturally with diet, peptides, and habits • Why sleep optimization, mineral balance, and circadian alignment are key for healing Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. - Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Josh Axe’s Website – https://thehealthinstitute.com/ • Josh Axe’s Instagram: https://www.instagram.com/drjoshaxe/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:52 Intro • 01:01 From Medicine to Farming • 02:21 Regenerative Farming • 03:36 Fixing Modern Agriculture • 05:43 Biblical Farming Meets Modern Science • 08:23 The Truth About Organic Food • 12:41 What’s Causing the Testosterone Crash • 18:07 Hormonal Birth Control • 27:37 New Hormone Replacement • 29:58 The Future of Health Tracking • 32:00 What Is Biblical Farming? • 33:38 Biblical Principles of Nutrition • 33:55 Foods Most Mentioned in the Bible • 35:17 Pork, Parasites, and Dietary Laws • 37:29 Chinese Medicine’s View on Pork • 39:36 Did the Flood Shorten Human Lifespan? • 42:26 Biodynamic Farming and Spirituality • 54:27 Fatherhood and Words That Heal • 56:21 What Josh Feeds His Kids • 01:03:41 Mental Health, Faith, and Healing • 01:05:36 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Juni 1h 5min

How 5G Affects Brainwaves (and the New Science to Fix It) : 1288

How 5G Affects Brainwaves (and the New Science to Fix It) : 1288

Your brain is under constant assault from devices you use every day. This episode reveals the hidden effects of 5G on brain function, cognitive performance, and nervous system stress, along with the science-backed method that neutralizes the damage. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Philipp Samor von Holtzendorff-Fehling, founder of Quantum Upgrade and a former VP at T-Mobile, to explore groundbreaking EEG research that shows how EMF exposure disrupts brainwaves in real time. Philipp shares how new tools are changing the way we approach biohacking, human performance, and energy medicine, and why even hardcore skeptics are paying attention. They break down double-blind studies, ATP production, and real-world EMF mitigation techniques that support brain health, mitochondrial resilience, and recovery. You’ll hear why professional athletes, clinicians, and even animals are benefiting from non-invasive approaches once dismissed as fringe, and how to evaluate what actually works in your own biology. This conversation is essential for anyone focused on biohacking, self-quantification, neurohacking, longevity, functional medicine, Upgrade Labs protocols, and protecting the brain in a wireless world. Whether you’re optimizing your nervous system, improving sleep, or just trying to stay sharp in a high-EMF environment, this episode gives you a toolset to reclaim your state. You’ll learn: • What EEG brain scans reveal after just 30 minutes of 5G exposure • Why ATP production increases in certain energetic fields • How energy fields influence brainwaves, stress, and performance • The connection between EMFs, mitochondrial function, and resilience • Why placebo doesn’t explain these results and what that means for self-tracking • How to use energetic tools alongside Danger Coffee, cold therapy, fasting, and nootropics Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. - Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Quantum Upgrade Website – Go to https://quantumupgrade.io/Dave for a free trial. • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Quantum Upgrade Instagram: https://www.instagram.com/quantumupgrade.io/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:54 Intro • 01:18 Resistance to Energy Work • 03:25 Inner Intuition • 04:22 Science vs Experience • 09:12 Quantum Effects on Body • 13:43 Biohacking for Pets • 15:43 EMFs & Quantum Upgrade • 23:39 Explaining Quantum Tech • 27:58 Understanding Frequencies • 28:53 Scientific Proof & Use • 31:07 Brain Support Tools • 32:28 Ethics & Consent • 34:09 EMF Defense & Biofield • 39:07 Meditation & Altered States • 46:59 Performance Optimization • 48:02 Science Catching Up • 50:39 Free Trial & How to Try See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Juni 52min

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